6T6F

Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 8 (CS275)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue MMW A 401

Chain	Residue
A	LEU29
A	ASN149
A	LEU151
A	SER164
A	ASP165
A	VAL37
A	ALA50
A	VAL82
A	GLN99
A	LEU100
A	VAL101
A	SER102
A	GLU148

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site_id	AC2
Number of Residues	12
Details	binding site for residue MMW B 401

Chain	Residue
B	LEU29
B	VAL37
B	ALA50
B	GLN99
B	LEU100
B	VAL101
B	SER102
B	GLU148
B	ASN149
B	LEU151
B	SER164
B	ASP165

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	29
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGAFSEVVlAeekatgklfavkc.....IPKK

Chain	Residue	Details
A	LEU29-LYS57

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKpeNLLY

Chain	Residue	Details
A	ILE140-TYR152

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP144
B	ASP144

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU29
A	LYS52
B	LEU29
B	LYS52

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	SER122
B	SER122

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by CaMKK1 and CaMKK2 => ECO:0000269|PubMed:12935886, ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	THR180
B	THR180

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site_id	SWS_FT_FI5
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447

Chain	Residue	Details
A	LYS113
B	LYS113

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