Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6QL9

Structure of Fatty acid synthase complex from Saccharomyces cerevisiae at 2.9 Angstrom

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0004312	molecular_function	fatty acid synthase activity
A	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
A	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A	0004321	molecular_function	fatty-acyl-CoA synthase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005835	cellular_component	fatty acid synthase complex
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0042759	biological_process	long-chain fatty acid biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0004312	molecular_function	fatty acid synthase activity
B	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
B	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B	0004321	molecular_function	fatty-acyl-CoA synthase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005835	cellular_component	fatty acid synthase complex
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0042759	biological_process	long-chain fatty acid biosynthetic process
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0003824	molecular_function	catalytic activity
C	0004312	molecular_function	fatty acid synthase activity
C	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
C	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
C	0004321	molecular_function	fatty-acyl-CoA synthase activity
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0005835	cellular_component	fatty acid synthase complex
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
C	0016491	molecular_function	oxidoreductase activity
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0042759	biological_process	long-chain fatty acid biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0004312	molecular_function	fatty acid synthase activity
D	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
D	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
D	0004321	molecular_function	fatty-acyl-CoA synthase activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0005835	cellular_component	fatty acid synthase complex
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
D	0016491	molecular_function	oxidoreductase activity
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0042759	biological_process	long-chain fatty acid biosynthetic process
D	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0003824	molecular_function	catalytic activity
E	0004312	molecular_function	fatty acid synthase activity
E	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
E	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
E	0004321	molecular_function	fatty-acyl-CoA synthase activity
E	0005515	molecular_function	protein binding
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0005835	cellular_component	fatty acid synthase complex
E	0006629	biological_process	lipid metabolic process
E	0006631	biological_process	fatty acid metabolic process
E	0006633	biological_process	fatty acid biosynthetic process
E	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
E	0016491	molecular_function	oxidoreductase activity
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0042759	biological_process	long-chain fatty acid biosynthetic process
E	0046872	molecular_function	metal ion binding
F	0000287	molecular_function	magnesium ion binding
F	0003824	molecular_function	catalytic activity
F	0004312	molecular_function	fatty acid synthase activity
F	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
F	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
F	0004321	molecular_function	fatty-acyl-CoA synthase activity
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0005835	cellular_component	fatty acid synthase complex
F	0006629	biological_process	lipid metabolic process
F	0006631	biological_process	fatty acid metabolic process
F	0006633	biological_process	fatty acid biosynthetic process
F	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
F	0016491	molecular_function	oxidoreductase activity
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0042759	biological_process	long-chain fatty acid biosynthetic process
F	0046872	molecular_function	metal ion binding
G	0003824	molecular_function	catalytic activity
G	0004312	molecular_function	fatty acid synthase activity
G	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
G	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
G	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G	0004321	molecular_function	fatty-acyl-CoA synthase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005811	cellular_component	lipid droplet
G	0005829	cellular_component	cytosol
G	0005835	cellular_component	fatty acid synthase complex
G	0006629	biological_process	lipid metabolic process
G	0006631	biological_process	fatty acid metabolic process
G	0006633	biological_process	fatty acid biosynthetic process
G	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
G	0016409	molecular_function	palmitoyltransferase activity
G	0016491	molecular_function	oxidoreductase activity
G	0016740	molecular_function	transferase activity
G	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
G	0016787	molecular_function	hydrolase activity
G	0016829	molecular_function	lyase activity
G	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
G	0042759	biological_process	long-chain fatty acid biosynthetic process
G	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
H	0003824	molecular_function	catalytic activity
H	0004312	molecular_function	fatty acid synthase activity
H	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
H	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
H	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H	0004321	molecular_function	fatty-acyl-CoA synthase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005811	cellular_component	lipid droplet
H	0005829	cellular_component	cytosol
H	0005835	cellular_component	fatty acid synthase complex
H	0006629	biological_process	lipid metabolic process
H	0006631	biological_process	fatty acid metabolic process
H	0006633	biological_process	fatty acid biosynthetic process
H	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
H	0016409	molecular_function	palmitoyltransferase activity
H	0016491	molecular_function	oxidoreductase activity
H	0016740	molecular_function	transferase activity
H	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
H	0016787	molecular_function	hydrolase activity
H	0016829	molecular_function	lyase activity
H	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
H	0042759	biological_process	long-chain fatty acid biosynthetic process
H	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
I	0003824	molecular_function	catalytic activity
I	0004312	molecular_function	fatty acid synthase activity
I	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
I	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
I	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I	0004321	molecular_function	fatty-acyl-CoA synthase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005811	cellular_component	lipid droplet
I	0005829	cellular_component	cytosol
I	0005835	cellular_component	fatty acid synthase complex
I	0006629	biological_process	lipid metabolic process
I	0006631	biological_process	fatty acid metabolic process
I	0006633	biological_process	fatty acid biosynthetic process
I	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
I	0016409	molecular_function	palmitoyltransferase activity
I	0016491	molecular_function	oxidoreductase activity
I	0016740	molecular_function	transferase activity
I	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
I	0016787	molecular_function	hydrolase activity
I	0016829	molecular_function	lyase activity
I	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
I	0042759	biological_process	long-chain fatty acid biosynthetic process
I	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
J	0003824	molecular_function	catalytic activity
J	0004312	molecular_function	fatty acid synthase activity
J	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
J	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
J	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J	0004321	molecular_function	fatty-acyl-CoA synthase activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005811	cellular_component	lipid droplet
J	0005829	cellular_component	cytosol
J	0005835	cellular_component	fatty acid synthase complex
J	0006629	biological_process	lipid metabolic process
J	0006631	biological_process	fatty acid metabolic process
J	0006633	biological_process	fatty acid biosynthetic process
J	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
J	0016409	molecular_function	palmitoyltransferase activity
J	0016491	molecular_function	oxidoreductase activity
J	0016740	molecular_function	transferase activity
J	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
J	0016787	molecular_function	hydrolase activity
J	0016829	molecular_function	lyase activity
J	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
J	0042759	biological_process	long-chain fatty acid biosynthetic process
J	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
K	0003824	molecular_function	catalytic activity
K	0004312	molecular_function	fatty acid synthase activity
K	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
K	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
K	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K	0004321	molecular_function	fatty-acyl-CoA synthase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005811	cellular_component	lipid droplet
K	0005829	cellular_component	cytosol
K	0005835	cellular_component	fatty acid synthase complex
K	0006629	biological_process	lipid metabolic process
K	0006631	biological_process	fatty acid metabolic process
K	0006633	biological_process	fatty acid biosynthetic process
K	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
K	0016409	molecular_function	palmitoyltransferase activity
K	0016491	molecular_function	oxidoreductase activity
K	0016740	molecular_function	transferase activity
K	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
K	0016787	molecular_function	hydrolase activity
K	0016829	molecular_function	lyase activity
K	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
K	0042759	biological_process	long-chain fatty acid biosynthetic process
K	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
L	0003824	molecular_function	catalytic activity
L	0004312	molecular_function	fatty acid synthase activity
L	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
L	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
L	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L	0004321	molecular_function	fatty-acyl-CoA synthase activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005811	cellular_component	lipid droplet
L	0005829	cellular_component	cytosol
L	0005835	cellular_component	fatty acid synthase complex
L	0006629	biological_process	lipid metabolic process
L	0006631	biological_process	fatty acid metabolic process
L	0006633	biological_process	fatty acid biosynthetic process
L	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
L	0016409	molecular_function	palmitoyltransferase activity
L	0016491	molecular_function	oxidoreductase activity
L	0016740	molecular_function	transferase activity
L	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
L	0016787	molecular_function	hydrolase activity
L	0016829	molecular_function	lyase activity
L	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
L	0042759	biological_process	long-chain fatty acid biosynthetic process
L	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue PNS A 1901

Chain	Residue
A	SER180
F	THR1546
F	ASN1549
F	HIS1583
F	PHE1644
F	PHE1646
A	ASN184
F	CYS1305
F	MET1346
F	SER1417
F	PRO1419
F	ALA1420
F	HIS1542
F	THR1544

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO A 1902

Chain	Residue
A	LEU1110
A	PHE1111
A	GLN1380
A	EDO1909

site_id	AC3
Number of Residues	1
Details	binding site for residue EDO A 1903

Chain	Residue
A	LYS398

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 1904

Chain	Residue
A	PHE1223
A	ILE1228
A	THR1229
A	PRO1231
A	LEU1697

site_id	AC5
Number of Residues	2
Details	binding site for residue EDO A 1905

Chain	Residue
A	MET1057
A	PHE1059

site_id	AC6
Number of Residues	3
Details	binding site for residue EDO A 1906

Chain	Residue
A	GLY1635
A	VAL1636
A	HIS1657

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO A 1907

Chain	Residue
A	ASP492
A	GLU691
A	GLN694
A	GLN698

site_id	AC8
Number of Residues	2
Details	binding site for residue EDO A 1908

Chain	Residue
A	GLU935
F	HIS854

site_id	AC9
Number of Residues	4
Details	binding site for residue EDO A 1909

Chain	Residue
A	ASN1194
A	ALA1195
A	LEU1213
A	EDO1902

site_id	AD1
Number of Residues	3
Details	binding site for residue EDO A 1910

Chain	Residue
A	MET1251
A	SER1278
E	MET1251

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO A 1911

Chain	Residue
A	HIS335
A	GLN342
B	HIS335
B	GLN342
C	GLN342

site_id	AD3
Number of Residues	5
Details	binding site for residue NA A 1912

Chain	Residue
A	ARG985
A	GLU1048
G	ARG957
G	THR959
G	LYS960

site_id	AD4
Number of Residues	5
Details	binding site for residue NA A 1913

Chain	Residue
A	ILE1106
A	TYR1114
A	PHE1181
A	ARG1183
A	SER1340

site_id	AD5
Number of Residues	4
Details	binding site for residue NA A 1914

Chain	Residue
A	ARG1034
A	GLU1052
A	TYR1198
A	GLU1221

site_id	AD6
Number of Residues	3
Details	binding site for residue NA A 1915

Chain	Residue
A	SER1206
A	GLN1271
A	HOH2007

site_id	AD7
Number of Residues	4
Details	binding site for residue NA A 1916

Chain	Residue
A	ASP1209
A	THR1212
A	GLU1277
A	MET1283

site_id	AD8
Number of Residues	4
Details	binding site for residue NA A 1917

Chain	Residue
A	ASP1209
A	VAL1254
A	SER1255
A	ASP1334

site_id	AD9
Number of Residues	12
Details	binding site for residue A2P A 1918

Chain	Residue
A	GLY682
A	GLY684
A	SER687
A	THR707
A	SER708
A	ARG709
A	PHE737
A	ASN738
A	GLN739
A	ALA772
A	ALA773
A	ILE774

site_id	AE1
Number of Residues	14
Details	binding site for residue PNS B 1901

Chain	Residue
B	SER180
E	CYS1305
E	MET1346
E	SER1417
E	PRO1419
E	ALA1420
E	HIS1542
E	THR1544
E	THR1546
E	ALA1548
E	ASN1549
E	HIS1583
E	PHE1644
E	PHE1646

site_id	AE2
Number of Residues	2
Details	binding site for residue ACT B 1902

Chain	Residue
B	HIS1358
B	ARG396

site_id	AE3
Number of Residues	4
Details	binding site for residue EDO B 1904

Chain	Residue
B	LYS1145
B	ASP1153
B	ILE1154
C	ARG359

site_id	AE4
Number of Residues	3
Details	binding site for residue EDO B 1905

Chain	Residue
B	ILE1004
B	GLY1635
B	VAL1636

site_id	AE5
Number of Residues	4
Details	binding site for residue EDO B 1906

Chain	Residue
B	LEU1110
B	PHE1111
B	GLN1380
B	EDO1907

site_id	AE6
Number of Residues	2
Details	binding site for residue EDO B 1907

Chain	Residue
B	TRP1193
B	EDO1906

site_id	AE7
Number of Residues	3
Details	binding site for residue EDO B 1908

Chain	Residue
B	HIS454
B	ILE1573
B	GLY1635

site_id	AE8
Number of Residues	3
Details	binding site for residue EDO B 1909

Chain	Residue
B	MET1057
B	PHE1059
B	HIS1100

site_id	AE9
Number of Residues	3
Details	binding site for residue EDO B 1910

Chain	Residue
B	SER1206
B	VAL1208
B	GLN1271

site_id	AF1
Number of Residues	5
Details	binding site for residue EDO B 1911

Chain	Residue
B	MET1251
B	SER1278
D	MET1251
D	SER1278
D	HOH2014

site_id	AF2
Number of Residues	1
Details	binding site for residue EDO B 1912

Chain	Residue
B	THR1197

site_id	AF3
Number of Residues	4
Details	binding site for residue NA B 1913

Chain	Residue
B	ARG985
B	GLU1048
H	ARG957
H	THR959

site_id	AF4
Number of Residues	4
Details	binding site for residue NA B 1914

Chain	Residue
B	GLY1252
B	VAL1254
B	ASP1333
B	ASP1334

site_id	AF5
Number of Residues	4
Details	binding site for residue NA B 1915

Chain	Residue
B	TYR1513
B	LYS1514
B	ASP1516
B	ILE1519

site_id	AF6
Number of Residues	5
Details	binding site for residue NA B 1916

Chain	Residue
B	SER1540
B	PHE1541
B	VAL1575
B	GLN1577
B	MET1592

site_id	AF7
Number of Residues	3
Details	binding site for residue NA B 1917

Chain	Residue
B	ASP1209
B	THR1212
B	GLU1277

site_id	AF8
Number of Residues	9
Details	binding site for residue A2P B 1918

Chain	Residue
B	GLY682
B	GLY684
B	THR707
B	SER708
B	ARG709
B	ASN738
B	GLN739
B	ALA773
B	ILE774

site_id	AF9
Number of Residues	15
Details	binding site for residue PNS C 1901

Chain	Residue
C	SER180
C	ASN184
D	CYS1305
D	MET1346
D	SER1417
D	PRO1419
D	ALA1420
D	HIS1542
D	THR1544
D	THR1546
D	ALA1548
D	ASN1549
D	HIS1583
D	PHE1644
D	PHE1646

site_id	AG1
Number of Residues	2
Details	binding site for residue ACT C 1902

Chain	Residue
C	GLY1635
C	TYR1660

site_id	AG2
Number of Residues	3
Details	binding site for residue ACT C 1903

Chain	Residue
C	MET440
C	LYS491
C	LEU616

site_id	AG3
Number of Residues	2
Details	binding site for residue EDO C 1904

Chain	Residue
C	HIS454
C	GLY1635

site_id	AG4
Number of Residues	4
Details	binding site for residue EDO C 1905

Chain	Residue
C	LEU1110
C	PHE1111
C	ILE1189
C	GLN1380

site_id	AG5
Number of Residues	1
Details	binding site for residue EDO C 1906

Chain	Residue
C	THR1191

site_id	AG6
Number of Residues	3
Details	binding site for residue EDO C 1907

Chain	Residue
C	SER1206
C	VAL1208
C	GLN1271

site_id	AG7
Number of Residues	1
Details	binding site for residue EDO C 1908

Chain	Residue
C	GLN809

site_id	AG8
Number of Residues	4
Details	binding site for residue EDO C 1909

Chain	Residue
C	LYS643
C	ASN851
D	PRO828
D	HIS830

site_id	AG9
Number of Residues	2
Details	binding site for residue EDO C 1910

Chain	Residue
C	ARG1360
C	THR1361

site_id	AH1
Number of Residues	4
Details	binding site for residue EDO C 1911

Chain	Residue
C	MET1251
C	SER1278
F	MET1251
F	SER1278

site_id	AH2
Number of Residues	2
Details	binding site for residue EDO C 1912

Chain	Residue
C	THR1428
C	ARG1430

site_id	AH3
Number of Residues	5
Details	binding site for residue NA C 1913

Chain	Residue
C	ARG985
C	GLU1048
I	ARG957
I	THR959
I	LYS960

site_id	AH4
Number of Residues	3
Details	binding site for residue NA C 1914

Chain	Residue
C	GLU1026
C	GLY1028
C	ARG1036

site_id	AH5
Number of Residues	4
Details	binding site for residue NA C 1915

Chain	Residue
C	ARG1034
C	GLU1052
C	TYR1198
C	GLU1221

site_id	AH6
Number of Residues	4
Details	binding site for residue NA C 1916

Chain	Residue
C	ASP1209
C	THR1212
C	GLU1277
C	MET1283

site_id	AH7
Number of Residues	11
Details	binding site for residue A2P C 1917

Chain	Residue
C	GLY682
C	GLY684
C	SER687
C	THR707
C	SER708
C	PHE737
C	ASN738
C	GLN739
C	ALA772
C	ALA773
C	ILE774

site_id	AH8
Number of Residues	3
Details	binding site for residue EDO D 1902

Chain	Residue
D	LYS397
D	HIS1358
D	THR1372

site_id	AH9
Number of Residues	1
Details	binding site for residue EDO D 1903

Chain	Residue
D	LYS398

site_id	AI1
Number of Residues	3
Details	binding site for residue EDO D 1904

Chain	Residue
D	LYS1145
D	ASP1153
D	ILE1154

site_id	AI2
Number of Residues	3
Details	binding site for residue EDO D 1905

Chain	Residue
D	ILE1004
D	GLY1635
D	HIS1657

site_id	AI3
Number of Residues	2
Details	binding site for residue EDO D 1906

Chain	Residue
D	ASN1194
D	ALA1195

site_id	AI4
Number of Residues	4
Details	binding site for residue EDO D 1907

Chain	Residue
D	LEU1110
D	ILE1189
D	PRO1190
D	GLN1380

site_id	AI5
Number of Residues	3
Details	binding site for residue EDO D 1908

Chain	Residue
D	HIS454
D	GLY1635
D	EDO1909

site_id	AI6
Number of Residues	3
Details	binding site for residue EDO D 1909

Chain	Residue
D	TYR417
D	HIS454
D	EDO1908

site_id	AI7
Number of Residues	5
Details	binding site for residue EDO D 1910

Chain	Residue
D	ASP492
D	GLU691
D	GLN694
D	GLN698
D	LYS899

site_id	AI8
Number of Residues	2
Details	binding site for residue EDO D 1911

Chain	Residue
D	MET1057
D	THR1191

site_id	AI9
Number of Residues	1
Details	binding site for residue EDO D 1912

Chain	Residue
D	THR1197

site_id	AJ1
Number of Residues	1
Details	binding site for residue EDO D 1913

Chain	Residue
D	GLU935

site_id	AJ2
Number of Residues	3
Details	binding site for residue EDO D 1914

Chain	Residue
D	ILE1228
D	THR1229
D	LEU1697

site_id	AJ3
Number of Residues	4
Details	binding site for residue NA D 1915

Chain	Residue
D	ARG985
D	GLU1048
J	ARG957
J	THR959

site_id	AJ4
Number of Residues	3
Details	binding site for residue NA D 1916

Chain	Residue
D	SER1206
D	VAL1208
D	GLN1271

site_id	AJ5
Number of Residues	4
Details	binding site for residue NA D 1917

Chain	Residue
D	ARG400
D	THR715
D	ARG1360
D	ASP1612

site_id	AJ6
Number of Residues	3
Details	binding site for residue NA D 1918

Chain	Residue
D	GLU1026
D	GLY1028
D	ARG1036

site_id	AJ7
Number of Residues	4
Details	binding site for residue NA D 1919

Chain	Residue
D	ASP1209
D	THR1212
D	GLU1277
D	MET1283

site_id	AJ8
Number of Residues	2
Details	binding site for residue NA D 1920

Chain	Residue
D	SER1340
D	GLU1378

site_id	AJ9
Number of Residues	3
Details	binding site for residue NA D 1921

Chain	Residue
D	ASP716
D	GLN719
D	ARG1609

site_id	AK1
Number of Residues	5
Details	binding site for residue NA D 1922

Chain	Residue
D	ILE1106
D	TYR1114
D	PHE1181
D	ARG1183
D	SER1340

site_id	AK2
Number of Residues	10
Details	binding site for residue A2P D 1923

Chain	Residue
D	GLY682
D	GLY684
D	THR707
D	SER708
D	ARG709
D	ASN738
D	GLN739
D	ALA772
D	ALA773
D	ILE774

site_id	AK3
Number of Residues	3
Details	binding site for residue EDO E 1902

Chain	Residue
A	LYS1323
E	THR1428
E	ARG1430

site_id	AK4
Number of Residues	1
Details	binding site for residue EDO E 1903

Chain	Residue
E	GLY1635

site_id	AK5
Number of Residues	4
Details	binding site for residue EDO E 1904

Chain	Residue
E	ILE1004
E	VAL1636
E	HIS1657
E	EDO1911

site_id	AK6
Number of Residues	3
Details	binding site for residue EDO E 1905

Chain	Residue
E	LEU1110
E	ILE1189
E	GLN1380

site_id	AK7
Number of Residues	3
Details	binding site for residue EDO E 1906

Chain	Residue
E	ARG1183
E	ASN1351
E	GLU1354

site_id	AK8
Number of Residues	4
Details	binding site for residue EDO E 1907

Chain	Residue
E	MET1057
E	PHE1059
E	THR1191
E	HOH2003

site_id	AK9
Number of Residues	3
Details	binding site for residue EDO E 1908

Chain	Residue
E	LYS37
E	LYS64
E	TYR65

site_id	AL1
Number of Residues	2
Details	binding site for residue EDO E 1909

Chain	Residue
B	HIS854
E	GLU935

site_id	AL2
Number of Residues	5
Details	binding site for residue EDO E 1910

Chain	Residue
D	HIS335
D	GLN342
E	HIS335
E	GLN342
F	HIS335

site_id	AL3
Number of Residues	4
Details	binding site for residue EDO E 1911

Chain	Residue
E	LYS462
E	ASP1634
E	ARG1637
E	EDO1904

site_id	AL4
Number of Residues	2
Details	binding site for residue EDO E 1912

Chain	Residue
E	ASN1601
E	HIS1657

site_id	AL5
Number of Residues	4
Details	binding site for residue EDO E 1913

Chain	Residue
E	ASP991
E	TRP1037
E	GLN1598
E	SER1602

site_id	AL6
Number of Residues	4
Details	binding site for residue NA E 1914

Chain	Residue
E	ARG985
E	GLU1048
K	ARG957
K	THR959

site_id	AL7
Number of Residues	5
Details	binding site for residue NA E 1915

Chain	Residue
E	TYR1513
E	LYS1514
E	ASP1516
E	ILE1519
E	HOH2024

site_id	AL8
Number of Residues	2
Details	binding site for residue NA E 1916

Chain	Residue
E	LEU1098
E	SER1101

site_id	AL9
Number of Residues	11
Details	binding site for residue A2P E 1917

Chain	Residue
E	GLY682
E	GLY684
E	SER687
E	THR707
E	SER708
E	PHE737
E	ASN738
E	GLN739
E	ALA772
E	ALA773
E	ILE774

site_id	AM1
Number of Residues	1
Details	binding site for residue PGE E 1918

Chain	Residue
E	MET352

site_id	AM2
Number of Residues	1
Details	binding site for residue EDO F 1902

Chain	Residue
F	LYS398

site_id	AM3
Number of Residues	2
Details	binding site for residue EDO F 1903

Chain	Residue
F	ILE1004
F	GLY1635

site_id	AM4
Number of Residues	1
Details	binding site for residue EDO F 1904

Chain	Residue
F	ASN1194

site_id	AM5
Number of Residues	3
Details	binding site for residue EDO F 1905

Chain	Residue
F	THR401
F	GLY759
F	GLY760

site_id	AM6
Number of Residues	2
Details	binding site for residue EDO F 1906

Chain	Residue
F	ASP764
F	ARG818

site_id	AM7
Number of Residues	5
Details	binding site for residue EDO F 1907

Chain	Residue
F	PHE1223
F	ILE1228
F	THR1229
F	PRO1231
F	LEU1697

site_id	AM8
Number of Residues	4
Details	binding site for residue EDO F 1908

Chain	Residue
C	GLU1142
C	HIS1146
F	ALA1178
F	ARG1180

site_id	AM9
Number of Residues	4
Details	binding site for residue EDO F 1909

Chain	Residue
F	LEU1110
F	ILE1189
F	PHE1214
F	GLN1380

site_id	AN1
Number of Residues	3
Details	binding site for residue NA F 1910

Chain	Residue
F	GLU1026
F	GLY1028
F	ARG1036

site_id	AN2
Number of Residues	4
Details	binding site for residue NA F 1911

Chain	Residue
F	SER615
F	ASN618
F	SER620
F	PHE668

site_id	AN3
Number of Residues	11
Details	binding site for residue A2P F 1912

Chain	Residue
F	GLY682
F	GLY684
F	THR706
F	THR707
F	SER708
F	ASN738
F	GLN739
F	ALA772
F	ALA773
F	ILE774
F	ILE794

site_id	AN4
Number of Residues	18
Details	binding site for residue FMN G 2101

Chain	Residue
G	PRO595
G	GLY596
G	MET597
G	THR598
G	ASN650
G	ILE652
G	GLY682
G	LYS706
G	THR733
G	GLY737
G	GLY738
G	GLY739
G	SER769
G	GLY770
G	GLY802
G	SER803
G	LEU1054
G	ALA1059

site_id	AN5
Number of Residues	7
Details	binding site for residue MLI G 2102

Chain	Residue
G	GLN1669
G	SER1808
G	LEU1809
G	ARG1834
G	PHE1976
G	HIS1977
G	HOH2209

site_id	AN6
Number of Residues	1
Details	binding site for residue NA G 2103

Chain	Residue
G	ASP913

site_id	AN7
Number of Residues	5
Details	binding site for residue NA G 2104

Chain	Residue
G	ILE821
G	ALA822
G	CYS824
G	ALA1060
G	THR1063

site_id	AN8
Number of Residues	17
Details	binding site for residue FMN H 2101

Chain	Residue
H	PRO595
H	GLY596
H	MET597
H	THR598
H	ASN650
H	GLY682
H	LYS706
H	THR733
H	GLY737
H	GLY738
H	GLY739
H	SER769
H	GLY770
H	GLY802
H	SER803
H	LEU1054
H	ALA1059

site_id	AN9
Number of Residues	1
Details	binding site for residue ACT H 2102

Chain	Residue
H	ASP1001

site_id	AO1
Number of Residues	2
Details	binding site for residue ACT H 2103

Chain	Residue
H	GLY842
H	ALA858

site_id	AO2
Number of Residues	3
Details	binding site for residue ACT H 2104

Chain	Residue
H	MET1433
H	HIS1434
H	ASN1523

site_id	AO3
Number of Residues	2
Details	binding site for residue EDO H 2105

Chain	Residue
H	ARG952
H	TYR970

site_id	AO4
Number of Residues	1
Details	binding site for residue NA H 2106

Chain	Residue
H	ASP913

site_id	AO5
Number of Residues	5
Details	binding site for residue NA H 2107

Chain	Residue
H	ILE821
H	ALA822
H	CYS824
H	ALA1060
H	THR1063

site_id	AO6
Number of Residues	17
Details	binding site for residue FMN I 2101

Chain	Residue
I	PRO595
I	GLY596
I	MET597
I	THR598
I	ASN650
I	GLY682
I	LYS706
I	THR733
I	GLY737
I	GLY738
I	GLY739
I	SER769
I	GLY770
I	GLY802
I	SER803
I	LEU1054
I	ALA1059

site_id	AO7
Number of Residues	5
Details	binding site for residue NA I 2102

Chain	Residue
I	ILE821
I	ALA822
I	CYS824
I	ALA1060
I	THR1063

site_id	AO8
Number of Residues	19
Details	binding site for residue FMN J 2101

Chain	Residue
J	PRO595
J	GLY596
J	MET597
J	THR598
J	ASN650
J	ILE652
J	GLY682
J	LYS706
J	THR733
J	GLY737
J	GLY738
J	GLY739
J	SER769
J	GLY770
J	LEU800
J	GLY802
J	SER803
J	LEU1054
J	ALA1059

site_id	AO9
Number of Residues	7
Details	binding site for residue MLI J 2102

Chain	Residue
J	GLY1668
J	GLN1669
J	SER1808
J	LEU1809
J	ARG1834
J	MET1838
J	PHE1976

site_id	AP1
Number of Residues	2
Details	binding site for residue EDO J 2103

Chain	Residue
J	ARG952
J	TYR970

site_id	AP2
Number of Residues	2
Details	binding site for residue EDO J 2104

Chain	Residue
J	PHE743
J	ARG847

site_id	AP3
Number of Residues	2
Details	binding site for residue EDO J 2105

Chain	Residue
J	GLN346
J	LYS489

site_id	AP4
Number of Residues	5
Details	binding site for residue EDO J 2106

Chain	Residue
J	LYS667
J	SER671
J	THR697
J	LEU698
J	GLY699

site_id	AP5
Number of Residues	1
Details	binding site for residue NA J 2107

Chain	Residue
J	ASP913

site_id	AP6
Number of Residues	5
Details	binding site for residue NA J 2108

Chain	Residue
J	ILE821
J	ALA822
J	CYS824
J	ALA1060
J	THR1063

site_id	AP7
Number of Residues	18
Details	binding site for residue FMN K 2101

Chain	Residue
K	PRO595
K	GLY596
K	MET597
K	THR598
K	ASN650
K	ILE652
K	GLY682
K	LYS706
K	THR733
K	GLY737
K	GLY738
K	GLY739
K	SER769
K	GLY770
K	GLY802
K	SER803
K	LEU1054
K	ALA1059

site_id	AP8
Number of Residues	1
Details	binding site for residue NA K 2102

Chain	Residue
K	ASP913

site_id	AP9
Number of Residues	5
Details	binding site for residue NA K 2103

Chain	Residue
K	ILE821
K	ALA822
K	CYS824
K	ALA1060
K	THR1063

site_id	AQ1
Number of Residues	17
Details	binding site for residue FMN L 2101

Chain	Residue
L	PRO595
L	GLY596
L	MET597
L	THR598
L	ASN650
L	GLY682
L	LYS706
L	THR733
L	GLY737
L	GLY738
L	GLY739
L	SER769
L	GLY770
L	GLY802
L	SER803
L	LEU1054
L	ALA1059

site_id	AQ2
Number of Residues	1
Details	binding site for residue NA L 2102

Chain	Residue
L	ASP913

site_id	AQ3
Number of Residues	5
Details	binding site for residue NA L 2103

Chain	Residue
L	ILE821
L	ALA822
L	CYS824
L	ALA1060
L	THR1063

site_id	AQ4
Number of Residues	18
Details	binding site for Di-peptide PNS D 1901 and SER D 180

Chain	Residue
C	CYS1305
C	MET1346
C	SER1417
C	PRO1419
C	ALA1420
C	HIS1542
C	THR1544
C	THR1546
C	ALA1548
C	ASN1549
C	PHE1644
C	PHE1646
D	GLY178
D	LYS179
D	THR181
D	VAL182
D	GLN183
D	ASN184

site_id	AQ5
Number of Residues	17
Details	binding site for Di-peptide PNS E 1901 and SER E 180

Chain	Residue
B	CYS1305
B	MET1346
B	SER1417
B	PRO1419
B	ALA1420
B	HIS1542
B	THR1544
B	THR1546
B	ASN1549
B	PHE1644
B	PHE1646
E	GLY178
E	LYS179
E	THR181
E	VAL182
E	GLN183
E	ASN184

site_id	AQ6
Number of Residues	15
Details	binding site for Di-peptide PNS F 1901 and SER F 180

Chain	Residue
A	MET1346
A	SER1417
A	PRO1419
A	ALA1420
A	THR1544
A	THR1546
A	ALA1548
A	ASN1549
A	PHE1644
F	GLY178
F	LYS179
F	THR181
F	VAL182
F	GLN183
F	ASN184

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. LVGGKSTVQNEILGDL

Chain	Residue	Details
A	LEU175-LEU190

site_id	PS00606
Number of Residues	17
Details	KS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATSveSV

Chain	Residue	Details
A	GLY1296-VAL1312

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	450
Details	Domain: {"description":"Carrier","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	3204
Details	Domain: {"description":"Ketosynthase family 3 (KS3)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1194
Details	Region: {"description":"Beta-ketoacyl reductase"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	18
Details	Active site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	132
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19679086","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15665377","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	6
Details	Modified residue: {"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17431182","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	24
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	750
Details	Domain: {"description":"MaoC-like"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2328
Details	Region: {"description":"Enoyl reductase"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2892
Details	Region: {"description":"Dehydratase"}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	436
Details	Region: {"description":"Malonyl/palmitoyl transferase"}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	6
Details	Active site: {"description":"For acetyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	6
Details	Active site: {"description":"For malonyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)