6V62
SETD3 double mutant (N255F/W273A) in Complex with an Actin Peptide with His73 Replaced with Lysine
Summary for 6V62
Entry DOI | 10.2210/pdb6v62/pdb |
Descriptor | Actin, cytoplasmic 1, Actin-histidine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total) |
Functional Keywords | transferase, transferase-structural protein complex, transferase/structural protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 70958.15 |
Authors | Dai, S.,Horton, J.R.,Cheng, X. (deposition date: 2019-12-04, release date: 2020-01-15, Last modification date: 2023-10-11) |
Primary citation | Dai, S.,Horton, J.R.,Wilkinson, A.W.,Gozani, O.,Zhang, X.,Cheng, X. An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation. J.Biol.Chem., 295:2582-2589, 2020 Cited by PubMed: 31911441DOI: 10.1074/jbc.RA119.012319 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.36 Å) |
Structure validation
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