6TQS
The crystal structure of the MSP domain of human MOSPD2 in complex with the conventional FFAT motif of ORP1.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 501 |
| Chain | Residue |
| A | PRO326 |
| A | VAL355 |
| A | HOH613 |
| A | HOH639 |
| A | HOH642 |
| D | SER331 |
| D | VAL351 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | HIS438 |
| A | ARG439 |
| A | HOH612 |
| D | SER340 |
| A | PHE323 |
| A | GLU437 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue TFA A 503 |
| Chain | Residue |
| A | PHE323 |
| A | GLY325 |
| A | PRO326 |
| A | LEU327 |
| A | LEU328 |
| A | ILE330 |
| A | ALA409 |
| A | MET436 |
| A | GLU437 |
| A | HOH612 |
| D | GLY339 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | THR418 |
| A | GLY419 |
| F | GLU345 |
| F | LYS346 |
| F | GLY395 |
| F | LEU397 |
| F | HOH609 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 505 |
| Chain | Residue |
| A | HIS394 |
| A | GLY395 |
| A | HOH643 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 506 |
| Chain | Residue |
| A | SER447 |
| F | ARG439 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residue TFA B 601 |
| Chain | Residue |
| B | PHE323 |
| B | GLY325 |
| B | PRO326 |
| B | LEU327 |
| B | LEU328 |
| B | ILE330 |
| B | ALA409 |
| B | MET436 |
| B | GLU437 |
| B | HOH705 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 602 |
| Chain | Residue |
| B | HIS438 |
| B | ARG439 |
| E | SER340 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 601 |
| Chain | Residue |
| C | GLU437 |
| C | HIS438 |
| C | ARG439 |
| F | SER340 |
| F | LYS346 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue TFA C 602 |
| Chain | Residue |
| C | PHE323 |
| C | GLY325 |
| C | PRO326 |
| C | LEU327 |
| C | LEU328 |
| C | ILE330 |
| C | ALA409 |
| C | MET436 |
| C | GLU437 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue PEG C 603 |
| Chain | Residue |
| C | LYS324 |
| F | TYR337 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 604 |
| Chain | Residue |
| C | ARG373 |
| C | HIS394 |
| C | GLY395 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue TFA D 601 |
| Chain | Residue |
| D | PHE323 |
| D | GLY325 |
| D | PRO326 |
| D | LEU327 |
| D | LEU328 |
| D | ILE330 |
| D | MET436 |
| D | GLU437 |
| site_id | AD5 |
| Number of Residues | 10 |
| Details | binding site for residue TFA E 501 |
| Chain | Residue |
| E | PHE323 |
| E | GLY325 |
| E | PRO326 |
| E | LEU327 |
| E | LEU328 |
| E | ILE330 |
| E | ALA409 |
| E | MET436 |
| E | GLU437 |
| E | HOH611 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 E 502 |
| Chain | Residue |
| C | SER340 |
| E | GLU437 |
| E | HIS438 |
| E | ARG439 |
| E | HOH630 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 E 503 |
| Chain | Residue |
| C | LYS318 |
| E | LYS324 |
| E | HIS329 |
| E | HOH615 |
| site_id | AD8 |
| Number of Residues | 10 |
| Details | binding site for residue TFA F 501 |
| Chain | Residue |
| F | LEU328 |
| F | ILE330 |
| F | ALA409 |
| F | MET436 |
| F | GLU437 |
| F | HOH604 |
| F | PHE323 |
| F | GLY325 |
| F | PRO326 |
| F | LEU327 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue 1PE F 502 |
| Chain | Residue |
| F | LYS363 |
| F | LYS363 |
| F | ARG365 |
| F | ARG365 |
| F | PRO369 |
| F | PRO369 |
| F | SER377 |
| F | SER377 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 F 503 |
| Chain | Residue |
| A | GLU342 |
| F | ARG365 |
| F | LYS428 |
| F | ARG432 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 708 |
| Details | Domain: {"description":"MSP","evidences":[{"source":"PubMed","id":"29858488","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Region: {"description":"Required for FFAT motif binding and phosphorylated FFAT motif binding","evidences":[{"source":"PubMed","id":"33124732","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6TQU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Site: {"description":"Required for phosphorylated FFAT motif binding","evidences":[{"source":"PubMed","id":"33124732","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TQU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Site: {"description":"Required for FFAT motif binding","evidences":[{"source":"PubMed","id":"33124732","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TQS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
