6T0O

Crystal structure of YTHDC1 with fragment 14 (ACA_DC1_004)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
B	0003723	molecular_function	RNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue M6N A 601

Chain	Residue
A	LYS361
A	LEU439
A	HOH705
A	HOH729
A	SER362
A	ASN363
A	ASN367
A	TRP377
A	SER378
A	THR379
A	TRP428
A	PRO431

---

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 602

Chain	Residue
A	GLY344
A	SER346
A	LYS347
A	HOH708
A	HOH710

---

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 603

Chain	Residue
A	ASN363
A	PRO431
A	ALA432
A	HOH706
B	HIS505

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 604

Chain	Residue
A	SER417
A	GLU418
A	HIS420
A	HOH734

---

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 A 605

Chain	Residue
A	SER419
A	HIS420
A	HIS421
A	HOH701
A	HOH744

---

site_id	AC6
Number of Residues	1
Details	binding site for residue SO4 A 606

Chain	Residue
A	HOH742

---

site_id	AC7
Number of Residues	8
Details	binding site for residue SO4 A 607

Chain	Residue
A	GLN478
A	GLU479
A	HOH712
A	HOH728
A	HOH735
A	HOH758
A	HOH818
B	LYS347

---

site_id	AC8
Number of Residues	8
Details	binding site for residue M6N B 601

Chain	Residue
B	SER362
B	ASN363
B	ASN367
B	TRP377
B	SER378
B	THR379
B	TRP428
B	LEU439

---

site_id	AC9
Number of Residues	7
Details	binding site for residue SO4 B 602

Chain	Residue
B	ARG451
B	GLU452
B	HOH712
B	HOH720
B	HOH756
B	HOH757
B	HOH787

---

site_id	AD1
Number of Residues	5
Details	binding site for residue SO4 B 603

Chain	Residue
B	SER419
B	HIS420
B	HIS421
B	ARG451
B	HOH741

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	137
Details	Domain: {"description":"YTH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00225","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31670957","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25242552","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31670957","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25242552","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---