6SZW

Asymmetric complex of Factor XII and kininogen with gC1qR/C1QBP/P32 is governed by allostery

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005759	cellular_component	mitochondrial matrix
B	0005759	cellular_component	mitochondrial matrix
C	0005759	cellular_component	mitochondrial matrix

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue ZN A 301

Chain	Residue
A	ASP185
A	HIS187

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN B 301

Chain	Residue
B	ASP185
B	HIS187
B	HOH401
B	HOH402

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN C 301

Chain	Residue
C	HOH404
C	ASP185
C	HIS187
C	HOH402

---

Functional Information from PROSITE/UniProt

site_id	PS00023
Number of Residues	42
Details	FN2_1 Fibronectin type-II collagen-binding domain signature. ChfPFqYhrqlyhkCthkgrpgpqpWCattpNFdqdqrWgYC

Chain	Residue	Details
D	CYS28-CYS69

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	51
Details	Region: {"description":"C1q binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"17693683","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	45
Details	Region: {"description":"Interaction with MAVS","evidences":[{"source":"PubMed","id":"19164550","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---