6TKO
Phosphorylated turkey beta1 adrenoceptor with bound agonist formoterol coupled to arrestin-2 in lipid nanodisc.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004935 | molecular_function | adrenergic receptor activity |
| A | 0004940 | molecular_function | beta1-adrenergic receptor activity |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| A | 0016020 | cellular_component | membrane |
| A | 0045823 | biological_process | positive regulation of heart contraction |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0000785 | cellular_component | chromatin |
| B | 0001664 | molecular_function | G protein-coupled receptor binding |
| B | 0001934 | biological_process | positive regulation of protein phosphorylation |
| B | 0002029 | biological_process | desensitization of G protein-coupled receptor signaling pathway |
| B | 0002031 | biological_process | G protein-coupled receptor internalization |
| B | 0002092 | biological_process | positive regulation of receptor internalization |
| B | 0003713 | molecular_function | transcription coactivator activity |
| B | 0004402 | molecular_function | histone acetyltransferase activity |
| B | 0004857 | molecular_function | enzyme inhibitor activity |
| B | 0005096 | molecular_function | GTPase activator activity |
| B | 0005159 | molecular_function | insulin-like growth factor receptor binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005905 | cellular_component | clathrin-coated pit |
| B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| B | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| B | 0007165 | biological_process | signal transduction |
| B | 0007600 | biological_process | sensory perception |
| B | 0009968 | biological_process | negative regulation of signal transduction |
| B | 0010613 | biological_process | positive regulation of cardiac muscle hypertrophy |
| B | 0015031 | biological_process | protein transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0016604 | cellular_component | nuclear body |
| B | 0019899 | molecular_function | enzyme binding |
| B | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| B | 0030666 | cellular_component | endocytic vesicle membrane |
| B | 0031143 | cellular_component | pseudopodium |
| B | 0031397 | biological_process | negative regulation of protein ubiquitination |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0031625 | molecular_function | ubiquitin protein ligase binding |
| B | 0031701 | molecular_function | angiotensin receptor binding |
| B | 0032088 | biological_process | negative regulation of NF-kappaB transcription factor activity |
| B | 0032715 | biological_process | negative regulation of interleukin-6 production |
| B | 0032717 | biological_process | negative regulation of interleukin-8 production |
| B | 0035025 | biological_process | positive regulation of Rho protein signal transduction |
| B | 0042995 | cellular_component | cell projection |
| B | 0043149 | biological_process | stress fiber assembly |
| B | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| B | 0045746 | biological_process | negative regulation of Notch signaling pathway |
| B | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| B | 0060090 | molecular_function | molecular adaptor activity |
| B | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
| B | 1902533 | biological_process | positive regulation of intracellular signal transduction |
| B | 1990763 | molecular_function | arrestin family protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue H98 A 2001 |
| Chain | Residue |
| A | ASP121 |
| A | PHE325 |
| A | VAL326 |
| A | ASN329 |
| A | TYR333 |
| A | VAL125 |
| A | ASP200 |
| A | PHE201 |
| A | SER211 |
| A | SER215 |
| A | PHE306 |
| A | PHE307 |
| A | ASN310 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide GLU A 1356 and SEP A 1357 |
| Chain | Residue |
| A | ALA1358 |
| A | TPO1359 |
| B | LYS11 |
| B | PRO14 |
| B | ARG165 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide SEP A 1357 and ALA A 1358 |
| Chain | Residue |
| A | GLU1356 |
| A | TPO1359 |
| A | TPO1360 |
| B | LYS11 |
| B | ALA12 |
| B | ARG165 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide ALA A 1358 and TPO A 1359 |
| Chain | Residue |
| A | GLU1356 |
| A | SEP1357 |
| A | TPO1360 |
| A | ALA1361 |
| B | LYS11 |
| B | ALA12 |
| B | LYS294 |
| B | HIS295 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residues TPO A 1359 and TPO A 1360 |
| Chain | Residue |
| A | SEP1357 |
| A | ALA1358 |
| A | ALA1361 |
| B | LYS11 |
| B | ARG25 |
| B | LEU166 |
| B | LYS294 |
| B | HIS295 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide TPO A 1360 and ALA A 1361 |
| Chain | Residue |
| A | ALA1358 |
| A | TPO1359 |
| A | SEP1362 |
| B | PHE9 |
| B | LYS10 |
| B | LYS11 |
| B | ARG25 |
| B | LEU166 |
| B | LYS294 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide ALA A 1361 and SEP A 1362 |
| Chain | Residue |
| A | TPO1359 |
| A | TPO1360 |
| A | SEP1363 |
| B | ARG7 |
| B | VAL8 |
| B | PHE9 |
| B | LYS10 |
| L | SER31 |
| L | ARG67 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residues SEP A 1362 and SEP A 1363 |
| Chain | Residue |
| A | ALA1361 |
| A | SEP1364 |
| A | LEU1365 |
| B | ARG7 |
| B | VAL8 |
| B | LYS10 |
| B | LYS107 |
| L | SER31 |
| L | ARG67 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residues SEP A 1363 and SEP A 1364 |
| Chain | Residue |
| A | SEP1362 |
| A | LEU1365 |
| B | ARG7 |
| B | VAL8 |
| B | LYS10 |
| B | LYS107 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for Di-peptide SEP A 1364 and LEU A 1365 |
| Chain | Residue |
| A | SEP1363 |
| A | ALA1366 |
| A | LYS1367 |
| B | THR6 |
| B | ARG7 |
| B | ARG103 |
| B | LYS107 |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIwTLCVIAIDRYLaI |
| Chain | Residue | Details |
| A | ALA127-ILE143 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| L | TYR193-HIS199 | |
| H | TYR204-HIS210 |
| site_id | PS00295 |
| Number of Residues | 19 |
| Details | ARRESTINS Arrestins signature. FRYGrEDcDVLGLtFrKDL |
| Chain | Residue | Details |
| B | PHE61-LEU79 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| B | LYS250 | |
| B | MET255 | |
| B | LYS324 | |
| B | LYS326 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q8BWG8 |
| Chain | Residue | Details |
| B | TYR47 | |
| A | ASP138-ARG155 | |
| A | ARG232-ASN313 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by GRK5 => ECO:0000269|PubMed:19661922, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | SER412 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 40 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:18594507 |
| Chain | Residue | Details |
| A | ARG104-GLU115 | |
| A | HIS180-ARG205 | |
| A | CYS344-ASP348 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=3 |
| Chain | Residue | Details |
| A | LEU116-ILE137 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=4 |
| Chain | Residue | Details |
| A | ALA156-MET179 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=5 |
| Chain | Residue | Details |
| A | ALA206-TYR231 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=6 |
| Chain | Residue | Details |
| A | VAL314-TYR343 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=7 |
| Chain | Residue | Details |
| A | PHE349-ASP1355 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 |
| Chain | Residue | Details |
| A | ASP121 | |
| A | SER211 | |
| A | LEU357 |
