6T5T

Crystal structure of Archaeoglobus fulgidus Argonaute protein with cognate DNA oligoduplex 5'-pATTGTGGCCACAAT

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MG A 501

Chain	Residue
A	GLN159
A	LEU427
R	DA1
R	DT3
R	HOH107

---

site_id	AC2
Number of Residues	7
Details	binding site for residue MG A 502

Chain	Residue
A	HOH796
A	HOH803
A	HOH859
A	SER220
A	GLU221
A	LEU223
A	THR224

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MG A 503

Chain	Residue
A	SER59
A	GLU358
A	GLU359
A	TYR361
A	HIS362
A	HOH723

---

site_id	AC4
Number of Residues	2
Details	binding site for residue CL A 504

Chain	Residue
A	TRP299
A	LYS317

---

site_id	AC5
Number of Residues	6
Details	binding site for residue K A 505

Chain	Residue
A	SER43
A	SER43
A	LEU44
A	LEU44
A	HOH729
A	HOH729

---

site_id	AC6
Number of Residues	5
Details	binding site for residue K A 506

Chain	Residue
A	THR106
A	GLY107
A	HOH699
A	HOH854
A	HOH870

---

site_id	AC7
Number of Residues	5
Details	binding site for residue K A 507

Chain	Residue
A	LEU318
A	TYR323
A	SER347
A	HOH707
A	HOH727

---

site_id	AC8
Number of Residues	6
Details	binding site for residue BME A 508

Chain	Residue
A	GLY206
A	THR207
A	MET208
A	MET377
A	TRP379
A	TYR393

---

site_id	AC9
Number of Residues	6
Details	binding site for residue BME A 509

Chain	Residue
A	ILE213
A	SER214
A	ILE401
A	PRO411
A	ILE412
A	HOH771

---

site_id	AD1
Number of Residues	6
Details	binding site for residue BME A 510

Chain	Residue
A	ILE216
A	VAL217
A	TYR225
A	HOH606
A	HOH664
A	HOH885

---

site_id	AD2
Number of Residues	1
Details	binding site for residue BME A 511

Chain	Residue
A	PHE298

---

site_id	AD3
Number of Residues	3
Details	binding site for residue BME A 512

Chain	Residue
A	GLY313
A	ASP369
A	TYR372

---

site_id	AD4
Number of Residues	6
Details	binding site for residue BME A 513

Chain	Residue
A	LYS177
A	LYS204
A	GLU370
A	TYR373
A	HOH724
A	HOH807

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	129
Details	Region: {"description":"Mid domain","evidences":[{"source":"PubMed","id":"19187762","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33633170","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Region: {"description":"Binds 5'-phosphorylated end of guide DNA","evidences":[{"source":"PubMed","id":"19187762","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W42","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Region: {"description":"Binds target DNA","evidences":[{"source":"PubMed","id":"19187762","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W42","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Region: {"description":"Binds guide DNA","evidences":[{"source":"PubMed","id":"19187762","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W42","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"1YTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BGG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2W42","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---