Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004713 | molecular_function | protein tyrosine kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006468 | biological_process | protein phosphorylation |
B | 0004672 | molecular_function | protein kinase activity |
B | 0004713 | molecular_function | protein tyrosine kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006468 | biological_process | protein phosphorylation |
C | 0004672 | molecular_function | protein kinase activity |
C | 0004713 | molecular_function | protein tyrosine kinase activity |
C | 0005524 | molecular_function | ATP binding |
C | 0006468 | biological_process | protein phosphorylation |
D | 0004672 | molecular_function | protein kinase activity |
D | 0004713 | molecular_function | protein tyrosine kinase activity |
D | 0005524 | molecular_function | ATP binding |
D | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 29 |
Details | binding site for residue ANP A 2001 |
Chain | Residue |
A | LEU718 |
A | GLN791 |
A | MET793 |
A | CYS797 |
A | ASP837 |
A | ARG841 |
A | ASN842 |
A | LEU844 |
A | ASP855 |
A | MG2003 |
A | MG2004 |
A | GLY719 |
A | HOH2101 |
A | HOH2122 |
A | HOH2141 |
A | HOH2181 |
A | HOH2189 |
A | HOH2197 |
A | HOH2198 |
A | HOH2201 |
A | HOH2232 |
A | HOH2260 |
A | SER720 |
A | GLY721 |
A | ALA722 |
A | VAL726 |
A | ALA743 |
A | LYS745 |
A | MET790 |
site_id | AC2 |
Number of Residues | 11 |
Details | binding site for residue O57 A 2002 |
Chain | Residue |
A | ALA743 |
A | LYS745 |
A | MET766 |
A | CYS775 |
A | LEU777 |
A | LEU788 |
A | MET790 |
A | ASP855 |
A | PHE856 |
A | LEU858 |
A | LEU861 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue MG A 2003 |
Chain | Residue |
A | ALA722 |
A | PHE723 |
A | GLY724 |
A | LYS745 |
A | ANP2001 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue MG A 2004 |
Chain | Residue |
A | ASN842 |
A | ASP855 |
A | ANP2001 |
A | HOH2181 |
site_id | AC5 |
Number of Residues | 19 |
Details | binding site for residue AMP B 2001 |
Chain | Residue |
B | SER720 |
B | GLY721 |
B | VAL726 |
B | ALA743 |
B | LYS745 |
B | MET790 |
B | GLN791 |
B | MET793 |
B | CYS797 |
B | ARG841 |
B | LEU844 |
B | ASP855 |
B | MG2003 |
B | HOH2105 |
B | HOH2155 |
B | HOH2182 |
B | HOH2233 |
B | HOH2259 |
B | HOH2286 |
site_id | AC6 |
Number of Residues | 10 |
Details | binding site for residue O57 B 2002 |
Chain | Residue |
B | LYS745 |
B | CYS775 |
B | LEU777 |
B | LEU788 |
B | MET790 |
B | THR854 |
B | ASP855 |
B | PHE856 |
B | LEU858 |
B | LEU861 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue MG B 2003 |
Chain | Residue |
B | GLY721 |
B | ALA722 |
B | PHE723 |
B | GLY724 |
B | LYS745 |
B | AMP2001 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue EDO B 2004 |
Chain | Residue |
B | TYR801 |
B | ASN808 |
B | TYR813 |
B | HIS988 |
B | HOH2137 |
site_id | AC9 |
Number of Residues | 3 |
Details | binding site for residue EDO B 2005 |
Chain | Residue |
B | GLN935 |
B | CYS939 |
B | HOH2262 |
site_id | AD1 |
Number of Residues | 21 |
Details | binding site for residue AMP C 2001 |
Chain | Residue |
C | GLN791 |
C | MET793 |
C | CYS797 |
C | ARG841 |
C | LEU844 |
C | ASP855 |
C | MG2003 |
C | HOH2117 |
C | HOH2139 |
C | HOH2168 |
C | HOH2204 |
C | HOH2233 |
C | HOH2241 |
C | HOH2277 |
C | LEU718 |
C | SER720 |
C | GLY721 |
C | VAL726 |
C | ALA743 |
C | LYS745 |
C | MET790 |
site_id | AD2 |
Number of Residues | 13 |
Details | binding site for residue O57 C 2002 |
Chain | Residue |
C | ALA743 |
C | LYS745 |
C | MET766 |
C | CYS775 |
C | ARG776 |
C | LEU777 |
C | LEU788 |
C | MET790 |
C | THR854 |
C | ASP855 |
C | PHE856 |
C | LEU858 |
C | LEU861 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue MG C 2003 |
Chain | Residue |
C | GLY721 |
C | ALA722 |
C | PHE723 |
C | GLY724 |
C | LYS745 |
C | AMP2001 |
site_id | AD4 |
Number of Residues | 3 |
Details | binding site for residue EDO C 2004 |
Chain | Residue |
C | SER924 |
C | HOH2131 |
C | HOH2178 |
site_id | AD5 |
Number of Residues | 2 |
Details | binding site for residue EDO C 2005 |
Chain | Residue |
C | TRP905 |
C | SER912 |
site_id | AD6 |
Number of Residues | 6 |
Details | binding site for residue EDO C 2006 |
Chain | Residue |
C | TYR801 |
C | GLU804 |
C | HIS805 |
C | HOH2103 |
C | HOH2126 |
D | VAL738 |
site_id | AD7 |
Number of Residues | 5 |
Details | binding site for residue EDO C 2007 |
Chain | Residue |
A | LYS716 |
C | ASN771 |
C | LYS823 |
C | ASP1008 |
C | HOH2151 |
site_id | AD8 |
Number of Residues | 4 |
Details | binding site for residue EDO C 2008 |
Chain | Residue |
B | LYS929 |
B | GLY930 |
B | GLU931 |
C | ASP916 |
site_id | AD9 |
Number of Residues | 18 |
Details | binding site for residue AMP D 2001 |
Chain | Residue |
D | LEU718 |
D | SER720 |
D | GLY721 |
D | VAL726 |
D | ALA743 |
D | LYS745 |
D | MET790 |
D | GLN791 |
D | MET793 |
D | ARG841 |
D | LEU844 |
D | ASP855 |
D | MG2003 |
D | HOH2114 |
D | HOH2115 |
D | HOH2119 |
D | HOH2201 |
D | HOH2226 |
site_id | AE1 |
Number of Residues | 11 |
Details | binding site for residue O57 D 2002 |
Chain | Residue |
D | ALA743 |
D | LYS745 |
D | MET766 |
D | CYS775 |
D | LEU777 |
D | LEU788 |
D | MET790 |
D | ASP855 |
D | PHE856 |
D | LEU858 |
D | LEU861 |
site_id | AE2 |
Number of Residues | 5 |
Details | binding site for residue MG D 2003 |
Chain | Residue |
D | GLY721 |
D | PHE723 |
D | GLY724 |
D | LYS745 |
D | AMP2001 |
site_id | AE3 |
Number of Residues | 8 |
Details | binding site for residue EDO D 2004 |
Chain | Residue |
C | ASP994 |
D | ARG705 |
D | TRP731 |
D | PRO733 |
D | GLU734 |
D | HOH2109 |
D | HOH2136 |
D | HOH2137 |
site_id | AE4 |
Number of Residues | 5 |
Details | binding site for residue EDO D 2005 |
Chain | Residue |
D | ASN826 |
D | ARG962 |
D | ILE965 |
D | HOH2105 |
D | HOH2228 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 28 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGAFGTVYkGlwipegekvkip......VAIK |
Chain | Residue | Details |
A | LEU718-LYS745 | |
site_id | PS00109 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LVHrDLAARNVLV |
Chain | Residue | Details |
A | LEU833-VAL845 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ASP837 | |
B | ASP837 | |
C | ASP837 | |
D | ASP837 | |
Chain | Residue | Details |
A | LEU718 | |
B | LEU718 | |
C | LEU718 | |
D | LEU718 | |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:3VJO, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41 |
Chain | Residue | Details |
A | LYS745 | |
B | LYS745 | |
C | LYS745 | |
D | LYS745 | |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:2ITV, ECO:0007744|PDB:2ITX, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:3VJO, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIX, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41 |
Chain | Residue | Details |
A | MET790 | |
B | MET790 | |
C | MET790 | |
D | MET790 | |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:2ITV, ECO:0007744|PDB:2ITX, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIX, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41 |
Chain | Residue | Details |
A | ASP855 | |
B | ASP855 | |
C | ASP855 | |
D | ASP855 | |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | SITE: Important for interaction with PIK3C2B |
Chain | Residue | Details |
A | TYR1016 | |
B | TYR1016 | |
C | TYR1016 | |
D | TYR1016 | |
Chain | Residue | Details |
A | LYS745 | |
B | LYS745 | |
C | LYS745 | |
D | LYS745 | |
Chain | Residue | Details |
A | TYR869 | |
B | TYR869 | |
C | TYR869 | |
D | TYR869 | |
Chain | Residue | Details |
A | SER991 | |
B | SER991 | |
C | SER991 | |
D | SER991 | |
Chain | Residue | Details |
A | SER995 | |
B | SER995 | |
C | SER995 | |
D | SER995 | |
Chain | Residue | Details |
A | TYR998 | |
B | TYR998 | |
C | TYR998 | |
D | TYR998 | |
Chain | Residue | Details |
B | TYR1016 | |
A | TYR1016 | |
C | TYR1016 | |
D | TYR1016 | |
Chain | Residue | Details |
A | LYS716 | |
A | LYS737 | |
C | LYS716 | |
D | LYS867 | |
A | LYS754 | |
A | LYS867 | |
B | LYS716 | |
B | LYS737 | |
B | LYS754 | |
B | LYS867 | |
C | LYS737 | |
C | LYS754 | |
C | LYS867 | |
D | LYS716 | |
D | LYS737 | |
D | LYS754 | |
site_id | SWS_FT_FI14 |
Number of Residues | 12 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144 |
Chain | Residue | Details |
A | LYS929 | |
A | LYS970 | |
B | LYS929 | |
B | LYS970 | |
C | LYS929 | |
C | LYS970 | |
D | LYS929 | |
D | LYS970 | |
site_id | SWS_FT_FI15 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:33996800 |
Chain | Residue | Details |
A | LYS757 | |
A | LYS960 | |
B | LYS757 | |
B | LYS960 | |
C | LYS757 | |
C | LYS960 | |
D | LYS757 | |
D | LYS960 | |