6TEO

Crystal structure of a yeast Snu114-Prp8 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
A	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
A	0000387	biological_process	spliceosomal snRNP assembly
A	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005681	cellular_component	spliceosomal complex
A	0005682	cellular_component	U5 snRNP
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006397	biological_process	mRNA processing
A	0008380	biological_process	RNA splicing
A	0030623	molecular_function	U5 snRNA binding
A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
A	0071007	cellular_component	U2-type catalytic step 2 spliceosome
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0005681	cellular_component	spliceosomal complex
C	0000244	biological_process	spliceosomal tri-snRNP complex assembly
C	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
C	0000387	biological_process	spliceosomal snRNP assembly
C	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005681	cellular_component	spliceosomal complex
C	0005682	cellular_component	U5 snRNP
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006397	biological_process	mRNA processing
C	0008380	biological_process	RNA splicing
C	0030623	molecular_function	U5 snRNA binding
C	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
C	0071007	cellular_component	U2-type catalytic step 2 spliceosome
D	0000398	biological_process	mRNA splicing, via spliceosome
D	0005681	cellular_component	spliceosomal complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 A 1101

Chain	Residue
A	GLN251
A	LYS254
A	HIS934

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site_id	AC2
Number of Residues	20
Details	binding site for residue GTP A 1102

Chain	Residue
A	THR147
A	SER148
A	LEU189
A	SER190
A	PRO216
A	GLY217
A	ASN268
A	LYS269
A	ASP271
A	SER315
A	THR316
A	LYS317
A	MG1103
A	HOH1201
A	PRO141
A	LEU142
A	HIS143
A	SER144
A	GLY145
A	LYS146

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MG A 1103

Chain	Residue
A	THR147
A	ASP179
A	LEU189
A	SER190
A	GTP1102
A	HOH1201

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 C 1101

Chain	Residue
C	GLN251
C	LYS254
C	ARG725
C	HIS934

---

site_id	AC5
Number of Residues	19
Details	binding site for residue GTP C 1102

Chain	Residue
C	PRO141
C	LEU142
C	HIS143
C	SER144
C	GLY145
C	LYS146
C	THR147
C	SER148
C	LEU189
C	SER190
C	GLY217
C	ASN268
C	LYS269
C	ASP271
C	SER315
C	THR316
C	LYS317
C	MG1103
C	HOH1202

---

site_id	AC6
Number of Residues	4
Details	binding site for residue MG C 1103

Chain	Residue
C	THR147
C	SER190
C	GTP1102
C	HOH1202

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLY140
A	ASP214
A	ASN268
C	GLY140
C	ASP214
C	ASN268

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	SER85
C	SER85

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	THR88
C	THR88

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