6SN1
Crystal structure of the human INTS13-INTS14 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0007052 | biological_process | mitotic spindle organization |
| A | 0007346 | biological_process | regulation of mitotic cell cycle |
| A | 0016180 | biological_process | snRNA processing |
| A | 0016604 | cellular_component | nuclear body |
| A | 0030317 | biological_process | flagellated sperm motility |
| A | 0032039 | cellular_component | integrator complex |
| A | 0034243 | biological_process | regulation of transcription elongation by RNA polymerase II |
| A | 0051301 | biological_process | cell division |
| A | 0051642 | biological_process | centrosome localization |
| A | 0080154 | biological_process | regulation of fertilization |
| A | 0090435 | biological_process | protein localization to nuclear envelope |
| A | 0140297 | molecular_function | DNA-binding transcription factor binding |
| A | 0160232 | cellular_component | INTAC complex |
| A | 0160240 | biological_process | RNA polymerase II transcription initiation surveillance |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0016180 | biological_process | snRNA processing |
| B | 0032039 | cellular_component | integrator complex |
| B | 0034243 | biological_process | regulation of transcription elongation by RNA polymerase II |
| B | 0034472 | biological_process | snRNA 3'-end processing |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0160232 | cellular_component | INTAC complex |
| B | 0160240 | biological_process | RNA polymerase II transcription initiation surveillance |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 801 |
| Chain | Residue |
| A | HIS86 |
| A | HOH903 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 802 |
| Chain | Residue |
| A | HIS184 |
| A | LYS188 |
| B | LYS487 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 803 |
| Chain | Residue |
| A | TYR210 |
| A | VAL237 |
| A | ARG238 |
| A | HIS242 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 804 |
| Chain | Residue |
| A | TYR330 |
| B | ARG270 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 601 |
| Chain | Residue |
| A | PHE72 |
| B | PRO393 |
| B | LYS394 |
| B | ASN395 |
| B | ARG397 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 602 |
| Chain | Residue |
| B | ASN402 |
| B | ARG439 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 202 |
| Details | Domain: {"description":"VWFA"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38823386","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38906142","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8PK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EOC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38823386","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9EOC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
