6TM5

Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Nek2A substrate at 3.9 angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005680	cellular_component	anaphase-promoting complex
A	0005829	cellular_component	cytosol
A	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
A	0007346	biological_process	regulation of mitotic cell cycle
A	0016567	biological_process	protein ubiquitination
A	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
A	0051301	biological_process	cell division
A	0051445	biological_process	regulation of meiotic cell cycle
A	0060090	molecular_function	molecular adaptor activity
A	0070936	biological_process	protein K48-linked ubiquitination
A	0070979	biological_process	protein K11-linked ubiquitination
A	0141198	biological_process	protein branched polyubiquitination
B	0000278	biological_process	mitotic cell cycle
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005680	cellular_component	anaphase-promoting complex
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0007346	biological_process	regulation of mitotic cell cycle
B	0008270	molecular_function	zinc ion binding
B	0016567	biological_process	protein ubiquitination
B	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
B	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
B	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
B	0046872	molecular_function	metal ion binding
B	0051301	biological_process	cell division
B	0051445	biological_process	regulation of meiotic cell cycle
B	0061630	molecular_function	ubiquitin protein ligase activity
B	0070936	biological_process	protein K48-linked ubiquitination
B	0070979	biological_process	protein K11-linked ubiquitination
B	0097602	molecular_function	cullin family protein binding
B	0141198	biological_process	protein branched polyubiquitination
C	0000278	biological_process	mitotic cell cycle
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005680	cellular_component	anaphase-promoting complex
C	0005829	cellular_component	cytosol
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0007080	biological_process	mitotic metaphase chromosome alignment
C	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
C	0007096	biological_process	regulation of exit from mitosis
C	0007346	biological_process	regulation of mitotic cell cycle
C	0016567	biological_process	protein ubiquitination
C	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
C	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
C	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
C	0051301	biological_process	cell division
C	0051445	biological_process	regulation of meiotic cell cycle
C	0070936	biological_process	protein K48-linked ubiquitination
C	0070979	biological_process	protein K11-linked ubiquitination
C	0141198	biological_process	protein branched polyubiquitination
D	0005515	molecular_function	protein binding
D	0005654	cellular_component	nucleoplasm
D	0005680	cellular_component	anaphase-promoting complex
D	0005829	cellular_component	cytosol
D	0007346	biological_process	regulation of mitotic cell cycle
D	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
D	0051301	biological_process	cell division
D	0051445	biological_process	regulation of meiotic cell cycle
D	0070936	biological_process	protein K48-linked ubiquitination
D	0070979	biological_process	protein K11-linked ubiquitination
D	0090266	biological_process	regulation of mitotic cell cycle spindle assembly checkpoint
D	0141198	biological_process	protein branched polyubiquitination
E	0000775	cellular_component	chromosome, centromeric region
E	0000776	cellular_component	kinetochore
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005680	cellular_component	anaphase-promoting complex
E	0005694	cellular_component	chromosome
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0007346	biological_process	regulation of mitotic cell cycle
E	0016567	biological_process	protein ubiquitination
E	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
E	0051301	biological_process	cell division
E	0051445	biological_process	regulation of meiotic cell cycle
E	0070936	biological_process	protein K48-linked ubiquitination
E	0070979	biological_process	protein K11-linked ubiquitination
E	0141198	biological_process	protein branched polyubiquitination
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005680	cellular_component	anaphase-promoting complex
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005819	cellular_component	spindle
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
F	0007346	biological_process	regulation of mitotic cell cycle
F	0016567	biological_process	protein ubiquitination
F	0019903	molecular_function	protein phosphatase binding
F	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
F	0051301	biological_process	cell division
F	0051445	biological_process	regulation of meiotic cell cycle
F	0070936	biological_process	protein K48-linked ubiquitination
F	0070979	biological_process	protein K11-linked ubiquitination
F	0072686	cellular_component	mitotic spindle
F	0141198	biological_process	protein branched polyubiquitination
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005680	cellular_component	anaphase-promoting complex
G	0005829	cellular_component	cytosol
G	0007346	biological_process	regulation of mitotic cell cycle
G	0016567	biological_process	protein ubiquitination
G	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
G	0051301	biological_process	cell division
G	0051445	biological_process	regulation of meiotic cell cycle
G	0070936	biological_process	protein K48-linked ubiquitination
G	0070979	biological_process	protein K11-linked ubiquitination
G	0141198	biological_process	protein branched polyubiquitination
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005680	cellular_component	anaphase-promoting complex
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005819	cellular_component	spindle
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
H	0007346	biological_process	regulation of mitotic cell cycle
H	0016567	biological_process	protein ubiquitination
H	0019903	molecular_function	protein phosphatase binding
H	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
H	0051301	biological_process	cell division
H	0051445	biological_process	regulation of meiotic cell cycle
H	0070936	biological_process	protein K48-linked ubiquitination
H	0070979	biological_process	protein K11-linked ubiquitination
H	0072686	cellular_component	mitotic spindle
H	0141198	biological_process	protein branched polyubiquitination
I	0004842	molecular_function	ubiquitin-protein transferase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005680	cellular_component	anaphase-promoting complex
I	0005829	cellular_component	cytosol
I	0007346	biological_process	regulation of mitotic cell cycle
I	0016567	biological_process	protein ubiquitination
I	0019903	molecular_function	protein phosphatase binding
I	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
I	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
I	0034399	cellular_component	nuclear periphery
I	0051301	biological_process	cell division
I	0051445	biological_process	regulation of meiotic cell cycle
I	0070936	biological_process	protein K48-linked ubiquitination
I	0070979	biological_process	protein K11-linked ubiquitination
I	0141198	biological_process	protein branched polyubiquitination
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005680	cellular_component	anaphase-promoting complex
J	0005737	cellular_component	cytoplasm
J	0005813	cellular_component	centrosome
J	0005819	cellular_component	spindle
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0007346	biological_process	regulation of mitotic cell cycle
J	0016567	biological_process	protein ubiquitination
J	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
J	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
J	0051301	biological_process	cell division
J	0051445	biological_process	regulation of meiotic cell cycle
J	0070936	biological_process	protein K48-linked ubiquitination
J	0070979	biological_process	protein K11-linked ubiquitination
J	0072686	cellular_component	mitotic spindle
J	0141198	biological_process	protein branched polyubiquitination
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005680	cellular_component	anaphase-promoting complex
K	0005737	cellular_component	cytoplasm
K	0005813	cellular_component	centrosome
K	0005819	cellular_component	spindle
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0007346	biological_process	regulation of mitotic cell cycle
K	0016567	biological_process	protein ubiquitination
K	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
K	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
K	0051301	biological_process	cell division
K	0051445	biological_process	regulation of meiotic cell cycle
K	0070936	biological_process	protein K48-linked ubiquitination
K	0070979	biological_process	protein K11-linked ubiquitination
K	0072686	cellular_component	mitotic spindle
K	0141198	biological_process	protein branched polyubiquitination
L	0005515	molecular_function	protein binding
L	0005654	cellular_component	nucleoplasm
L	0005680	cellular_component	anaphase-promoting complex
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0007346	biological_process	regulation of mitotic cell cycle
L	0016567	biological_process	protein ubiquitination
L	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
L	0051301	biological_process	cell division
L	0051445	biological_process	regulation of meiotic cell cycle
L	0070936	biological_process	protein K48-linked ubiquitination
L	0070979	biological_process	protein K11-linked ubiquitination
L	0141198	biological_process	protein branched polyubiquitination
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005680	cellular_component	anaphase-promoting complex
M	0007346	biological_process	regulation of mitotic cell cycle
M	0016567	biological_process	protein ubiquitination
M	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
M	0051301	biological_process	cell division
M	0051445	biological_process	regulation of meiotic cell cycle
M	0070936	biological_process	protein K48-linked ubiquitination
M	0070979	biological_process	protein K11-linked ubiquitination
M	0141198	biological_process	protein branched polyubiquitination
N	0005515	molecular_function	protein binding
N	0005654	cellular_component	nucleoplasm
N	0005680	cellular_component	anaphase-promoting complex
N	0005829	cellular_component	cytosol
N	0006511	biological_process	ubiquitin-dependent protein catabolic process
N	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
N	0007346	biological_process	regulation of mitotic cell cycle
N	0007399	biological_process	nervous system development
N	0010629	biological_process	negative regulation of gene expression
N	0016567	biological_process	protein ubiquitination
N	0030154	biological_process	cell differentiation
N	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
N	0031461	cellular_component	cullin-RING ubiquitin ligase complex
N	0031625	molecular_function	ubiquitin protein ligase binding
N	0031915	biological_process	positive regulation of synaptic plasticity
N	0045773	biological_process	positive regulation of axon extension
N	0050775	biological_process	positive regulation of dendrite morphogenesis
N	0051301	biological_process	cell division
N	0051445	biological_process	regulation of meiotic cell cycle
N	0070936	biological_process	protein K48-linked ubiquitination
N	0070979	biological_process	protein K11-linked ubiquitination
N	0090129	biological_process	positive regulation of synapse maturation
N	0141198	biological_process	protein branched polyubiquitination
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005680	cellular_component	anaphase-promoting complex
O	0005737	cellular_component	cytoplasm
O	0005819	cellular_component	spindle
O	0005829	cellular_component	cytosol
O	0005856	cellular_component	cytoskeleton
O	0007346	biological_process	regulation of mitotic cell cycle
O	0016567	biological_process	protein ubiquitination
O	0019903	molecular_function	protein phosphatase binding
O	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
O	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
O	0051301	biological_process	cell division
O	0051445	biological_process	regulation of meiotic cell cycle
O	0070936	biological_process	protein K48-linked ubiquitination
O	0070979	biological_process	protein K11-linked ubiquitination
O	0141198	biological_process	protein branched polyubiquitination
P	0000278	biological_process	mitotic cell cycle
P	0004842	molecular_function	ubiquitin-protein transferase activity
P	0005515	molecular_function	protein binding
P	0005654	cellular_component	nucleoplasm
P	0005680	cellular_component	anaphase-promoting complex
P	0005829	cellular_component	cytosol
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0007080	biological_process	mitotic metaphase chromosome alignment
P	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
P	0007096	biological_process	regulation of exit from mitosis
P	0007346	biological_process	regulation of mitotic cell cycle
P	0016567	biological_process	protein ubiquitination
P	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
P	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
P	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
P	0051301	biological_process	cell division
P	0051445	biological_process	regulation of meiotic cell cycle
P	0070936	biological_process	protein K48-linked ubiquitination
P	0070979	biological_process	protein K11-linked ubiquitination
P	0141198	biological_process	protein branched polyubiquitination
Q	0000070	biological_process	mitotic sister chromatid segregation
Q	0000278	biological_process	mitotic cell cycle
Q	0000775	cellular_component	chromosome, centromeric region
Q	0000776	cellular_component	kinetochore
Q	0000794	cellular_component	condensed nuclear chromosome
Q	0000922	cellular_component	spindle pole
Q	0001824	biological_process	blastocyst development
Q	0004672	molecular_function	protein kinase activity
Q	0004674	molecular_function	protein serine/threonine kinase activity
Q	0005515	molecular_function	protein binding
Q	0005524	molecular_function	ATP binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005694	cellular_component	chromosome
Q	0005730	cellular_component	nucleolus
Q	0005737	cellular_component	cytoplasm
Q	0005813	cellular_component	centrosome
Q	0005829	cellular_component	cytosol
Q	0005856	cellular_component	cytoskeleton
Q	0005874	cellular_component	microtubule
Q	0006338	biological_process	chromatin remodeling
Q	0006468	biological_process	protein phosphorylation
Q	0007059	biological_process	chromosome segregation
Q	0007088	biological_process	regulation of mitotic nuclear division
Q	0016310	biological_process	phosphorylation
Q	0019903	molecular_function	protein phosphatase binding
Q	0030496	cellular_component	midbody
Q	0032206	biological_process	positive regulation of telomere maintenance
Q	0032991	cellular_component	protein-containing complex
Q	0044024	molecular_function	histone H2AS1 kinase activity
Q	0046602	biological_process	regulation of mitotic centrosome separation
Q	0046777	biological_process	protein autophosphorylation
Q	0046872	molecular_function	metal ion binding
Q	0051225	biological_process	spindle assembly
Q	0051299	biological_process	centrosome separation
Q	0051301	biological_process	cell division
Q	0051321	biological_process	meiotic cell cycle
Q	0051988	biological_process	regulation of attachment of spindle microtubules to kinetochore
Q	0090307	biological_process	mitotic spindle assembly
Q	0106310	molecular_function	protein serine kinase activity
Q	1903126	biological_process	negative regulation of centriole-centriole cohesion
S	0000070	biological_process	mitotic sister chromatid segregation
S	0000278	biological_process	mitotic cell cycle
S	0000775	cellular_component	chromosome, centromeric region
S	0000776	cellular_component	kinetochore
S	0000794	cellular_component	condensed nuclear chromosome
S	0000922	cellular_component	spindle pole
S	0001824	biological_process	blastocyst development
S	0004672	molecular_function	protein kinase activity
S	0004674	molecular_function	protein serine/threonine kinase activity
S	0005515	molecular_function	protein binding
S	0005524	molecular_function	ATP binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005694	cellular_component	chromosome
S	0005730	cellular_component	nucleolus
S	0005737	cellular_component	cytoplasm
S	0005813	cellular_component	centrosome
S	0005829	cellular_component	cytosol
S	0005856	cellular_component	cytoskeleton
S	0005874	cellular_component	microtubule
S	0006338	biological_process	chromatin remodeling
S	0006468	biological_process	protein phosphorylation
S	0007059	biological_process	chromosome segregation
S	0007088	biological_process	regulation of mitotic nuclear division
S	0016310	biological_process	phosphorylation
S	0019903	molecular_function	protein phosphatase binding
S	0030496	cellular_component	midbody
S	0032206	biological_process	positive regulation of telomere maintenance
S	0032991	cellular_component	protein-containing complex
S	0044024	molecular_function	histone H2AS1 kinase activity
S	0046602	biological_process	regulation of mitotic centrosome separation
S	0046777	biological_process	protein autophosphorylation
S	0046872	molecular_function	metal ion binding
S	0051225	biological_process	spindle assembly
S	0051299	biological_process	centrosome separation
S	0051301	biological_process	cell division
S	0051321	biological_process	meiotic cell cycle
S	0051988	biological_process	regulation of attachment of spindle microtubules to kinetochore
S	0090307	biological_process	mitotic spindle assembly
S	0106310	molecular_function	protein serine kinase activity
S	1903126	biological_process	negative regulation of centriole-centriole cohesion
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005680	cellular_component	anaphase-promoting complex
W	0005829	cellular_component	cytosol
W	0007346	biological_process	regulation of mitotic cell cycle
W	0016567	biological_process	protein ubiquitination
W	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
W	0051301	biological_process	cell division
W	0051445	biological_process	regulation of meiotic cell cycle
W	0070936	biological_process	protein K48-linked ubiquitination
W	0070979	biological_process	protein K11-linked ubiquitination
W	0141198	biological_process	protein branched polyubiquitination
X	0000792	cellular_component	heterochromatin
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005680	cellular_component	anaphase-promoting complex
X	0005737	cellular_component	cytoplasm
X	0005819	cellular_component	spindle
X	0005829	cellular_component	cytosol
X	0005856	cellular_component	cytoskeleton
X	0007346	biological_process	regulation of mitotic cell cycle
X	0007420	biological_process	brain development
X	0015630	cellular_component	microtubule cytoskeleton
X	0016567	biological_process	protein ubiquitination
X	0019903	molecular_function	protein phosphatase binding
X	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
X	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
X	0051301	biological_process	cell division
X	0051445	biological_process	regulation of meiotic cell cycle
X	0070936	biological_process	protein K48-linked ubiquitination
X	0070979	biological_process	protein K11-linked ubiquitination
X	0140767	molecular_function	enzyme-substrate adaptor activity
X	0141198	biological_process	protein branched polyubiquitination
Y	0000792	cellular_component	heterochromatin
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005680	cellular_component	anaphase-promoting complex
Y	0005737	cellular_component	cytoplasm
Y	0005819	cellular_component	spindle
Y	0005829	cellular_component	cytosol
Y	0005856	cellular_component	cytoskeleton
Y	0007346	biological_process	regulation of mitotic cell cycle
Y	0007420	biological_process	brain development
Y	0015630	cellular_component	microtubule cytoskeleton
Y	0016567	biological_process	protein ubiquitination
Y	0019903	molecular_function	protein phosphatase binding
Y	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
Y	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
Y	0051301	biological_process	cell division
Y	0051445	biological_process	regulation of meiotic cell cycle
Y	0070936	biological_process	protein K48-linked ubiquitination
Y	0070979	biological_process	protein K11-linked ubiquitination
Y	0140767	molecular_function	enzyme-substrate adaptor activity
Y	0141198	biological_process	protein branched polyubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue ZN B 101

Chain	Residue
B	CYS23
B	MET28
B	HIS56

---

site_id	AC2
Number of Residues	3
Details	binding site for residue ZN B 102

Chain	Residue
B	CYS51
B	HIS53
B	CYS76

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN B 103

Chain	Residue
B	CYS44
B	CYS33
B	CYS34
B	CYS37

---

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpaNVFL

Chain	Residue	Details
S	VAL191-LEU203
Q	VAL191-LEU203

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
Q	ASP195
Y	LYS263
J	SER595
K	SER112
K	SER490
K	SER595

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
Q	ILE68
B	CYS59
B	CYS73
B	CYS76
K	SER560
F	THR313
F	THR430
H	THR209
H	THR244
H	THR313
H	THR430
B	HIS58

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
Q	LYS91
K	THR581
H	SER291
H	SER435

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000305|PubMed:17197699

Chain	Residue	Details
Q	THR224
K	THR599
H	SER339
H	SER438

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000305|PubMed:17197699, ECO:0007744|PubMed:23186163

Chain	Residue	Details
Q	SER225
H	THR366
I	LYS798

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:17197699

Chain	Residue	Details
Q	THR229
Q	THR233

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
Q	SER238
Q	SER354

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:17197699

Chain	Residue	Details
Q	SER295
H	SER426

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195

Chain	Residue	Details
Q	SER350
H	SER821

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphoserine; by STK3/MST2 => ECO:0000269|PubMed:17197699, ECO:0000269|PubMed:21076410

Chain	Residue	Details
Q	SER410
P	THR596

---

site_id	SWS_FT_FI11
Number of Residues	3
Details	MOD_RES: Phosphoserine; by STK3/MST2 => ECO:0000269|PubMed:21076410

Chain	Residue	Details
Q	SER419
Q	SER460
Q	SER492

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:17197699

Chain	Residue	Details
Q	SER441
Q	SER444
Q	SER456
Q	SER482

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:17197699, ECO:0007744|PubMed:18088087

Chain	Residue	Details
Q	SER451

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	SER686

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:14657031, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER688

---