6RCT

Crystal structure of CLK3 in complex with T3-CLK

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue JWN A 501

Chain	Residue
A	ASN161
A	ASP320
A	LEU162
A	ALA184
A	LYS186
A	PHE236
A	GLU237
A	LEU239
A	GLY240
A	LEU290

---

site_id	AC2
Number of Residues	5
Details	binding site for residue EDO A 502

Chain	Residue
A	LEU218
A	GLN266
A	SER315
A	ARG317
A	PHE482

---

site_id	AC3
Number of Residues	2
Details	binding site for residue EDO A 503

Chain	Residue
A	VAL145
A	TRP151

---

site_id	AC4
Number of Residues	2
Details	binding site for residue EDO A 504

Chain	Residue
A	PRO254
A	GLU308

---

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO A 505

Chain	Residue
A	ASP327
A	HIS328
B	GLU416

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 506

Chain	Residue
A	ASP327
A	GLU329
A	HOH628
B	ARG422
B	LYS425

---

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO A 507

Chain	Residue
A	ARG451
A	GLN459
A	ILE461
A	GLU465

---

site_id	AC8
Number of Residues	12
Details	binding site for residue JWN B 501

Chain	Residue
B	ASN161
B	LEU162
B	ALA184
B	LYS186
B	GLU201
B	PHE236
B	GLU237
B	LEU239
B	GLY240
B	LYS241
B	LEU290
B	ASP320

---

site_id	AC9
Number of Residues	3
Details	binding site for residue EDO B 502

Chain	Residue
B	VAL413
B	TRP414
B	GLU416

---

site_id	AD1
Number of Residues	6
Details	binding site for residue EDO B 503

Chain	Residue
A	ARG400
B	HIS339
B	GLN375
B	THR376
B	HIS377
B	HOH612

---

site_id	AD2
Number of Residues	6
Details	binding site for residue EDO B 504

Chain	Residue
B	ILE208
B	ASN215
B	CYS219
B	VAL220
B	LEU221
B	MET222

---

site_id	AD3
Number of Residues	2
Details	binding site for residue EDO B 505

Chain	Residue
B	TYR265
B	HIS269

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGTFGKVVeCldhargksq.........VALK

Chain	Residue	Details
A	LEU162-LYS186

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LtHtDLKpeNILF

Chain	Residue	Details
A	LEU279-PHE291

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	632
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---