6T8Z

NAD+-dependent fungal formate dehydrogenase from Chaetomium thermophilum: A ternary complex with the oxidised form of the cofactor NAD+ and the substrate formate both at a primary and secondary sites.

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0005737	cellular_component	cytoplasm
AAA	0005829	cellular_component	cytosol
AAA	0008863	molecular_function	formate dehydrogenase (NAD+) activity
AAA	0016491	molecular_function	oxidoreductase activity
AAA	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
AAA	0042183	biological_process	formate catabolic process
AAA	0051287	molecular_function	NAD binding
BBB	0005737	cellular_component	cytoplasm
BBB	0005829	cellular_component	cytosol
BBB	0008863	molecular_function	formate dehydrogenase (NAD+) activity
BBB	0016491	molecular_function	oxidoreductase activity
BBB	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
BBB	0042183	biological_process	formate catabolic process
BBB	0051287	molecular_function	NAD binding
CCC	0005737	cellular_component	cytoplasm
CCC	0005829	cellular_component	cytosol
CCC	0008863	molecular_function	formate dehydrogenase (NAD+) activity
CCC	0016491	molecular_function	oxidoreductase activity
CCC	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
CCC	0042183	biological_process	formate catabolic process
CCC	0051287	molecular_function	NAD binding
DDD	0005737	cellular_component	cytoplasm
DDD	0005829	cellular_component	cytosol
DDD	0008863	molecular_function	formate dehydrogenase (NAD+) activity
DDD	0016491	molecular_function	oxidoreductase activity
DDD	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
DDD	0042183	biological_process	formate catabolic process
DDD	0051287	molecular_function	NAD binding

Functional Information from PROSITE/UniProt

site_id	PS00065
Number of Residues	29
Details	D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. VGTVGvGRIGervlrrlkgfdckeLLyYD

Chain	Residue	Details
AAA	VAL168-ASP196

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site_id	PS00670
Number of Residues	23
Details	D_2_HYDROXYACID_DH_2 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. MLaqCDVVtINcPlhesTrgLfN

Chain	Residue	Details
AAA	MET219-ASN241

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site_id	PS00671
Number of Residues	17
Details	D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MKrGsWLVNtARGaIVV

Chain	Residue	Details
AAA	MET248-VAL264

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03210

Chain	Residue	Details
AAA	ILE94
BBB	ASN120
BBB	ARG175
BBB	ASP196
BBB	PRO231
BBB	THR257
BBB	ASP283
BBB	HIS312
CCC	ILE94
CCC	ASN120
CCC	ARG175
AAA	ASN120
CCC	ASP196
CCC	PRO231
CCC	THR257
CCC	ASP283
CCC	HIS312
DDD	ILE94
DDD	ASN120
DDD	ARG175
DDD	ASP196
DDD	PRO231
AAA	ARG175
DDD	THR257
DDD	ASP283
DDD	HIS312
AAA	ASP196
AAA	PRO231
AAA	THR257
AAA	ASP283
AAA	HIS312
BBB	ILE94

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site_id	SWS_FT_FI2
Number of Residues	8
Details	SITE: Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_03210

Chain	Residue	Details
AAA	ARG259
AAA	HIS312
BBB	ARG259
BBB	HIS312
CCC	ARG259
CCC	HIS312
DDD	ARG259
DDD	HIS312

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