6TGH

SHMT from Streptococcus thermophilus Tyr55Thr variant in complex with D-Serine both as external aldimine and as non-covalent complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004372	molecular_function	glycine hydroxymethyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006544	biological_process	glycine metabolic process
A	0006545	biological_process	glycine biosynthetic process
A	0006563	biological_process	L-serine metabolic process
A	0006730	biological_process	one-carbon metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0016740	molecular_function	transferase activity
A	0019264	biological_process	glycine biosynthetic process from serine
A	0030170	molecular_function	pyridoxal phosphate binding
A	0035999	biological_process	tetrahydrofolate interconversion
A	0046653	biological_process	tetrahydrofolate metabolic process
B	0004372	molecular_function	glycine hydroxymethyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006544	biological_process	glycine metabolic process
B	0006545	biological_process	glycine biosynthetic process
B	0006563	biological_process	L-serine metabolic process
B	0006730	biological_process	one-carbon metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0016740	molecular_function	transferase activity
B	0019264	biological_process	glycine biosynthetic process from serine
B	0030170	molecular_function	pyridoxal phosphate binding
B	0035999	biological_process	tetrahydrofolate interconversion
B	0046653	biological_process	tetrahydrofolate metabolic process
C	0004372	molecular_function	glycine hydroxymethyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006544	biological_process	glycine metabolic process
C	0006545	biological_process	glycine biosynthetic process
C	0006563	biological_process	L-serine metabolic process
C	0006730	biological_process	one-carbon metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0016740	molecular_function	transferase activity
C	0019264	biological_process	glycine biosynthetic process from serine
C	0030170	molecular_function	pyridoxal phosphate binding
C	0035999	biological_process	tetrahydrofolate interconversion
C	0046653	biological_process	tetrahydrofolate metabolic process
D	0004372	molecular_function	glycine hydroxymethyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006544	biological_process	glycine metabolic process
D	0006545	biological_process	glycine biosynthetic process
D	0006563	biological_process	L-serine metabolic process
D	0006730	biological_process	one-carbon metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0016740	molecular_function	transferase activity
D	0019264	biological_process	glycine biosynthetic process from serine
D	0030170	molecular_function	pyridoxal phosphate binding
D	0035999	biological_process	tetrahydrofolate interconversion
D	0046653	biological_process	tetrahydrofolate metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue NA A 501

Chain	Residue
A	ALA203
A	ALA206
A	HIS229
A	LYS230
A	THR231
A	LEU232

---

site_id	AC2
Number of Residues	19
Details	binding site for residue EVM A 502

Chain	Residue
A	SER99
A	HIS126
A	SER176
A	ASP201
A	ALA203
A	HIS204
A	THR227
A	HIS229
A	LYS230
A	ARG363
A	HOH601
A	HOH639
C	GLU57
C	TYR65
C	GLY261
C	GLY262
A	SER35
A	SER97
A	GLY98

---

site_id	AC3
Number of Residues	6
Details	binding site for residue NA C 501

Chain	Residue
C	ALA203
C	ALA206
C	HIS229
C	LYS230
C	THR231
C	LEU232

---

site_id	AC4
Number of Residues	8
Details	binding site for residue DSN C 502

Chain	Residue
A	GLU57
A	TYR65
C	SER35
C	HIS126
C	HIS204
C	ARG363
C	PLP503
C	HOH684

---

site_id	AC5
Number of Residues	7
Details	binding site for residue NA B 501

Chain	Residue
B	ALA203
B	ALA206
B	THR227
B	HIS229
B	LYS230
B	THR231
B	LEU232

---

site_id	AC6
Number of Residues	20
Details	binding site for residue EVM B 502

Chain	Residue
B	SER35
B	SER97
B	GLY98
B	SER99
B	HIS126
B	SER176
B	ASP201
B	ALA203
B	HIS204
B	THR227
B	HIS229
B	LYS230
B	ARG363
B	HOH602
D	THR55
D	TYR65
D	GLY261
D	GLY262
D	HOH613
D	HOH620

---

site_id	AC7
Number of Residues	9
Details	binding site for residue DSN D 501

Chain	Residue
B	GLU57
B	TYR65
D	SER35
D	HIS126
D	HIS204
D	LYS230
D	ARG363
D	PLP502
D	HOH619

---

site_id	AC8
Number of Residues	20
Details	binding site for Di-peptide PLP C 503 and LYS C 230

Chain	Residue
A	GLY261
A	GLY262
C	SER35
C	ASN37
C	SER97
C	GLY98
C	SER99
C	HIS126
C	HIS129
C	ASP201
C	ALA203
C	HIS204
C	THR227
C	HIS229
C	THR231
C	LEU232
C	ARG233
C	NA501
C	DSN502
C	HOH632

---

site_id	AC9
Number of Residues	20
Details	binding site for Di-peptide PLP D 502 and LYS D 230

Chain	Residue
D	SER97
D	GLY98
D	SER99
D	HIS126
D	HIS129
D	SER176
D	ASP201
D	ALA203
D	HIS204
D	THR227
D	HIS229
D	THR231
D	LEU232
D	ARG233
D	DSN501
D	HOH619
B	GLY261
B	GLY262
D	SER35
D	ASN37

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Functional Information from PROSITE/UniProt

site_id	PS00096
Number of Residues	17
Details	SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. HVtTTTTHKTLrGPRGG

Chain	Residue	Details
A	HIS222-GLY238

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