6SXF
Crystal Structure of the Voltage-Gated Sodium Channel NavMs (F208L) in complex with Tamoxifen (2.8 Angstrom resolution)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001518 | cellular_component | voltage-gated sodium channel complex |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005248 | molecular_function | voltage-gated sodium channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| B | 0001518 | cellular_component | voltage-gated sodium channel complex |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005248 | molecular_function | voltage-gated sodium channel activity |
| B | 0005261 | molecular_function | monoatomic cation channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098655 | biological_process | monoatomic cation transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 301 |
| Chain | Residue |
| A | NA302 |
| A | NA302 |
| A | NA302 |
| A | NA302 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 302 |
| Chain | Residue |
| A | NA301 |
| A | NA301 |
| A | NA301 |
| A | NA301 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 303 |
| Chain | Residue |
| A | HOH407 |
| A | HOH407 |
| A | HOH407 |
| A | HOH407 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue 2CV A 304 |
| Chain | Residue |
| A | GLU159 |
| A | SER165 |
| A | LYS166 |
| A | TYR169 |
| A | THR170 |
| A | ARG186 |
| A | PRO193 |
| A | ASN194 |
| A | TRP196 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue 12P A 305 |
| Chain | Residue |
| A | PHE102 |
| A | MET148 |
| A | TYR153 |
| A | HIS192 |
| A | PRO193 |
| A | ASN194 |
| A | ALA195 |
| A | PHE198 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue 2CV A 306 |
| Chain | Residue |
| A | MET204 |
| A | THR207 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue CTX A 307 |
| Chain | Residue |
| A | ASP220 |
| A | ILE224 |
| A | THR225 |
| A | LYS226 |
| A | GLU227 |
| A | GLU229 |
| A | PRO240 |
| A | SER242 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue NA B 301 |
| Chain | Residue |
| B | NA302 |
| B | NA302 |
| B | NA302 |
| B | NA302 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue NA B 302 |
| Chain | Residue |
| B | NA301 |
| B | NA301 |
| B | NA301 |
| B | NA301 |
| B | NA303 |
| B | NA303 |
| B | NA303 |
| B | NA303 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue NA B 303 |
| Chain | Residue |
| B | NA302 |
| B | NA302 |
| B | NA302 |
| B | NA302 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue 2CV B 304 |
| Chain | Residue |
| B | SER165 |
| B | LEU168 |
| B | ASN194 |
| B | TRP196 |
| B | HOH405 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue 12P B 305 |
| Chain | Residue |
| B | PHE102 |
| B | TYR153 |
| B | HIS192 |
| B | PRO193 |
| B | ASN194 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue 2CV B 306 |
| Chain | Residue |
| B | MET175 |
| B | MET204 |
| site_id | AD5 |
| Number of Residues | 10 |
| Details | binding site for residue CTX B 307 |
| Chain | Residue |
| B | PRO129 |
| B | GLY130 |
| B | ASP220 |
| B | ALA223 |
| B | ILE224 |
| B | LYS226 |
| B | GLU227 |
| B | PRO240 |
| B | SER242 |
| B | CTX308 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue CTX B 308 |
| Chain | Residue |
| B | GLY130 |
| B | VAL131 |
| B | ASP220 |
| B | MET222 |
| B | LYS226 |
| B | LEU245 |
| B | CTX307 |
