6TGH
SHMT from Streptococcus thermophilus Tyr55Thr variant in complex with D-Serine both as external aldimine and as non-covalent complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006544 | biological_process | glycine metabolic process |
| A | 0006545 | biological_process | glycine biosynthetic process |
| A | 0006563 | biological_process | L-serine metabolic process |
| A | 0019264 | biological_process | obsolete glycine biosynthetic process from L-serine |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| A | 0046653 | biological_process | tetrahydrofolate metabolic process |
| B | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006544 | biological_process | glycine metabolic process |
| B | 0006545 | biological_process | glycine biosynthetic process |
| B | 0006563 | biological_process | L-serine metabolic process |
| B | 0019264 | biological_process | obsolete glycine biosynthetic process from L-serine |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0035999 | biological_process | tetrahydrofolate interconversion |
| B | 0046653 | biological_process | tetrahydrofolate metabolic process |
| C | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006544 | biological_process | glycine metabolic process |
| C | 0006545 | biological_process | glycine biosynthetic process |
| C | 0006563 | biological_process | L-serine metabolic process |
| C | 0019264 | biological_process | obsolete glycine biosynthetic process from L-serine |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0035999 | biological_process | tetrahydrofolate interconversion |
| C | 0046653 | biological_process | tetrahydrofolate metabolic process |
| D | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006544 | biological_process | glycine metabolic process |
| D | 0006545 | biological_process | glycine biosynthetic process |
| D | 0006563 | biological_process | L-serine metabolic process |
| D | 0019264 | biological_process | obsolete glycine biosynthetic process from L-serine |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0035999 | biological_process | tetrahydrofolate interconversion |
| D | 0046653 | biological_process | tetrahydrofolate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 501 |
| Chain | Residue |
| A | ALA203 |
| A | ALA206 |
| A | HIS229 |
| A | LYS230 |
| A | THR231 |
| A | LEU232 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | binding site for residue EVM A 502 |
| Chain | Residue |
| A | SER99 |
| A | HIS126 |
| A | SER176 |
| A | ASP201 |
| A | ALA203 |
| A | HIS204 |
| A | THR227 |
| A | HIS229 |
| A | LYS230 |
| A | ARG363 |
| A | HOH601 |
| A | HOH639 |
| C | GLU57 |
| C | TYR65 |
| C | GLY261 |
| C | GLY262 |
| A | SER35 |
| A | SER97 |
| A | GLY98 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 501 |
| Chain | Residue |
| C | ALA203 |
| C | ALA206 |
| C | HIS229 |
| C | LYS230 |
| C | THR231 |
| C | LEU232 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue DSN C 502 |
| Chain | Residue |
| A | GLU57 |
| A | TYR65 |
| C | SER35 |
| C | HIS126 |
| C | HIS204 |
| C | ARG363 |
| C | PLP503 |
| C | HOH684 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue NA B 501 |
| Chain | Residue |
| B | ALA203 |
| B | ALA206 |
| B | THR227 |
| B | HIS229 |
| B | LYS230 |
| B | THR231 |
| B | LEU232 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | binding site for residue EVM B 502 |
| Chain | Residue |
| B | SER35 |
| B | SER97 |
| B | GLY98 |
| B | SER99 |
| B | HIS126 |
| B | SER176 |
| B | ASP201 |
| B | ALA203 |
| B | HIS204 |
| B | THR227 |
| B | HIS229 |
| B | LYS230 |
| B | ARG363 |
| B | HOH602 |
| D | THR55 |
| D | TYR65 |
| D | GLY261 |
| D | GLY262 |
| D | HOH613 |
| D | HOH620 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue DSN D 501 |
| Chain | Residue |
| B | GLU57 |
| B | TYR65 |
| D | SER35 |
| D | HIS126 |
| D | HIS204 |
| D | LYS230 |
| D | ARG363 |
| D | PLP502 |
| D | HOH619 |
| site_id | AC8 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide PLP C 503 and LYS C 230 |
| Chain | Residue |
| A | GLY261 |
| A | GLY262 |
| C | SER35 |
| C | ASN37 |
| C | SER97 |
| C | GLY98 |
| C | SER99 |
| C | HIS126 |
| C | HIS129 |
| C | ASP201 |
| C | ALA203 |
| C | HIS204 |
| C | THR227 |
| C | HIS229 |
| C | THR231 |
| C | LEU232 |
| C | ARG233 |
| C | NA501 |
| C | DSN502 |
| C | HOH632 |
| site_id | AC9 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide PLP D 502 and LYS D 230 |
| Chain | Residue |
| D | SER97 |
| D | GLY98 |
| D | SER99 |
| D | HIS126 |
| D | HIS129 |
| D | SER176 |
| D | ASP201 |
| D | ALA203 |
| D | HIS204 |
| D | THR227 |
| D | HIS229 |
| D | THR231 |
| D | LEU232 |
| D | ARG233 |
| D | DSN501 |
| D | HOH619 |
| B | GLY261 |
| B | GLY262 |
| D | SER35 |
| D | ASN37 |
Functional Information from PROSITE/UniProt
| site_id | PS00096 |
| Number of Residues | 17 |
| Details | SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. HVtTTTTHKTLrGPRGG |
| Chain | Residue | Details |
| A | HIS222-GLY238 |
