6V62
SETD3 double mutant (N255F/W273A) in Complex with an Actin Peptide with His73 Replaced with Lysine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000785 | cellular_component | chromatin |
| A | 0003713 | molecular_function | transcription coactivator activity |
| A | 0003779 | molecular_function | actin binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008170 | molecular_function | N-methyltransferase activity |
| A | 0008276 | molecular_function | protein methyltransferase activity |
| A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| A | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| A | 0018021 | biological_process | peptidyl-histidine methylation |
| A | 0018023 | biological_process | peptidyl-lysine trimethylation |
| A | 0018064 | molecular_function | protein-L-histidine N-tele-methyltransferase activity |
| A | 0030047 | biological_process | actin modification |
| A | 0032259 | biological_process | methylation |
| A | 0042800 | molecular_function | histone H3K4 methyltransferase activity |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0046975 | molecular_function | histone H3K36 methyltransferase activity |
| A | 0051149 | biological_process | positive regulation of muscle cell differentiation |
| A | 0061629 | molecular_function | RNA polymerase II-specific DNA-binding transcription factor binding |
| A | 0070472 | biological_process | regulation of uterine smooth muscle contraction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue SAH A 601 |
| Chain | Residue |
| A | ARG74 |
| A | TYR312 |
| A | SER324 |
| A | PHE326 |
| A | EDO602 |
| A | HOH763 |
| A | HOH797 |
| A | HOH811 |
| Y | LYS73 |
| A | GLU102 |
| A | GLU103 |
| A | PHE105 |
| A | ARG253 |
| A | ASP274 |
| A | MET275 |
| A | ASN277 |
| A | HIS278 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 602 |
| Chain | Residue |
| A | GLU181 |
| A | TYR182 |
| A | SAH601 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 603 |
| Chain | Residue |
| A | ILE24 |
| A | GLN63 |
| A | TYR220 |
| A | SER237 |
| A | PHE238 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 604 |
| Chain | Residue |
| A | ASP334 |
| A | GLU472 |
| A | ILE473 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 605 |
| Chain | Residue |
| A | PHE70 |
| A | ARG164 |
| A | ILE175 |
| A | LEU178 |
| A | SER180 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 606 |
| Chain | Residue |
| A | ASP80 |
| A | LYS83 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Tele-methylhistidine => ECO:0000269|PubMed:30626964, ECO:0000269|Ref.8 |
| Chain | Residue | Details |
| Y | LYS73 | |
| A | GLU103 | |
| A | ARG253 | |
| A | ASP274 | |
| A | SER324 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine => ECO:0000269|PubMed:23673617 |
| Chain | Residue | Details |
| Y | LYS84 |
