6RVY
Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in absence of substrate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001618 | molecular_function | virus receptor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006865 | biological_process | amino acid transport |
| A | 0006868 | biological_process | glutamine transport |
| A | 0009925 | cellular_component | basal plasma membrane |
| A | 0010585 | biological_process | glutamine secretion |
| A | 0015171 | molecular_function | amino acid transmembrane transporter activity |
| A | 0015175 | molecular_function | neutral L-amino acid transmembrane transporter activity |
| A | 0015179 | molecular_function | L-amino acid transmembrane transporter activity |
| A | 0015183 | molecular_function | L-aspartate transmembrane transporter activity |
| A | 0015186 | molecular_function | L-glutamine transmembrane transporter activity |
| A | 0015194 | molecular_function | L-serine transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015804 | biological_process | neutral amino acid transport |
| A | 0015825 | biological_process | L-serine transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022834 | molecular_function | ligand-gated channel activity |
| A | 0030218 | biological_process | erythrocyte differentiation |
| A | 0038023 | molecular_function | signaling receptor activity |
| A | 0042470 | cellular_component | melanosome |
| A | 0046718 | biological_process | symbiont entry into host cell |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070207 | biological_process | protein homotrimerization |
| A | 0140009 | biological_process | L-aspartate import across plasma membrane |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| A | 1903803 | biological_process | L-glutamine import across plasma membrane |
| B | 0001618 | molecular_function | virus receptor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006865 | biological_process | amino acid transport |
| B | 0006868 | biological_process | glutamine transport |
| B | 0009925 | cellular_component | basal plasma membrane |
| B | 0010585 | biological_process | glutamine secretion |
| B | 0015171 | molecular_function | amino acid transmembrane transporter activity |
| B | 0015175 | molecular_function | neutral L-amino acid transmembrane transporter activity |
| B | 0015179 | molecular_function | L-amino acid transmembrane transporter activity |
| B | 0015183 | molecular_function | L-aspartate transmembrane transporter activity |
| B | 0015186 | molecular_function | L-glutamine transmembrane transporter activity |
| B | 0015194 | molecular_function | L-serine transmembrane transporter activity |
| B | 0015293 | molecular_function | symporter activity |
| B | 0015297 | molecular_function | antiporter activity |
| B | 0015804 | biological_process | neutral amino acid transport |
| B | 0015825 | biological_process | L-serine transport |
| B | 0016020 | cellular_component | membrane |
| B | 0022834 | molecular_function | ligand-gated channel activity |
| B | 0030218 | biological_process | erythrocyte differentiation |
| B | 0038023 | molecular_function | signaling receptor activity |
| B | 0042470 | cellular_component | melanosome |
| B | 0046718 | biological_process | symbiont entry into host cell |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070207 | biological_process | protein homotrimerization |
| B | 0140009 | biological_process | L-aspartate import across plasma membrane |
| B | 0150104 | biological_process | transport across blood-brain barrier |
| B | 1903803 | biological_process | L-glutamine import across plasma membrane |
| C | 0001618 | molecular_function | virus receptor activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006865 | biological_process | amino acid transport |
| C | 0006868 | biological_process | glutamine transport |
| C | 0009925 | cellular_component | basal plasma membrane |
| C | 0010585 | biological_process | glutamine secretion |
| C | 0015171 | molecular_function | amino acid transmembrane transporter activity |
| C | 0015175 | molecular_function | neutral L-amino acid transmembrane transporter activity |
| C | 0015179 | molecular_function | L-amino acid transmembrane transporter activity |
| C | 0015183 | molecular_function | L-aspartate transmembrane transporter activity |
| C | 0015186 | molecular_function | L-glutamine transmembrane transporter activity |
| C | 0015194 | molecular_function | L-serine transmembrane transporter activity |
| C | 0015293 | molecular_function | symporter activity |
| C | 0015297 | molecular_function | antiporter activity |
| C | 0015804 | biological_process | neutral amino acid transport |
| C | 0015825 | biological_process | L-serine transport |
| C | 0016020 | cellular_component | membrane |
| C | 0022834 | molecular_function | ligand-gated channel activity |
| C | 0030218 | biological_process | erythrocyte differentiation |
| C | 0038023 | molecular_function | signaling receptor activity |
| C | 0042470 | cellular_component | melanosome |
| C | 0046718 | biological_process | symbiont entry into host cell |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0070207 | biological_process | protein homotrimerization |
| C | 0140009 | biological_process | L-aspartate import across plasma membrane |
| C | 0150104 | biological_process | transport across blood-brain barrier |
| C | 1903803 | biological_process | L-glutamine import across plasma membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00713 |
| Number of Residues | 15 |
| Details | NA_DICARBOXYL_SYMP_1 Sodium:dicarboxylate symporter family signature 1. P.GElLLrLLRMIIlP |
| Chain | Residue | Details |
| A | PRO92-PRO106 |
| site_id | PS00714 |
| Number of Residues | 24 |
| Details | NA_DICARBOXYL_SYMP_2 Sodium:dicarboxylate symporter family signature 2. PiGaTvNMDGAaLFqcVaaVFIAQ |
| Chain | Residue | Details |
| A | PRO380-GLN403 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 423 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-ALA51 | |
| B | THR329-PRO333 | |
| B | GLU365-HIS373 | |
| B | GLN483-MET541 | |
| C | MET1-ALA51 | |
| C | ALA117-TRP130 | |
| C | GLY249-ARG257 | |
| C | THR329-PRO333 | |
| C | GLU365-HIS373 | |
| C | GLN483-MET541 | |
| A | ALA117-TRP130 | |
| A | GLY249-ARG257 | |
| A | THR329-PRO333 | |
| A | GLU365-HIS373 | |
| A | GLN483-MET541 | |
| B | MET1-ALA51 | |
| B | ALA117-TRP130 | |
| B | GLY249-ARG257 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 87 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000305|PubMed:29872227 |
| Chain | Residue | Details |
| A | ASN52-LEU81 | |
| B | ASN52-LEU81 | |
| C | ASN52-LEU81 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 378 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | GLY82-GLU94 | |
| B | LEU448-ASP460 | |
| C | GLY82-GLU94 | |
| C | GLN154-GLN224 | |
| C | ALA286-ILE306 | |
| C | ILE401-LYS413 | |
| C | LEU448-ASP460 | |
| A | GLN154-GLN224 | |
| A | ALA286-ILE306 | |
| A | ILE401-LYS413 | |
| A | LEU448-ASP460 | |
| B | GLY82-GLU94 | |
| B | GLN154-GLN224 | |
| B | ALA286-ILE306 | |
| B | ILE401-LYS413 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 63 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000305|PubMed:29872227 |
| Chain | Residue | Details |
| A | LEU95-ALA116 | |
| B | LEU95-ALA116 | |
| C | LEU95-ALA116 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 66 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000305|PubMed:29872227 |
| Chain | Residue | Details |
| A | ALA131-LEU153 | |
| B | ALA131-LEU153 | |
| C | ALA131-LEU153 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 69 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000305|PubMed:29872227 |
| Chain | Residue | Details |
| A | GLU225-LEU248 | |
| B | GLU225-LEU248 | |
| C | GLU225-LEU248 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 81 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000305|PubMed:29872227 |
| Chain | Residue | Details |
| A | PHE258-VAL285 | |
| B | PHE258-VAL285 | |
| C | PHE258-VAL285 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 63 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000305|PubMed:29872227 |
| Chain | Residue | Details |
| A | LEU307-PHE328 | |
| B | LEU307-PHE328 | |
| C | LEU307-PHE328 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 189 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000305|PubMed:29872227 |
| Chain | Residue | Details |
| A | TYR334-VAL364 | |
| A | ILE414-ASN447 | |
| B | TYR334-VAL364 | |
| B | ILE414-ASN447 | |
| C | TYR334-VAL364 | |
| C | ILE414-ASN447 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 78 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000305|PubMed:29872227 |
| Chain | Residue | Details |
| A | ILE374-PHE400 | |
| B | ILE374-PHE400 | |
| C | ILE374-PHE400 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 63 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000305|PubMed:29872227 |
| Chain | Residue | Details |
| A | TRP461-LEU482 | |
| B | TRP461-LEU482 | |
| C | TRP461-LEU482 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:O59010 |
| Chain | Residue | Details |
| A | GLY382 | |
| C | ASN386 | |
| C | ASN471 | |
| C | ASP475 | |
| A | ASN386 | |
| A | ASN471 | |
| A | ASP475 | |
| B | GLY382 | |
| B | ASN386 | |
| B | ASN471 | |
| B | ASP475 | |
| C | GLY382 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P43003 |
| Chain | Residue | Details |
| A | THR384 | |
| B | THR384 | |
| C | THR384 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 3 |
| Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | MET1 | |
| B | MET1 | |
| C | MET1 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER493 | |
| B | SER493 | |
| C | SER493 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR494 | |
| B | THR494 | |
| C | THR494 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | SER503 | |
| B | SER503 | |
| C | SER503 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER535 | |
| B | SER535 | |
| C | SER535 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER539 | |
| B | SER539 | |
| C | SER539 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN163 | |
| B | ASN163 | |
| C | ASN163 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| A | ASN212 | |
| B | ASN212 | |
| C | ASN212 |
