6ROJ
Cryo-EM structure of the activated Drs2p-Cdc50p
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005215 | molecular_function | transporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005768 | cellular_component | endosome |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005802 | cellular_component | trans-Golgi network |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006892 | biological_process | post-Golgi vesicle-mediated transport |
| A | 0006897 | biological_process | endocytosis |
| A | 0008289 | molecular_function | lipid binding |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0015914 | biological_process | phospholipid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0032456 | biological_process | endocytic recycling |
| A | 0045332 | biological_process | phospholipid translocation |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070273 | molecular_function | phosphatidylinositol-4-phosphate binding |
| A | 0090555 | molecular_function | phosphatidylethanolamine flippase activity |
| A | 0090556 | molecular_function | phosphatidylserine floppase activity |
| A | 0140326 | molecular_function | ATPase-coupled intramembrane lipid transporter activity |
| A | 0140331 | biological_process | aminophospholipid translocation |
| A | 0140345 | molecular_function | phosphatidylcholine flippase activity |
| A | 0140346 | molecular_function | phosphatidylserine flippase activity |
| A | 1990530 | cellular_component | Cdc50p-Drs2p complex |
| A | 1990531 | cellular_component | phospholipid-translocating ATPase complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005768 | cellular_component | endosome |
| C | 0005783 | cellular_component | endoplasmic reticulum |
| C | 0005794 | cellular_component | Golgi apparatus |
| C | 0005802 | cellular_component | trans-Golgi network |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006886 | biological_process | intracellular protein transport |
| C | 0006897 | biological_process | endocytosis |
| C | 0015247 | molecular_function | aminophospholipid flippase activity |
| C | 0016020 | cellular_component | membrane |
| C | 0031902 | cellular_component | late endosome membrane |
| C | 0042147 | biological_process | retrograde transport, endosome to Golgi |
| C | 0045332 | biological_process | phospholipid translocation |
| C | 0051666 | biological_process | actin cortical patch localization |
| C | 0140331 | biological_process | aminophospholipid translocation |
| C | 1990530 | cellular_component | Cdc50p-Drs2p complex |
| C | 1990531 | cellular_component | phospholipid-translocating ATPase complex |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 81 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| C | MET1-SER44 | |
| C | LYS353-LEU391 | |
| A | VAL512-ILE1012 | |
| A | ASP1065-PHE1094 | |
| A | VAL1153-THR1161 | |
| A | LYS1224-ASP1355 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| C | VAL45-VAL65 | |
| C | LEU332-VAL352 | |
| A | ALA450-SER470 | |
| A | PHE491-PHE511 | |
| A | LEU1013-ASN1033 | |
| A | TRP1044-PHE1064 | |
| A | TRP1095-ILE1115 | |
| A | TRP1132-LEU1152 | |
| A | LEU1162-ILE1182 | |
| A | GLY1203-TRP1223 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 265 |
| Details | TOPO_DOM: Lumenal => ECO:0000255 |
| Chain | Residue | Details |
| C | SER66-SER331 | |
| A | THR471-LEU490 | |
| A | ALA1034-SER1043 | |
| A | TYR1116-HIS1131 | |
| A | PHE1183-SER1202 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:31243363, ECO:0000269|PubMed:31515475 |
| Chain | Residue | Details |
| C | ASN199 | |
| C | ASN288 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:31243363, ECO:0000269|PubMed:31515475, ECO:0007744|PDB:7OH6, ECO:0007744|PDB:7OH7 |
| Chain | Residue | Details |
| A | LYS561 | |
| A | THR562 | |
| A | PHE698 | |
| A | ASP954 | |
| A | ASN957 | |
| C | ASN216 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:31243363 |
| Chain | Residue | Details |
| A | LYS721 | |
| A | ARG755 | |
| A | GLY836 | |
| A | ASP837 | |
| A | ARG928 | |
| A | LYS934 | |
| C | ASN237 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| C | ASN329 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34023399, ECO:0007744|PDB:7OH5, ECO:0007744|PDB:7OH7 |
| Chain | Residue | Details |
| A | LYS703 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34023399, ECO:0007744|PDB:7OH5 |
| Chain | Residue | Details |
| A | THR756 | |
| A | THR835 | |
| A | LYS1149 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q8NB49 |
| Chain | Residue | Details |
| A | ASP958 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31243363, ECO:0000269|PubMed:34023399, ECO:0007744|PDB:6ROI, ECO:0007744|PDB:7OH4, ECO:0007744|PDB:7OH5, ECO:0007744|PDB:7OH6 |
| Chain | Residue | Details |
| A | ARG1219 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31243363, ECO:0000269|PubMed:34023399, ECO:0007744|PDB:6ROI, ECO:0007744|PDB:7OH4, ECO:0007744|PDB:7OH7 |
| Chain | Residue | Details |
| A | TRP1223 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31243363, ECO:0000269|PubMed:34023399, ECO:0007744|PDB:6ROI, ECO:0007744|PDB:6ROJ, ECO:0007744|PDB:7OH4, ECO:0007744|PDB:7OH5, ECO:0007744|PDB:7OH6 |
| Chain | Residue | Details |
| A | LYS1224 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31243363, ECO:0000269|PubMed:34023399, ECO:0007744|PDB:6ROI, ECO:0007744|PDB:7OH7 |
| Chain | Residue | Details |
| A | TYR1235 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31243363, ECO:0000269|PubMed:34023399, ECO:0007744|PDB:6ROI, ECO:0007744|PDB:6ROJ, ECO:0007744|PDB:7OH4, ECO:0007744|PDB:7OH5, ECO:0007744|PDB:7OH6, ECO:0007744|PDB:7OH7 |
| Chain | Residue | Details |
| A | HIS1236 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | SITE: Involved in the release of the transported lipid into the cytosolic leaflet => ECO:0000250|UniProtKB:C7EXK4 |
| Chain | Residue | Details |
| A | ILE508 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| A | SER102 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-biotinyllysine => ECO:0000250, ECO:0000255|PROSITE-ProRule:PRU01066 |
| Chain | Residue | Details |
| A | LYS1434 |
