6TUO
Crystal structure of Archaeoglobus fulgidus Argonaute protein with cognate DNA oligoduplex 5'-pATTGTACGTACAAT
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 501 |
| Chain | Residue |
| A | GLN159 |
| A | LEU427 |
| R | DA1 |
| R | DT3 |
| R | HOH108 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 502 |
| Chain | Residue |
| A | LYS317 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue BME A 503 |
| Chain | Residue |
| A | GLY313 |
| A | LYS315 |
| A | ASP369 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue BME A 504 |
| Chain | Residue |
| A | GLY255 |
| A | LYS256 |
| A | ARG257 |
| A | PRO258 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue BME A 505 |
| Chain | Residue |
| A | VAL173 |
| A | ASP174 |
| A | LYS177 |
| A | LYS204 |
| A | GLU370 |
| A | TYR373 |
| A | HOH677 |
| A | HOH724 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 507 |
| Chain | Residue |
| A | SER214 |
| A | ILE216 |
| A | PRO411 |
| A | ILE412 |
| A | ASN413 |
| A | HOH622 |
| A | HOH693 |
| A | HOH730 |
| A | HOH750 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 508 |
| Chain | Residue |
| A | SER179 |
| A | LYS248 |
| A | LEU249 |
| A | THR250 |
| A | LYS286 |
| A | TYR287 |
| A | ALA288 |
| A | TRP355 |
| A | ASN363 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 509 |
| Chain | Residue |
| A | ASP353 |
| A | ASN354 |
| A | TRP355 |
| A | HOH741 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 510 |
| Chain | Residue |
| A | TYR46 |
| A | ILE104 |
| A | GLY107 |
| A | VAL108 |
| A | ILE134 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 129 |
| Details | Region: {"description":"Mid domain","evidences":[{"source":"PubMed","id":"19187762","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33633170","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Region: {"description":"Binds 5'-phosphorylated end of guide DNA","evidences":[{"source":"PubMed","id":"19187762","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W42","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Region: {"description":"Binds target DNA","evidences":[{"source":"PubMed","id":"19187762","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W42","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | Region: {"description":"Binds guide DNA","evidences":[{"source":"PubMed","id":"19187762","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W42","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"1YTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BGG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2W42","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
