Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6OX4

A SETD3 Mutant (N255A) in Complex with an Actin Peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000785	cellular_component	chromatin
A	0003713	molecular_function	transcription coactivator activity
A	0003779	molecular_function	actin binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0006338	biological_process	chromatin remodeling
A	0008168	molecular_function	methyltransferase activity
A	0016279	molecular_function	protein-lysine N-methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0018021	biological_process	peptidyl-histidine methylation
A	0018023	biological_process	peptidyl-lysine trimethylation
A	0018064	molecular_function	protein-L-histidine N-tele-methyltransferase activity
A	0030047	biological_process	actin modification
A	0032259	biological_process	methylation
A	0042800	molecular_function	histone H3K4 methyltransferase activity
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046975	molecular_function	histone H3K36 methyltransferase activity
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0070472	biological_process	regulation of uterine smooth muscle contraction
B	0000785	cellular_component	chromatin
B	0003713	molecular_function	transcription coactivator activity
B	0003779	molecular_function	actin binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0006338	biological_process	chromatin remodeling
B	0008168	molecular_function	methyltransferase activity
B	0016279	molecular_function	protein-lysine N-methyltransferase activity
B	0016740	molecular_function	transferase activity
B	0018021	biological_process	peptidyl-histidine methylation
B	0018023	biological_process	peptidyl-lysine trimethylation
B	0018064	molecular_function	protein-L-histidine N-tele-methyltransferase activity
B	0030047	biological_process	actin modification
B	0032259	biological_process	methylation
B	0042800	molecular_function	histone H3K4 methyltransferase activity
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046975	molecular_function	histone H3K36 methyltransferase activity
B	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
B	0070472	biological_process	regulation of uterine smooth muscle contraction

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue EDO Y 101

Chain	Residue
A	ASN153
Y	THR77
Y	ASN78

site_id	AC2
Number of Residues	19
Details	binding site for residue SAH A 601

Chain	Residue
A	MET275
A	CYS276
A	ASN277
A	HIS278
A	TYR312
A	SER324
A	PHE326
A	PHE328
A	GOL619
A	HOH751
A	HOH803
A	HOH804
A	HOH815
A	ARG74
A	GLU103
A	PHE105
A	PRO179
A	ARG253
A	ASP274

site_id	AC3
Number of Residues	2
Details	binding site for residue EDO A 602

Chain	Residue
A	EDO610
A	HOH746

site_id	AC4
Number of Residues	9
Details	binding site for residue EDO A 603

Chain	Residue
A	SER316
A	ASN317
A	ALA318
A	ASP334
A	ARG335
A	VAL336
A	LEU466
A	GLU470
A	EDO606

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 604

Chain	Residue
A	ASP204
A	ALA318
A	GLU319
A	EDO606
A	HOH704

site_id	AC6
Number of Residues	2
Details	binding site for residue EDO A 605

Chain	Residue
A	ALA378
A	ILE407

site_id	AC7
Number of Residues	6
Details	binding site for residue EDO A 606

Chain	Residue
A	SER316
A	ALA318
A	GLU319
A	ARG335
A	EDO603
A	EDO604

site_id	AC8
Number of Residues	4
Details	binding site for residue EDO A 607

Chain	Residue
A	LEU451
A	HIS454
A	LEU456
A	LYS461

site_id	AC9
Number of Residues	6
Details	binding site for residue EDO A 608

Chain	Residue
A	GLN256
A	ILE257
A	PRO258
A	VAL265
Y	TYR69
Y	PRO70

site_id	AD1
Number of Residues	2
Details	binding site for residue EDO A 609

Chain	Residue
A	ASP334
A	GLU472

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO A 610

Chain	Residue
A	LYS448
A	GLU472
A	EDO602
A	HOH746
A	HOH862

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO A 611

Chain	Residue
A	ARG60
A	LYS61
A	GLN63
A	HOH716

site_id	AD4
Number of Residues	5
Details	binding site for residue EDO A 612

Chain	Residue
A	ILE24
A	GLN63
A	TYR220
A	SER237
A	PHE238

site_id	AD5
Number of Residues	1
Details	binding site for residue EDO A 613

Chain	Residue
A	SER364

site_id	AD6
Number of Residues	2
Details	binding site for residue EDO A 614

Chain	Residue
A	ARG53
A	GLU190

site_id	AD7
Number of Residues	3
Details	binding site for residue EDO A 615

Chain	Residue
A	PHE327
A	VAL458
A	LYS465

site_id	AD8
Number of Residues	6
Details	binding site for residue EDO A 616

Chain	Residue
A	LEU399
A	GLY400
A	ASP401
A	SER402
A	ALA403
A	ARG406

site_id	AD9
Number of Residues	1
Details	binding site for residue EDO A 617

Chain	Residue
A	ASP401

site_id	AE1
Number of Residues	3
Details	binding site for residue GOL A 618

Chain	Residue
A	LYS125
A	TRP171
A	HOH750

site_id	AE2
Number of Residues	6
Details	binding site for residue GOL A 619

Chain	Residue
A	GLU103
A	GLU181
A	TYR182
A	SAH601
A	HOH783
A	HOH823

site_id	AE3
Number of Residues	4
Details	binding site for residue GOL A 620

Chain	Residue
A	ILE338
A	LYS339
A	ARG432
A	HOH725

site_id	AE4
Number of Residues	4
Details	binding site for residue ACT A 621

Chain	Residue
A	ALA368
A	SER377
A	HOH764
A	PHE367

site_id	AE5
Number of Residues	5
Details	binding site for residue ACT A 622

Chain	Residue
A	GLN197
A	SER198
A	PHE206
A	HOH822
A	HOH844

site_id	AE6
Number of Residues	19
Details	binding site for residue SAH B 601

Chain	Residue
B	ARG74
B	GLU102
B	GLU103
B	PHE105
B	PRO179
B	ARG253
B	ASP274
B	MET275
B	CYS276
B	ASN277
B	HIS278
B	TYR312
B	SER324
B	PHE326
B	HOH779
B	HOH799
B	HOH802
B	HOH815
B	HOH818

site_id	AE7
Number of Residues	1
Details	binding site for residue EDO B 602

Chain	Residue
B	ILE407

site_id	AE8
Number of Residues	1
Details	binding site for residue EDO B 603

Chain	Residue
B	MET462

site_id	AE9
Number of Residues	3
Details	binding site for residue EDO B 604

Chain	Residue
B	ARG60
B	LYS61
B	GLN63

site_id	AF1
Number of Residues	3
Details	binding site for residue EDO B 605

Chain	Residue
A	LYS101
B	GLU102
B	EDO616

site_id	AF2
Number of Residues	4
Details	binding site for residue EDO B 606

Chain	Residue
B	LEU340
B	GLY341
B	PHE387
B	ARG432

site_id	AF3
Number of Residues	6
Details	binding site for residue EDO B 607

Chain	Residue
A	SER86
B	MET82
B	LYS83
B	SER86
B	HOH722
B	HOH816

site_id	AF4
Number of Residues	6
Details	binding site for residue EDO B 608

Chain	Residue
B	ALA318
B	ASP334
B	ARG335
B	LEU466
B	GLY469
B	GLU470

site_id	AF5
Number of Residues	1
Details	binding site for residue EDO B 609

Chain	Residue
B	HIS333

site_id	AF6
Number of Residues	3
Details	binding site for residue EDO B 610

Chain	Residue
B	GLN63
B	TYR220
B	PHE238

site_id	AF7
Number of Residues	5
Details	binding site for residue EDO B 611

Chain	Residue
A	ASP71
B	LYS64
B	GLY65
B	LEU66
B	THR69

site_id	AF8
Number of Residues	4
Details	binding site for residue EDO B 612

Chain	Residue
B	HIS397
B	ARG406
B	THR409
B	PHE415

site_id	AF9
Number of Residues	7
Details	binding site for residue EDO B 613

Chain	Residue
A	LYS73
B	ARG60
B	TYR187
B	ARG244
B	HOH711
B	HOH739
B	HOH757

site_id	AG1
Number of Residues	2
Details	binding site for residue EDO B 614

Chain	Residue
B	TRP121
B	ARG293

site_id	AG2
Number of Residues	1
Details	binding site for residue EDO B 615

Chain	Residue
B	SER364

site_id	AG3
Number of Residues	4
Details	binding site for residue EDO B 616

Chain	Residue
B	ASP183
B	ARG459
B	EDO605
B	HOH809

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"30526847","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30626964","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30785395","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31388018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32503840","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	440
Details	Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30626964","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30785395","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31388018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31911441","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31993215","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32503840","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2011","submissionDatabase":"PDB data bank","title":"Crystal structure of human SET domain-containing protein 3.","authors":["Zeng H.","Dong A.","Walker J.R.","Loppnau P.","Bountra C.","Weigelt J.","Arrowsmith C.H.","Edwards A.M.","Min J.","Wu H."]}},{"source":"PDB","id":"3SMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ICT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ICV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JAT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WK1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WK2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)