6V62
SETD3 double mutant (N255F/W273A) in Complex with an Actin Peptide with His73 Replaced with Lysine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (Y) | Actin, cytoplasmic 1 | polymer | 23 | 2859.3 | 1 | UniProt (C9JUM1) UniProt (by SIFTS) (P63261) | Homo sapiens | |
| 2 | B (A) | Actin-histidine N-methyltransferase | polymer | 596 | 67404.1 | 1 | UniProt (Q86TU7) Pfam (PF00856) Pfam (PF09273) | Homo sapiens (Human) | SET domain-containing protein 3,hSETD3 |
| 3 | C (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 4 | D, E, F, G, H (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 5 | I, J (Y, A) | water | water | 18.0 | 187 | Chemie (HOH) |
Sequence modifications
Y: 66 - 88 (UniProt: C9JUM1)
A: 0 - 593 (UniProt: Q86TU7)
| PDB | External Database | Details |
|---|---|---|
| Lys 73 | His 73 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Phe 255 | Asn 256 | engineered mutation |
| Ala 273 | Trp 274 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70263.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 694.8 | |
| All* | Total formula weight | 70958.1 |
