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6TRW

Crystal structure of DPP8 in complex with the EIL peptide (SLRFLFEGQRIADNH)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004177molecular_functionaminopeptidase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006508biological_processproteolysis
A0006915biological_processapoptotic process
A0006955biological_processimmune response
A0008236molecular_functionserine-type peptidase activity
A0008239molecular_functiondipeptidyl-peptidase activity
A0043069biological_processnegative regulation of programmed cell death
B0004177molecular_functionaminopeptidase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006508biological_processproteolysis
B0006915biological_processapoptotic process
B0006955biological_processimmune response
B0008236molecular_functionserine-type peptidase activity
B0008239molecular_functiondipeptidyl-peptidase activity
B0043069biological_processnegative regulation of programmed cell death
C0004177molecular_functionaminopeptidase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006508biological_processproteolysis
C0006915biological_processapoptotic process
C0006955biological_processimmune response
C0008236molecular_functionserine-type peptidase activity
C0008239molecular_functiondipeptidyl-peptidase activity
C0043069biological_processnegative regulation of programmed cell death
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue NA A 901
ChainResidue
AARG158
AGLN274
AGLU275
AASP278
ATYR280

site_idAC2
Number of Residues5
Detailsbinding site for residue NA B 901
ChainResidue
BTYR280
BARG158
BGLN274
BGLU275
BASP278

site_idAC3
Number of Residues5
Detailsbinding site for residue NA C 901
ChainResidue
CARG158
CGLN274
CGLU275
CASP278
CTYR280

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues9
DetailsACT_SITE: Charge relay system => ECO:0000305|PubMed:12534281, ECO:0000305|PubMed:29382749
ChainResidueDetails
ASER755
AASP833
AHIS865
BSER755
BASP833
BHIS865
CSER755
CASP833
CHIS865

226707

PDB entries from 2024-10-30

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