Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046294 | biological_process | formaldehyde catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 35 |
| Details | binding site for residue NAP A 401 |
| Chain | Residue |
| A | ASN97 |
| A | LYS156 |
| A | ALA196 |
| A | GLY197 |
| A | ALA198 |
| A | ILE199 |
| A | LEU201 |
| A | TYR221 |
| A | ALA249 |
| A | GLY253 |
| A | LYS256 |
| A | THR102 |
| A | H4M403 |
| A | HOH531 |
| A | HOH559 |
| A | HOH579 |
| A | HOH590 |
| A | HOH596 |
| A | HOH599 |
| A | HOH601 |
| A | HOH632 |
| A | HOH645 |
| A | ALA127 |
| A | HOH665 |
| A | HOH690 |
| A | HOH704 |
| A | HOH732 |
| A | HOH755 |
| A | HOH802 |
| A | THR129 |
| A | GLY130 |
| A | PRO131 |
| A | VAL132 |
| A | GLY151 |
| A | ARG152 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | GLN158 |
| A | ASP162 |
| A | ASN165 |
| A | VAL172 |
| A | EDO415 |
| A | HOH510 |
| A | HOH522 |
| A | HOH535 |
| A | HOH614 |
| A | HOH643 |
| A | HOH767 |
| A | HOH809 |
| A | HOH838 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | binding site for residue H4M A 403 |
| Chain | Residue |
| A | SER16 |
| A | PHE18 |
| A | ASP19 |
| A | TYR51 |
| A | THR52 |
| A | ARG53 |
| A | GLY54 |
| A | ASN97 |
| A | GLY98 |
| A | LEU250 |
| A | GLY253 |
| A | LYS256 |
| A | LEU257 |
| A | NAP401 |
| A | EDO404 |
| A | HOH505 |
| A | HOH577 |
| A | HOH668 |
| A | HOH977 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | SER16 |
| A | H4M403 |
| A | HOH583 |
| A | HOH603 |
| A | HOH850 |
| A | HOH934 |
| A | HOH970 |
| A | HOH977 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | LEU139 |
| A | GLU278 |
| A | HOH501 |
| A | HOH582 |
| A | HOH604 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | GLY68 |
| A | HOH560 |
| A | HOH579 |
| A | HOH600 |
| A | HOH719 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 407 |
| Chain | Residue |
| A | GLU279 |
| A | LYS282 |
| A | LEU283 |
| A | EDO417 |
| A | HOH594 |
| A | HOH649 |
| A | HOH718 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 408 |
| Chain | Residue |
| A | GLY242 |
| A | GLY243 |
| A | LYS244 |
| A | HOH520 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 410 |
| Chain | Residue |
| A | HOH578 |
| A | HOH653 |
| A | HOH862 |
| A | PHE85 |
| A | LYS166 |
| A | PRO225 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 411 |
| Chain | Residue |
| A | PRO39 |
| A | ASP40 |
| A | LYS82 |
| A | EDO416 |
| A | HOH533 |
| A | HOH543 |
| A | HOH672 |
| A | HOH745 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 412 |
| Chain | Residue |
| A | LYS3 |
| A | ASP29 |
| A | HIS30 |
| A | HOH606 |
| A | HOH689 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 413 |
| Chain | Residue |
| A | ARG152 |
| A | HOH710 |
| A | HOH754 |
| A | HOH812 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 414 |
| Chain | Residue |
| A | ARG83 |
| A | GLN224 |
| A | HOH680 |
| site_id | AD5 |
| Number of Residues | 10 |
| Details | binding site for residue EDO A 415 |
| Chain | Residue |
| A | PHE85 |
| A | PHE88 |
| A | ALA223 |
| A | LEU227 |
| A | ALA234 |
| A | LEU250 |
| A | GOL402 |
| A | HOH510 |
| A | HOH522 |
| A | HOH911 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 416 |
| Chain | Residue |
| A | PRO39 |
| A | ASP40 |
| A | LYS82 |
| A | EDO411 |
| A | HOH533 |
| A | HOH543 |
| A | HOH745 |
| site_id | AD7 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 417 |
| Chain | Residue |
| A | GLY273 |
| A | VAL274 |
| A | PHE275 |
| A | GLU279 |
| A | EDO407 |
| A | HOH504 |
| A | HOH516 |
| A | HOH674 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue LI A 418 |
| Chain | Residue |
| A | ASP155 |
| A | GLN158 |
| A | HOH610 |
| A | HOH788 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue LI A 419 |
| Chain | Residue |
| A | ASP180 |
| A | ARG183 |
| A | LEU203 |
| A | PRO205 |
| A | HOH639 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | THR129 | |
| A | ARG152 | |
| A | THR195 | |
| A | LYS256 | |
