6R75

Crystal structure of human Ube2T E54R mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000209	biological_process	protein polyubiquitination
A	0003682	molecular_function	chromatin binding
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0006281	biological_process	DNA repair
A	0006513	biological_process	protein monoubiquitination
A	0006974	biological_process	DNA damage response
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0019787	molecular_function	ubiquitin-like protein transferase activity
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032446	biological_process	protein modification by small protein conjugation
A	0035519	biological_process	protein K29-linked ubiquitination
A	0044314	biological_process	protein K27-linked ubiquitination
A	0051865	biological_process	protein autoubiquitination
A	0061631	molecular_function	ubiquitin conjugating enzyme activity
A	0070534	biological_process	protein K63-linked ubiquitination
A	0070936	biological_process	protein K48-linked ubiquitination
A	0070979	biological_process	protein K11-linked ubiquitination
A	0085020	biological_process	protein K6-linked ubiquitination

Functional Information from PROSITE/UniProt

site_id	PS00183
Number of Residues	16
Details	UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNIdsa.GrICLdvL

Chain	Residue	Details
A	TYR75-LEU90

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	150
Details	Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"16916645","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111657","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---