6PEG

MIF with a allosteric inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0001516	biological_process	prostaglandin biosynthetic process
D	0001819	biological_process	positive regulation of cytokine production
D	0001934	biological_process	positive regulation of protein phosphorylation
D	0002020	molecular_function	protease binding
D	0002906	biological_process	negative regulation of mature B cell apoptotic process
D	0004167	molecular_function	dopachrome isomerase activity
D	0005125	molecular_function	cytokine activity
D	0005126	molecular_function	cytokine receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006954	biological_process	inflammatory response
D	0007166	biological_process	cell surface receptor signaling pathway
D	0008284	biological_process	positive regulation of cell population proliferation
D	0009986	cellular_component	cell surface
D	0010629	biological_process	negative regulation of gene expression
D	0010739	biological_process	positive regulation of protein kinase A signaling
D	0010760	biological_process	negative regulation of macrophage chemotaxis
D	0016853	molecular_function	isomerase activity
D	0019752	biological_process	carboxylic acid metabolic process
D	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
D	0030336	biological_process	negative regulation of cell migration
D	0030890	biological_process	positive regulation of B cell proliferation
D	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
D	0031982	cellular_component	vesicle
D	0032760	biological_process	positive regulation of tumor necrosis factor production
D	0033033	biological_process	negative regulation of myeloid cell apoptotic process
D	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
D	0034774	cellular_component	secretory granule lumen
D	0042056	molecular_function	chemoattractant activity
D	0042127	biological_process	regulation of cell population proliferation
D	0042327	biological_process	positive regulation of phosphorylation
D	0042802	molecular_function	identical protein binding
D	0043030	biological_process	regulation of macrophage activation
D	0043066	biological_process	negative regulation of apoptotic process
D	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
D	0045087	biological_process	innate immune response
D	0048146	biological_process	positive regulation of fibroblast proliferation
D	0050178	molecular_function	phenylpyruvate tautomerase activity
D	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
D	0050918	biological_process	positive chemotaxis
D	0051248	biological_process	negative regulation of protein metabolic process
D	0061078	biological_process	positive regulation of prostaglandin secretion involved in immune response
D	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
D	0070062	cellular_component	extracellular exosome
D	0070207	biological_process	protein homotrimerization
D	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
D	0090238	biological_process	positive regulation of arachidonic acid secretion
D	0090398	biological_process	cellular senescence
D	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
D	1904813	cellular_component	ficolin-1-rich granule lumen
D	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
D	2000773	biological_process	negative regulation of cellular senescence
E	0001516	biological_process	prostaglandin biosynthetic process
E	0001819	biological_process	positive regulation of cytokine production
E	0001934	biological_process	positive regulation of protein phosphorylation
E	0002020	molecular_function	protease binding
E	0002906	biological_process	negative regulation of mature B cell apoptotic process
E	0004167	molecular_function	dopachrome isomerase activity
E	0005125	molecular_function	cytokine activity
E	0005126	molecular_function	cytokine receptor binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006954	biological_process	inflammatory response
E	0007166	biological_process	cell surface receptor signaling pathway
E	0008284	biological_process	positive regulation of cell population proliferation
E	0009986	cellular_component	cell surface
E	0010629	biological_process	negative regulation of gene expression
E	0010739	biological_process	positive regulation of protein kinase A signaling
E	0010760	biological_process	negative regulation of macrophage chemotaxis
E	0016853	molecular_function	isomerase activity
E	0019752	biological_process	carboxylic acid metabolic process
E	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
E	0030336	biological_process	negative regulation of cell migration
E	0030890	biological_process	positive regulation of B cell proliferation
E	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
E	0031982	cellular_component	vesicle
E	0032760	biological_process	positive regulation of tumor necrosis factor production
E	0033033	biological_process	negative regulation of myeloid cell apoptotic process
E	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
E	0034774	cellular_component	secretory granule lumen
E	0042056	molecular_function	chemoattractant activity
E	0042127	biological_process	regulation of cell population proliferation
E	0042327	biological_process	positive regulation of phosphorylation
E	0042802	molecular_function	identical protein binding
E	0043030	biological_process	regulation of macrophage activation
E	0043066	biological_process	negative regulation of apoptotic process
E	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
E	0045087	biological_process	innate immune response
E	0048146	biological_process	positive regulation of fibroblast proliferation
E	0050178	molecular_function	phenylpyruvate tautomerase activity
E	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
E	0050918	biological_process	positive chemotaxis
E	0051248	biological_process	negative regulation of protein metabolic process
E	0061078	biological_process	positive regulation of prostaglandin secretion involved in immune response
E	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
E	0070062	cellular_component	extracellular exosome
E	0070207	biological_process	protein homotrimerization
E	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
E	0090238	biological_process	positive regulation of arachidonic acid secretion
E	0090398	biological_process	cellular senescence
E	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
E	1904813	cellular_component	ficolin-1-rich granule lumen
E	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
E	2000773	biological_process	negative regulation of cellular senescence
F	0001516	biological_process	prostaglandin biosynthetic process
F	0001819	biological_process	positive regulation of cytokine production
F	0001934	biological_process	positive regulation of protein phosphorylation
F	0002020	molecular_function	protease binding
F	0002906	biological_process	negative regulation of mature B cell apoptotic process
F	0004167	molecular_function	dopachrome isomerase activity
F	0005125	molecular_function	cytokine activity
F	0005126	molecular_function	cytokine receptor binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006954	biological_process	inflammatory response
F	0007166	biological_process	cell surface receptor signaling pathway
F	0008284	biological_process	positive regulation of cell population proliferation
F	0009986	cellular_component	cell surface
F	0010629	biological_process	negative regulation of gene expression
F	0010739	biological_process	positive regulation of protein kinase A signaling
F	0010760	biological_process	negative regulation of macrophage chemotaxis
F	0016853	molecular_function	isomerase activity
F	0019752	biological_process	carboxylic acid metabolic process
F	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
F	0030336	biological_process	negative regulation of cell migration
F	0030890	biological_process	positive regulation of B cell proliferation
F	0031666	biological_process	positive regulation of lipopolysaccharide-mediated signaling pathway
F	0031982	cellular_component	vesicle
F	0032760	biological_process	positive regulation of tumor necrosis factor production
F	0033033	biological_process	negative regulation of myeloid cell apoptotic process
F	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
F	0034774	cellular_component	secretory granule lumen
F	0042056	molecular_function	chemoattractant activity
F	0042127	biological_process	regulation of cell population proliferation
F	0042327	biological_process	positive regulation of phosphorylation
F	0042802	molecular_function	identical protein binding
F	0043030	biological_process	regulation of macrophage activation
F	0043066	biological_process	negative regulation of apoptotic process
F	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
F	0045087	biological_process	innate immune response
F	0048146	biological_process	positive regulation of fibroblast proliferation
F	0050178	molecular_function	phenylpyruvate tautomerase activity
F	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
F	0050918	biological_process	positive chemotaxis
F	0051248	biological_process	negative regulation of protein metabolic process
F	0061078	biological_process	positive regulation of prostaglandin secretion involved in immune response
F	0061081	biological_process	positive regulation of myeloid leukocyte cytokine production involved in immune response
F	0070062	cellular_component	extracellular exosome
F	0070207	biological_process	protein homotrimerization
F	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
F	0090238	biological_process	positive regulation of arachidonic acid secretion
F	0090398	biological_process	cellular senescence
F	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
F	1904813	cellular_component	ficolin-1-rich granule lumen
F	2000343	biological_process	positive regulation of chemokine (C-X-C motif) ligand 2 production
F	2000773	biological_process	negative regulation of cellular senescence

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ACT D 201

Chain	Residue
D	GLN35
D	TYR36
D	HOH305
E	TYR95

---

site_id	AC2
Number of Residues	4
Details	binding site for residue GOL D 202

Chain	Residue
D	LYS66
D	HOH309
D	HOH393
E	ARG86

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ACT D 203

Chain	Residue
D	ILE64
E	TYR95
E	HOH380
D	PRO1

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 D 204

Chain	Residue
D	GLY68
D	GLY69
D	ALA70
D	GLN71
D	HOH330

---

site_id	AC5
Number of Residues	19
Details	binding site for residue 4FQ E 201

Chain	Residue
D	GLY51
D	SER52
D	SER53
D	GLU54
D	HOH327
D	HOH369
E	LYS32
E	GLN35
E	TYR36
E	ILE64
E	ALA103
E	TRP108
E	PHE113
E	PO4204
E	HOH303
E	HOH306
E	HOH329
E	HOH439
F	TYR95

---

site_id	AC6
Number of Residues	6
Details	binding site for residue SO4 E 202

Chain	Residue
D	HIS62
D	TYR99
E	HIS62
E	TYR99
F	HIS62
F	TYR99

---

site_id	AC7
Number of Residues	8
Details	binding site for residue PO4 E 203

Chain	Residue
E	GLY68
E	GLY69
E	ALA70
E	GLN71
E	HOH304
E	HOH320
E	HOH325
E	HOH391

---

site_id	AC8
Number of Residues	5
Details	binding site for residue PO4 E 204

Chain	Residue
E	LYS32
E	TYR36
E	ILE64
E	4FQ201
F	TYR95

---

site_id	AC9
Number of Residues	8
Details	binding site for residue GOL F 201

Chain	Residue
D	TYR95
F	PRO1
F	LYS32
F	SER63
F	ILE64
F	HOH325
F	HOH326
F	HOH338

---

site_id	AD1
Number of Residues	6
Details	binding site for residue ACT F 202

Chain	Residue
E	PRO1
E	MET2
E	HIS62
E	ILE64
F	TYR95
F	ASN97

---

site_id	AD2
Number of Residues	3
Details	binding site for residue ACT F 203

Chain	Residue
D	GLU85
D	ARG86
F	LYS66

---

site_id	AD3
Number of Residues	6
Details	binding site for residue SO4 F 204

Chain	Residue
F	GLY68
F	GLY69
F	ALA70
F	GLN71
F	HOH308
F	HOH322

---

Functional Information from PROSITE/UniProt

site_id	PS01158
Number of Residues	15
Details	MIF Macrophage migration inhibitory factor family signature. EPCAlcsLhSIGkIG

Chain	Residue	Details
D	GLU54-GLY68

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Proton acceptor; via imino nitrogen => ECO:0000250|UniProtKB:P34884

Chain	Residue	Details
D	PRO1
E	PRO1
F	PRO1

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677

Chain	Residue	Details
F	LYS32
F	ILE64
F	ASN97
D	LYS32
D	ILE64
D	ASN97
E	LYS32
E	ILE64
E	ASN97

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P34884

Chain	Residue	Details
F	LYS77
D	LYS77
E	LYS77

---