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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6TYL

Crystal structure of mammalian Ric-8A:Galpha(i):nanobody complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0001701biological_processin utero embryonic development
A0001944biological_processvasculature development
A0001965molecular_functionG-protein alpha-subunit binding
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0005096molecular_functionGTPase activator activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0006457biological_processprotein folding
A0007186biological_processG protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0007369biological_processgastrulation
A0008542biological_processvisual learning
A0009416biological_processresponse to light stimulus
A0016020cellular_componentmembrane
A0042074biological_processcell migration involved in gastrulation
A0044183molecular_functionprotein folding chaperone
A0070586biological_processcell-cell adhesion involved in gastrulation
A0071711biological_processbasement membrane organization
B0000166molecular_functionnucleotide binding
B0000287molecular_functionmagnesium ion binding
B0001664molecular_functionG protein-coupled receptor binding
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0005938cellular_componentcell cortex
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
B0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
B0007198biological_processadenylate cyclase-inhibiting serotonin receptor signaling pathway
B0010855molecular_functionadenylate cyclase inhibitor activity
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0019001molecular_functionguanyl nucleotide binding
B0019003molecular_functionGDP binding
B0030496cellular_componentmidbody
B0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0031749molecular_functionD2 dopamine receptor binding
B0031821molecular_functionG protein-coupled serotonin receptor binding
B0032794molecular_functionGTPase activating protein binding
B0032991cellular_componentprotein-containing complex
B0034695biological_processresponse to prostaglandin E
B0043303biological_processmast cell degranulation
B0045542biological_processpositive regulation of cholesterol biosynthetic process
B0046872molecular_functionmetal ion binding
B0050805biological_processnegative regulation of synaptic transmission
B0051301biological_processcell division
B0060236biological_processregulation of mitotic spindle organization
B0070098biological_processchemokine-mediated signaling pathway
B0072678biological_processT cell migration
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099645biological_processneurotransmitter receptor localization to postsynaptic specialization membrane
B1904322biological_processcellular response to forskolin
B1904778biological_processpositive regulation of protein localization to cell cortex
F0001701biological_processin utero embryonic development
F0001944biological_processvasculature development
F0001965molecular_functionG-protein alpha-subunit binding
F0005085molecular_functionguanyl-nucleotide exchange factor activity
F0005096molecular_functionGTPase activator activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005886cellular_componentplasma membrane
F0005938cellular_componentcell cortex
F0006457biological_processprotein folding
F0007186biological_processG protein-coupled receptor signaling pathway
F0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
F0007369biological_processgastrulation
F0008542biological_processvisual learning
F0009416biological_processresponse to light stimulus
F0016020cellular_componentmembrane
F0042074biological_processcell migration involved in gastrulation
F0044183molecular_functionprotein folding chaperone
F0070586biological_processcell-cell adhesion involved in gastrulation
F0071711biological_processbasement membrane organization
G0000166molecular_functionnucleotide binding
G0000287molecular_functionmagnesium ion binding
G0001664molecular_functionG protein-coupled receptor binding
G0003924molecular_functionGTPase activity
G0003925molecular_functionG protein activity
G0005515molecular_functionprotein binding
G0005525molecular_functionGTP binding
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005813cellular_componentcentrosome
G0005829cellular_componentcytosol
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0005938cellular_componentcell cortex
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
G0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
G0007198biological_processadenylate cyclase-inhibiting serotonin receptor signaling pathway
G0010855molecular_functionadenylate cyclase inhibitor activity
G0016020cellular_componentmembrane
G0016787molecular_functionhydrolase activity
G0019001molecular_functionguanyl nucleotide binding
G0019003molecular_functionGDP binding
G0030496cellular_componentmidbody
G0031683molecular_functionG-protein beta/gamma-subunit complex binding
G0031749molecular_functionD2 dopamine receptor binding
G0031821molecular_functionG protein-coupled serotonin receptor binding
G0032794molecular_functionGTPase activating protein binding
G0032991cellular_componentprotein-containing complex
G0034695biological_processresponse to prostaglandin E
G0043303biological_processmast cell degranulation
G0045542biological_processpositive regulation of cholesterol biosynthetic process
G0046872molecular_functionmetal ion binding
G0050805biological_processnegative regulation of synaptic transmission
G0051301biological_processcell division
G0060236biological_processregulation of mitotic spindle organization
G0070098biological_processchemokine-mediated signaling pathway
G0072678biological_processT cell migration
G0098794cellular_componentpostsynapse
G0098978cellular_componentglutamatergic synapse
G0099645biological_processneurotransmitter receptor localization to postsynaptic specialization membrane
G1904322biological_processcellular response to forskolin
G1904778biological_processpositive regulation of protein localization to cell cortex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by CK2","evidences":[{"source":"PubMed","id":"29844055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32103024","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32126208","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by CK2","evidences":[{"source":"PubMed","id":"29844055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32103024","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32126208","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q3TIR3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues26
DetailsRegion: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues18
DetailsRegion: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues14
DetailsRegion: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues10
DetailsRegion: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"PDB","id":"1AS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GIA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GIL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FFA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N0D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PAQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25037222","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9705312","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PAO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PDB","id":"1AS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GIA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GIL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FFA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N0D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PAQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idMCSA1
Number of Residues4
DetailsM-CSA 533
ChainResidueDetails
HLYS43electrostatic stabiliser
HVAL48electrostatic stabiliser
site_idMCSA2
Number of Residues4
DetailsM-CSA 533
ChainResidueDetails
ILYS43electrostatic stabiliser
IVAL48electrostatic stabiliser

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PDB entries from 2026-02-25

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