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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6OAU

Apo Structure of WT Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D produced in GnTI-deficient HEK293-F cells

Functional Information from GO Data
ChainGOidnamespacecontents
A0001523biological_processretinoid metabolic process
A0004465molecular_functionlipoprotein lipase activity
A0004620molecular_functionphospholipase activity
A0004806molecular_functiontriacylglycerol lipase activity
A0005102molecular_functionsignaling receptor binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005886cellular_componentplasma membrane
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0006633biological_processfatty acid biosynthetic process
A0006641biological_processtriglyceride metabolic process
A0006644biological_processphospholipid metabolic process
A0008201molecular_functionheparin binding
A0008970molecular_functionphospholipase A1 activity
A0009617biological_processresponse to bacterium
A0009749biological_processresponse to glucose
A0009986cellular_componentcell surface
A0010744biological_processpositive regulation of macrophage derived foam cell differentiation
A0010884biological_processpositive regulation of lipid storage
A0010886biological_processpositive regulation of cholesterol storage
A0016020cellular_componentmembrane
A0016042biological_processlipid catabolic process
A0016298molecular_functionlipase activity
A0016787molecular_functionhydrolase activity
A0019433biological_processtriglyceride catabolic process
A0031670biological_processcellular response to nutrient
A0032722biological_processpositive regulation of chemokine production
A0032731biological_processpositive regulation of interleukin-1 beta production
A0032755biological_processpositive regulation of interleukin-6 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0034185molecular_functionapolipoprotein binding
A0034361cellular_componentvery-low-density lipoprotein particle
A0034371biological_processchylomicron remodeling
A0034372biological_processvery-low-density lipoprotein particle remodeling
A0034375biological_processhigh-density lipoprotein particle remodeling
A0034447biological_processvery-low-density lipoprotein particle clearance
A0042627cellular_componentchylomicron
A0042632biological_processcholesterol homeostasis
A0042803molecular_functionprotein homodimerization activity
A0043395molecular_functionheparan sulfate proteoglycan binding
A0043495molecular_functionmembrane-membrane adaptor activity
A0045600biological_processpositive regulation of fat cell differentiation
A0046872molecular_functionmetal ion binding
A0050729biological_processpositive regulation of inflammatory response
A0052689molecular_functioncarboxylic ester hydrolase activity
A0055096biological_processlow-density lipoprotein particle mediated signaling
A0070328biological_processtriglyceride homeostasis
A0071398biological_processcellular response to fatty acid
A0071813molecular_functionlipoprotein particle binding
A1902494cellular_componentcatalytic complex
A1904179biological_processpositive regulation of adipose tissue development
A2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
B0001523biological_processretinoid metabolic process
B0004465molecular_functionlipoprotein lipase activity
B0004620molecular_functionphospholipase activity
B0004806molecular_functiontriacylglycerol lipase activity
B0005102molecular_functionsignaling receptor binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005886cellular_componentplasma membrane
B0006629biological_processlipid metabolic process
B0006631biological_processfatty acid metabolic process
B0006633biological_processfatty acid biosynthetic process
B0006641biological_processtriglyceride metabolic process
B0006644biological_processphospholipid metabolic process
B0008201molecular_functionheparin binding
B0008970molecular_functionphospholipase A1 activity
B0009617biological_processresponse to bacterium
B0009749biological_processresponse to glucose
B0009986cellular_componentcell surface
B0010744biological_processpositive regulation of macrophage derived foam cell differentiation
B0010884biological_processpositive regulation of lipid storage
B0010886biological_processpositive regulation of cholesterol storage
B0016020cellular_componentmembrane
B0016042biological_processlipid catabolic process
B0016298molecular_functionlipase activity
B0016787molecular_functionhydrolase activity
B0019433biological_processtriglyceride catabolic process
B0031670biological_processcellular response to nutrient
B0032722biological_processpositive regulation of chemokine production
B0032731biological_processpositive regulation of interleukin-1 beta production
B0032755biological_processpositive regulation of interleukin-6 production
B0032760biological_processpositive regulation of tumor necrosis factor production
B0034185molecular_functionapolipoprotein binding
B0034361cellular_componentvery-low-density lipoprotein particle
B0034371biological_processchylomicron remodeling
B0034372biological_processvery-low-density lipoprotein particle remodeling
B0034375biological_processhigh-density lipoprotein particle remodeling
B0034447biological_processvery-low-density lipoprotein particle clearance
B0042627cellular_componentchylomicron
B0042632biological_processcholesterol homeostasis
B0042803molecular_functionprotein homodimerization activity
B0043395molecular_functionheparan sulfate proteoglycan binding
B0043495molecular_functionmembrane-membrane adaptor activity
B0045600biological_processpositive regulation of fat cell differentiation
B0046872molecular_functionmetal ion binding
B0050729biological_processpositive regulation of inflammatory response
B0052689molecular_functioncarboxylic ester hydrolase activity
B0055096biological_processlow-density lipoprotein particle mediated signaling
B0070328biological_processtriglyceride homeostasis
B0071398biological_processcellular response to fatty acid
B0071813molecular_functionlipoprotein particle binding
B1902494cellular_componentcatalytic complex
B1904179biological_processpositive regulation of adipose tissue development
B2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
Functional Information from PROSITE/UniProt
site_idPS00120
Number of Residues10
DetailsLIPASE_SER Lipases, serine active site. VHLLGYSLGA
ChainResidueDetails
AVAL153-ALA162
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues42
DetailsRegion: {"description":"Interaction with GPIHBP1","evidences":[{"source":"PubMed","id":"30559189","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues8
DetailsRegion: {"description":"Important for heparin binding","evidences":[{"source":"PubMed","id":"11342582","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues48
DetailsRegion: {"description":"Interaction with GPIHBP1","evidences":[{"source":"PubMed","id":"26725083","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30559189","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"1371284","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30559189","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsActive site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"1371284","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30559189","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30559189","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues6
DetailsModified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"Q06000","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"18780401","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30559189","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6E7K","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"30559189","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6E7K","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues12
DetailsRegion: {"description":"Important for interaction with LPL","evidences":[{"source":"PubMed","id":"26725083","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30559189","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29899144","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30559189","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6E7K","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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