6RMV
The crystal structure of a TRP channel peptide bound to a G protein beta gamma heterodimer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001750 | cellular_component | photoreceptor outer segment |
| A | 0001917 | cellular_component | photoreceptor inner segment |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005834 | cellular_component | heterotrimeric G-protein complex |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| A | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| A | 0007603 | biological_process | phototransduction, visible light |
| A | 0008283 | biological_process | cell population proliferation |
| A | 0010659 | biological_process | cardiac muscle cell apoptotic process |
| A | 0030159 | molecular_function | signaling receptor complex adaptor activity |
| A | 0030425 | cellular_component | dendrite |
| A | 0030507 | molecular_function | spectrin binding |
| A | 0042622 | cellular_component | photoreceptor outer segment membrane |
| A | 0043209 | cellular_component | myelin sheath |
| A | 0044297 | cellular_component | cell body |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0045202 | cellular_component | synapse |
| A | 0047391 | molecular_function | alkylglycerophosphoethanolamine phosphodiesterase activity |
| A | 0050909 | biological_process | sensory perception of taste |
| A | 0051020 | molecular_function | GTPase binding |
| A | 0060041 | biological_process | retina development in camera-type eye |
| A | 0071456 | biological_process | cellular response to hypoxia |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005834 | cellular_component | heterotrimeric G-protein complex |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0008283 | biological_process | cell population proliferation |
| B | 0031681 | molecular_function | G-protein beta-subunit binding |
| B | 0045202 | cellular_component | synapse |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 101 |
| Chain | Residue |
| A | ASN340 |
| B | PRO49 |
| B | VAL54 |
| B | ASN59 |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| A | LEU70-SER84 | |
| A | ILE157-ILE171 | |
| A | LEU285-ALA299 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | Repeat: {"description":"WD 1","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 45 |
| Details | Repeat: {"description":"WD 2","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"WD 3","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 4","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"WD 5","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 6","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 30 |
| Details | Repeat: {"description":"WD 7","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Cysteine methyl ester","evidences":[{"source":"UniProtKB","id":"P63212","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"S-geranylgeranyl cysteine","evidences":[{"source":"UniProtKB","id":"P63212","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | Region: {"description":"Required for the inhibitory action of G-beta/gamma-subunits of heterotrimeric G-proteins","evidences":[{"source":"PubMed","id":"33122432","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
