6Q2J

Cryo-EM structure of extracellular dimeric complex of RET/GFRAL/GDF15

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008083	molecular_function	growth factor activity
B	0005576	cellular_component	extracellular region
B	0008083	molecular_function	growth factor activity
C	0038023	molecular_function	signaling receptor activity
D	0038023	molecular_function	signaling receptor activity
E	0005509	molecular_function	calcium ion binding
E	0007156	biological_process	homophilic cell adhesion via plasma membrane adhesion molecules
E	0016020	cellular_component	membrane
F	0005509	molecular_function	calcium ion binding
F	0007156	biological_process	homophilic cell adhesion via plasma membrane adhesion molecules
F	0016020	cellular_component	membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1212
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
E	LEU29-ARG635
D	ASN67
D	ASN103
D	ASN116
F	LEU29-ARG635
C	ASN62
C	ASN67
C	ASN103
C	ASN116
D	ASN23
D	ASN50
D	ASN62

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Breakpoint for translocation to form the TRIM27/RET oncogene

Chain	Residue	Details
E	ARG587
F	ARG587

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site_id	SWS_FT_FI3
Number of Residues	22
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
E	ASN98
E	ASN468
E	ASN554
F	ASN98
F	ASN199
F	ASN336
F	ASN343
F	ASN361
F	ASN367
F	ASN377
F	ASN394
E	ASN199
F	ASN448
F	ASN468
F	ASN554
E	ASN336
E	ASN343
E	ASN361
E	ASN367
E	ASN377
E	ASN394
E	ASN448

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20473317

Chain	Residue	Details
E	ASN151
F	ASN151

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