6QGQ

Crystal structure of APT1 C2S mutant bound to palmitic acid.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002084	biological_process	protein depalmitoylation
A	0004620	molecular_function	phospholipase activity
A	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0008474	molecular_function	palmitoyl-(protein) hydrolase activity
A	0015908	biological_process	fatty acid transport
A	0016298	molecular_function	lipase activity
A	0016787	molecular_function	hydrolase activity
A	0031965	cellular_component	nuclear membrane
A	0042997	biological_process	negative regulation of Golgi to plasma membrane protein transport
A	0070062	cellular_component	extracellular exosome
A	1905336	biological_process	negative regulation of aggrephagy
B	0002084	biological_process	protein depalmitoylation
B	0004620	molecular_function	phospholipase activity
B	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005783	cellular_component	endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0008474	molecular_function	palmitoyl-(protein) hydrolase activity
B	0015908	biological_process	fatty acid transport
B	0016298	molecular_function	lipase activity
B	0016787	molecular_function	hydrolase activity
B	0031965	cellular_component	nuclear membrane
B	0042997	biological_process	negative regulation of Golgi to plasma membrane protein transport
B	0070062	cellular_component	extracellular exosome
B	1905336	biological_process	negative regulation of aggrephagy
C	0002084	biological_process	protein depalmitoylation
C	0004620	molecular_function	phospholipase activity
C	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005783	cellular_component	endoplasmic reticulum
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0008474	molecular_function	palmitoyl-(protein) hydrolase activity
C	0015908	biological_process	fatty acid transport
C	0016298	molecular_function	lipase activity
C	0016787	molecular_function	hydrolase activity
C	0031965	cellular_component	nuclear membrane
C	0042997	biological_process	negative regulation of Golgi to plasma membrane protein transport
C	0070062	cellular_component	extracellular exosome
C	1905336	biological_process	negative regulation of aggrephagy
D	0002084	biological_process	protein depalmitoylation
D	0004620	molecular_function	phospholipase activity
D	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005783	cellular_component	endoplasmic reticulum
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0008474	molecular_function	palmitoyl-(protein) hydrolase activity
D	0015908	biological_process	fatty acid transport
D	0016298	molecular_function	lipase activity
D	0016787	molecular_function	hydrolase activity
D	0031965	cellular_component	nuclear membrane
D	0042997	biological_process	negative regulation of Golgi to plasma membrane protein transport
D	0070062	cellular_component	extracellular exosome
D	1905336	biological_process	negative regulation of aggrephagy

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue GOL A 301

Chain	Residue
A	TRP37
B	MET65

---

site_id	AC2
Number of Residues	3
Details	binding site for residue GOL A 302

Chain	Residue
A	MET65
A	HOH403
B	GLY36

---

site_id	AC3
Number of Residues	9
Details	binding site for residue PLM B 401

Chain	Residue
B	TRP145
B	ARG149
B	PHE181
B	THR185
B	HOH505
B	LEU30
B	LEU78
B	SER119
B	GLN120

---

site_id	AC4
Number of Residues	5
Details	binding site for residue GOL C 601

Chain	Residue
C	ASP32
C	GLY36
C	TRP37
C	SER210
C	HOH722

---

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL D 301

Chain	Residue
C	MET65
D	ASP32
D	GLY36
D	TRP37
D	SER210
D	HOH402

---

site_id	AC6
Number of Residues	11
Details	binding site for residue PLM D 302

Chain	Residue
D	LEU30
D	ILE75
D	GLY77
D	LEU78
D	SER79
D	SER119
D	GLN120
D	TRP145
D	VAL177
D	PHE181
D	HOH407

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"19439193","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37802024","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"11080636","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P97823","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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