6SSH

Structure of the TSC2 GAP domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005096	molecular_function	GTPase activator activity
A	0005634	cellular_component	nucleus
A	0043547	biological_process	positive regulation of GTPase activity
A	0051056	biological_process	regulation of small GTPase mediated signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue EDO A 301

Chain	Residue
A	GLY64
A	GLN65
A	TYR66
A	GLN84
A	EDO304
A	HOH414

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site_id	AC2
Number of Residues	6
Details	binding site for residue EDO A 302

Chain	Residue
A	HOH427
A	HOH434
A	HOH461
A	MET62
A	MET97
A	EDO305

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site_id	AC3
Number of Residues	6
Details	binding site for residue EDO A 303

Chain	Residue
A	GLN17
A	THR18
A	SER114
A	PHE118
A	ARG119
A	THR122

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site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 304

Chain	Residue
A	TYR68
A	GLN84
A	EDO301
A	HOH411

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site_id	AC5
Number of Residues	4
Details	binding site for residue EDO A 305

Chain	Residue
A	MET62
A	HIS91
A	EDO302
A	HOH434

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site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 306

Chain	Residue
A	GLY16
A	THR18
A	GLU22
A	HOH404
A	HOH489

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