6NAZ

Crystal structure of DIRAS 2/3 chimera in complex with GDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue GOL A 202

Chain	Residue
A	ALA140
A	ARG141
A	CYS145
A	ALA146
A	PHE147

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site_id	AC2
Number of Residues	3
Details	binding site for residue EDO A 205

Chain	Residue
A	THR89
A	LYS122
A	EDO207

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site_id	AC3
Number of Residues	2
Details	binding site for residue EDO A 206

Chain	Residue
A	THR56
A	ASP51

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site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 207

Chain	Residue
A	GLY16
A	GLY17
A	VAL18
A	EDO205

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	BINDING: BINDING => ECO:0000305|Ref.7, ECO:0007744|PDB:2ERX

Chain	Residue	Details
A	GLY14
A	ARG33
A	ASP61
A	ASN121
A	ALA152

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q5PR73

Chain	Residue	Details
A	SER35
A	SER126

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Cysteine methyl ester => ECO:0000305

Chain	Residue	Details
A	CYS196

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site_id	SWS_FT_FI4
Number of Residues	1
Details	LIPID: S-geranylgeranyl cysteine => ECO:0000305

Chain	Residue	Details
A	CYS196

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