6TM3

Structure of methylene-tetrahydromethanopterin dehydrogenase from Methylorubrum extorquens AM1 in a close conformation containing NADP+ and methylene-H4MPT

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004488	molecular_function	methylenetetrahydrofolate dehydrogenase (NADP+) activity
A	0005737	cellular_component	cytoplasm
A	0006730	biological_process	one-carbon metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0046294	biological_process	formaldehyde catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	35
Details	binding site for residue NAP A 401

Chain	Residue
A	ASN97
A	LYS156
A	ALA196
A	GLY197
A	ALA198
A	ILE199
A	LEU201
A	TYR221
A	ALA249
A	GLY253
A	LYS256
A	THR102
A	H4M403
A	HOH531
A	HOH559
A	HOH579
A	HOH590
A	HOH596
A	HOH599
A	HOH601
A	HOH632
A	HOH645
A	ALA127
A	HOH665
A	HOH690
A	HOH704
A	HOH732
A	HOH755
A	HOH802
A	THR129
A	GLY130
A	PRO131
A	VAL132
A	GLY151
A	ARG152

---

site_id	AC2
Number of Residues	13
Details	binding site for residue GOL A 402

Chain	Residue
A	GLN158
A	ASP162
A	ASN165
A	VAL172
A	EDO415
A	HOH510
A	HOH522
A	HOH535
A	HOH614
A	HOH643
A	HOH767
A	HOH809
A	HOH838

---

site_id	AC3
Number of Residues	19
Details	binding site for residue H4M A 403

Chain	Residue
A	SER16
A	PHE18
A	ASP19
A	TYR51
A	THR52
A	ARG53
A	GLY54
A	ASN97
A	GLY98
A	LEU250
A	GLY253
A	LYS256
A	LEU257
A	NAP401
A	EDO404
A	HOH505
A	HOH577
A	HOH668
A	HOH977

---

site_id	AC4
Number of Residues	8
Details	binding site for residue EDO A 404

Chain	Residue
A	SER16
A	H4M403
A	HOH583
A	HOH603
A	HOH850
A	HOH934
A	HOH970
A	HOH977

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 405

Chain	Residue
A	LEU139
A	GLU278
A	HOH501
A	HOH582
A	HOH604

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 406

Chain	Residue
A	GLY68
A	HOH560
A	HOH579
A	HOH600
A	HOH719

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO A 407

Chain	Residue
A	GLU279
A	LYS282
A	LEU283
A	EDO417
A	HOH594
A	HOH649
A	HOH718

---

site_id	AC8
Number of Residues	4
Details	binding site for residue EDO A 408

Chain	Residue
A	GLY242
A	GLY243
A	LYS244
A	HOH520

---

site_id	AC9
Number of Residues	6
Details	binding site for residue EDO A 410

Chain	Residue
A	HOH578
A	HOH653
A	HOH862
A	PHE85
A	LYS166
A	PRO225

---

site_id	AD1
Number of Residues	8
Details	binding site for residue EDO A 411

Chain	Residue
A	PRO39
A	ASP40
A	LYS82
A	EDO416
A	HOH533
A	HOH543
A	HOH672
A	HOH745

---

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO A 412

Chain	Residue
A	LYS3
A	ASP29
A	HIS30
A	HOH606
A	HOH689

---

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO A 413

Chain	Residue
A	ARG152
A	HOH710
A	HOH754
A	HOH812

---

site_id	AD4
Number of Residues	3
Details	binding site for residue EDO A 414

Chain	Residue
A	ARG83
A	GLN224
A	HOH680

---

site_id	AD5
Number of Residues	10
Details	binding site for residue EDO A 415

Chain	Residue
A	PHE85
A	PHE88
A	ALA223
A	LEU227
A	ALA234
A	LEU250
A	GOL402
A	HOH510
A	HOH522
A	HOH911

---

site_id	AD6
Number of Residues	7
Details	binding site for residue EDO A 416

Chain	Residue
A	PRO39
A	ASP40
A	LYS82
A	EDO411
A	HOH533
A	HOH543
A	HOH745

---

site_id	AD7
Number of Residues	8
Details	binding site for residue EDO A 417

Chain	Residue
A	GLY273
A	VAL274
A	PHE275
A	GLU279
A	EDO407
A	HOH504
A	HOH516
A	HOH674

---

site_id	AD8
Number of Residues	4
Details	binding site for residue LI A 418

Chain	Residue
A	ASP155
A	GLN158
A	HOH610
A	HOH788

---

site_id	AD9
Number of Residues	5
Details	binding site for residue LI A 419

Chain	Residue
A	ASP180
A	ARG183
A	LEU203
A	PRO205
A	HOH639

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11297742","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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