6Q0V
Structure of DDB1-DDA1-DCAF15 complex bound to tasisulam and RBM39
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003676 | molecular_function | nucleic acid binding |
A | 0005634 | cellular_component | nucleus |
B | 0016567 | biological_process | protein ubiquitination |
C | 0016567 | biological_process | protein ubiquitination |
D | 0003676 | molecular_function | nucleic acid binding |
D | 0003723 | molecular_function | RNA binding |
D | 0005634 | cellular_component | nucleus |
D | 0006397 | biological_process | mRNA processing |
E | 0000209 | biological_process | protein polyubiquitination |
E | 0005515 | molecular_function | protein binding |
E | 0005654 | cellular_component | nucleoplasm |
E | 0016567 | biological_process | protein ubiquitination |
E | 0032434 | biological_process | regulation of proteasomal ubiquitin-dependent protein catabolic process |
E | 0032436 | biological_process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
E | 0080008 | cellular_component | Cul4-RING E3 ubiquitin ligase complex |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | binding site for residue P7M B 301 |
Chain | Residue |
B | THR230 |
D | ASP264 |
D | MET265 |
D | HOH401 |
B | PHE231 |
B | GLN232 |
B | PRO233 |
B | ALA234 |
B | PHE235 |
C | VAL556 |
C | VAL559 |
C | LEU563 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue ZN B 302 |
Chain | Residue |
B | CYS193 |
B | CYS196 |
B | CYS211 |
B | HIS214 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:22814378 |
Chain | Residue | Details |
E | ALA2 | |
B | CYS196 | |
B | CYS211 | |
B | HIS214 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
E | SER33 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
E | SER95 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
B | SER50 |