6RPR
LEM domain of Emerin mutant T43I in complex with BAF dimer and the Igfold of the lamin A/C
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| D | 0000785 | cellular_component | chromatin |
| D | 0000793 | cellular_component | condensed chromosome |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003690 | molecular_function | double-stranded DNA binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005635 | cellular_component | nuclear envelope |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005694 | cellular_component | chromosome |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006325 | biological_process | chromatin organization |
| D | 0006979 | biological_process | response to oxidative stress |
| D | 0007084 | biological_process | mitotic nuclear membrane reassembly |
| D | 0009615 | biological_process | response to virus |
| D | 0010836 | biological_process | negative regulation of protein ADP-ribosylation |
| D | 0032480 | biological_process | negative regulation of type I interferon production |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0045071 | biological_process | negative regulation of viral genome replication |
| D | 0045824 | biological_process | negative regulation of innate immune response |
| D | 0051276 | biological_process | chromosome organization |
| D | 0160049 | biological_process | negative regulation of cGAS/STING signaling pathway |
| E | 0000785 | cellular_component | chromatin |
| E | 0000793 | cellular_component | condensed chromosome |
| E | 0003677 | molecular_function | DNA binding |
| E | 0003690 | molecular_function | double-stranded DNA binding |
| E | 0005515 | molecular_function | protein binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005635 | cellular_component | nuclear envelope |
| E | 0005654 | cellular_component | nucleoplasm |
| E | 0005694 | cellular_component | chromosome |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006325 | biological_process | chromatin organization |
| E | 0006979 | biological_process | response to oxidative stress |
| E | 0007084 | biological_process | mitotic nuclear membrane reassembly |
| E | 0009615 | biological_process | response to virus |
| E | 0010836 | biological_process | negative regulation of protein ADP-ribosylation |
| E | 0032480 | biological_process | negative regulation of type I interferon production |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0042803 | molecular_function | protein homodimerization activity |
| E | 0045071 | biological_process | negative regulation of viral genome replication |
| E | 0045824 | biological_process | negative regulation of innate immune response |
| E | 0051276 | biological_process | chromosome organization |
| E | 0160049 | biological_process | negative regulation of cGAS/STING signaling pathway |
| G | 0005635 | cellular_component | nuclear envelope |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 D 101 |
| Chain | Residue |
| D | GLY27 |
| D | GLU28 |
| D | VAL29 |
| D | LEU30 |
| D | GLN73 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 D 102 |
| Chain | Residue |
| D | ARG60 |
| D | ARG75 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 D 103 |
| Chain | Residue |
| D | GLU28 |
| D | HOH212 |
| E | ARG60 |
| E | ARG75 |
| D | LYS6 |
| D | GLY27 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P48678","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24741066","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P48679","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 30 |
| Details | Domain: {"description":"HhH","evidences":[{"source":"PubMed","id":"10924106","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by VRK1 and VRK2","evidences":[{"source":"PubMed","id":"16495336","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by viral VacV B1 kinase, VRK1 and VRK2","evidences":[{"source":"PubMed","id":"16371512","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16495336","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
