6N3P
Crosslinked AcpP=FabZ complex from E. coli Type II FAS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0009245 | biological_process | lipid A biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016836 | molecular_function | hydro-lyase activity |
| A | 0019171 | molecular_function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| A | 0042802 | molecular_function | identical protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0009245 | biological_process | lipid A biosynthetic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016836 | molecular_function | hydro-lyase activity |
| B | 0019171 | molecular_function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| B | 0042802 | molecular_function | identical protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006629 | biological_process | lipid metabolic process |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0009245 | biological_process | lipid A biosynthetic process |
| C | 0016020 | cellular_component | membrane |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016836 | molecular_function | hydro-lyase activity |
| C | 0019171 | molecular_function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| C | 0042802 | molecular_function | identical protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006629 | biological_process | lipid metabolic process |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0009245 | biological_process | lipid A biosynthetic process |
| D | 0016020 | cellular_component | membrane |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016836 | molecular_function | hydro-lyase activity |
| D | 0019171 | molecular_function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| D | 0042802 | molecular_function | identical protein binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006629 | biological_process | lipid metabolic process |
| E | 0006633 | biological_process | fatty acid biosynthetic process |
| E | 0009245 | biological_process | lipid A biosynthetic process |
| E | 0016020 | cellular_component | membrane |
| E | 0016829 | molecular_function | lyase activity |
| E | 0016836 | molecular_function | hydro-lyase activity |
| E | 0019171 | molecular_function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| E | 0042802 | molecular_function | identical protein binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006629 | biological_process | lipid metabolic process |
| F | 0006633 | biological_process | fatty acid biosynthetic process |
| F | 0009245 | biological_process | lipid A biosynthetic process |
| F | 0016020 | cellular_component | membrane |
| F | 0016829 | molecular_function | lyase activity |
| F | 0016836 | molecular_function | hydro-lyase activity |
| F | 0019171 | molecular_function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| F | 0042802 | molecular_function | identical protein binding |
| G | 0000035 | molecular_function | acyl binding |
| G | 0000036 | molecular_function | acyl carrier activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005829 | cellular_component | cytosol |
| G | 0006629 | biological_process | lipid metabolic process |
| G | 0006631 | biological_process | fatty acid metabolic process |
| G | 0006633 | biological_process | fatty acid biosynthetic process |
| G | 0008289 | molecular_function | lipid binding |
| G | 0008610 | biological_process | lipid biosynthetic process |
| G | 0009245 | biological_process | lipid A biosynthetic process |
| G | 0009410 | biological_process | response to xenobiotic stimulus |
| G | 0016020 | cellular_component | membrane |
| G | 0031177 | molecular_function | phosphopantetheine binding |
| H | 0000035 | molecular_function | acyl binding |
| H | 0000036 | molecular_function | acyl carrier activity |
| H | 0005515 | molecular_function | protein binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005829 | cellular_component | cytosol |
| H | 0006629 | biological_process | lipid metabolic process |
| H | 0006631 | biological_process | fatty acid metabolic process |
| H | 0006633 | biological_process | fatty acid biosynthetic process |
| H | 0008289 | molecular_function | lipid binding |
| H | 0008610 | biological_process | lipid biosynthetic process |
| H | 0009245 | biological_process | lipid A biosynthetic process |
| H | 0009410 | biological_process | response to xenobiotic stimulus |
| H | 0016020 | cellular_component | membrane |
| H | 0031177 | molecular_function | phosphopantetheine binding |
| I | 0000035 | molecular_function | acyl binding |
| I | 0000036 | molecular_function | acyl carrier activity |
| I | 0005515 | molecular_function | protein binding |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0005829 | cellular_component | cytosol |
| I | 0006629 | biological_process | lipid metabolic process |
| I | 0006631 | biological_process | fatty acid metabolic process |
| I | 0006633 | biological_process | fatty acid biosynthetic process |
| I | 0008289 | molecular_function | lipid binding |
| I | 0008610 | biological_process | lipid biosynthetic process |
| I | 0009245 | biological_process | lipid A biosynthetic process |
| I | 0009410 | biological_process | response to xenobiotic stimulus |
| I | 0016020 | cellular_component | membrane |
| I | 0031177 | molecular_function | phosphopantetheine binding |
| J | 0000035 | molecular_function | acyl binding |
| J | 0000036 | molecular_function | acyl carrier activity |
| J | 0005515 | molecular_function | protein binding |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0005829 | cellular_component | cytosol |
| J | 0006629 | biological_process | lipid metabolic process |
| J | 0006631 | biological_process | fatty acid metabolic process |
| J | 0006633 | biological_process | fatty acid biosynthetic process |
| J | 0008289 | molecular_function | lipid binding |
| J | 0008610 | biological_process | lipid biosynthetic process |
| J | 0009245 | biological_process | lipid A biosynthetic process |
| J | 0009410 | biological_process | response to xenobiotic stimulus |
| J | 0016020 | cellular_component | membrane |
| J | 0031177 | molecular_function | phosphopantetheine binding |
| K | 0000035 | molecular_function | acyl binding |
| K | 0000036 | molecular_function | acyl carrier activity |
| K | 0005515 | molecular_function | protein binding |
| K | 0005737 | cellular_component | cytoplasm |
| K | 0005829 | cellular_component | cytosol |
| K | 0006629 | biological_process | lipid metabolic process |
| K | 0006631 | biological_process | fatty acid metabolic process |
| K | 0006633 | biological_process | fatty acid biosynthetic process |
| K | 0008289 | molecular_function | lipid binding |
| K | 0008610 | biological_process | lipid biosynthetic process |
| K | 0009245 | biological_process | lipid A biosynthetic process |
| K | 0009410 | biological_process | response to xenobiotic stimulus |
| K | 0016020 | cellular_component | membrane |
| K | 0031177 | molecular_function | phosphopantetheine binding |
| L | 0000035 | molecular_function | acyl binding |
| L | 0000036 | molecular_function | acyl carrier activity |
| L | 0005515 | molecular_function | protein binding |
| L | 0005737 | cellular_component | cytoplasm |
| L | 0005829 | cellular_component | cytosol |
| L | 0006629 | biological_process | lipid metabolic process |
| L | 0006631 | biological_process | fatty acid metabolic process |
| L | 0006633 | biological_process | fatty acid biosynthetic process |
| L | 0008289 | molecular_function | lipid binding |
| L | 0008610 | biological_process | lipid biosynthetic process |
| L | 0009245 | biological_process | lipid A biosynthetic process |
| L | 0009410 | biological_process | response to xenobiotic stimulus |
| L | 0016020 | cellular_component | membrane |
| L | 0031177 | molecular_function | phosphopantetheine binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | binding site for Di-peptide XLN A 400 and SER I 36 |
| Chain | Residue |
| A | GLU33 |
| A | LYS102 |
| A | ARG103 |
| A | PRO104 |
| A | THR116 |
| A | PHE117 |
| B | HIS19 |
| B | GLU68 |
| B | TYR91 |
| B | TYR92 |
| B | PHE93 |
| A | GLU34 |
| B | LEU124 |
| B | ALA146 |
| I | ASP35 |
| I | LEU37 |
| I | ASP38 |
| I | VAL40 |
| J | ASN24 |
| J | ASN25 |
| A | GLY35 |
| A | PHE37 |
| A | HIS54 |
| A | PHE55 |
| A | PHE61 |
| A | GLY63 |
| A | PHE101 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | binding site for Di-peptide XLN A 400 and SER I 36 |
| Chain | Residue |
| A | GLU33 |
| A | GLU34 |
| A | GLY35 |
| A | PHE37 |
| A | HIS54 |
| A | PHE55 |
| A | PHE61 |
| A | GLY63 |
| A | PHE101 |
| A | LYS102 |
| A | ARG103 |
| A | PRO104 |
| A | THR116 |
| A | PHE117 |
| B | HIS19 |
| B | GLU68 |
| B | TYR91 |
| B | TYR92 |
| B | PHE93 |
| B | LEU124 |
| B | ALA146 |
| I | ASP35 |
| I | LEU37 |
| I | ASP38 |
| I | VAL40 |
| J | ASN24 |
| J | ASN25 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | binding site for Di-peptide XLN B 400 and SER K 36 |
| Chain | Residue |
| A | GLU68 |
| A | TYR91 |
| A | TYR92 |
| A | PHE93 |
| A | HOH503 |
| B | GLU33 |
| B | GLU34 |
| B | GLY35 |
| B | PHE37 |
| B | HIS54 |
| B | PHE55 |
| B | PHE61 |
| B | PRO62 |
| B | GLY63 |
| B | PHE101 |
| B | LYS102 |
| B | PRO104 |
| B | THR116 |
| B | PHE117 |
| H | ASP70 |
| K | ASP35 |
| K | LEU37 |
| K | ASP38 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | binding site for Di-peptide XLN B 400 and SER K 36 |
| Chain | Residue |
| K | ASP38 |
| A | GLU68 |
| A | TYR91 |
| A | TYR92 |
| A | PHE93 |
| A | HOH503 |
| B | GLU33 |
| B | GLU34 |
| B | GLY35 |
| B | PHE37 |
| B | HIS54 |
| B | PHE55 |
| B | PHE61 |
| B | PRO62 |
| B | GLY63 |
| B | PHE101 |
| B | LYS102 |
| B | PRO104 |
| B | THR116 |
| B | PHE117 |
| H | ASP70 |
| K | ASP35 |
| K | LEU37 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide XLN C 400 and HIS C 54 |
| Chain | Residue |
| C | PHE50 |
| C | GLY53 |
| C | PHE55 |
| C | PRO56 |
| C | ILE60 |
| C | PHE61 |
| C | PRO62 |
| C | GLY63 |
| C | PHE101 |
| C | LYS102 |
| C | PRO104 |
| C | HOH502 |
| D | HIS19 |
| D | GLU68 |
| D | TYR91 |
| D | TYR92 |
| D | PHE93 |
| L | SER36 |
| L | LEU37 |
| site_id | AC6 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide XLN C 400 and HIS C 54 |
| Chain | Residue |
| C | PHE50 |
| C | GLY53 |
| C | PHE55 |
| C | PRO56 |
| C | ILE60 |
| C | PHE61 |
| C | PRO62 |
| C | GLY63 |
| C | PHE101 |
| C | LYS102 |
| C | PRO104 |
| C | HOH502 |
| D | HIS19 |
| D | GLU68 |
| D | TYR91 |
| D | TYR92 |
| D | PHE93 |
| L | SER36 |
| L | LEU37 |
| site_id | AC7 |
| Number of Residues | 26 |
| Details | binding site for Di-peptide XLN C 400 and SER L 36 |
| Chain | Residue |
| C | GLU33 |
| C | GLU34 |
| C | GLY35 |
| C | PHE37 |
| C | HIS54 |
| C | PHE55 |
| C | PHE61 |
| C | PRO62 |
| C | GLY63 |
| C | PHE101 |
| C | LYS102 |
| C | PRO104 |
| C | THR116 |
| C | PHE117 |
| C | HOH502 |
| D | HIS19 |
| D | GLU68 |
| D | TYR91 |
| D | TYR92 |
| D | PHE93 |
| L | ASP35 |
| L | LEU37 |
| L | ASP38 |
| L | THR39 |
| L | VAL40 |
| L | GLN66 |
| site_id | AC8 |
| Number of Residues | 26 |
| Details | binding site for Di-peptide XLN C 400 and SER L 36 |
| Chain | Residue |
| C | GLU33 |
| C | GLU34 |
| C | GLY35 |
| C | PHE37 |
| C | HIS54 |
| C | PHE55 |
| C | PHE61 |
| C | PRO62 |
| C | GLY63 |
| C | PHE101 |
| C | LYS102 |
| C | PRO104 |
| C | THR116 |
| C | PHE117 |
| C | HOH502 |
| D | HIS19 |
| D | GLU68 |
| D | TYR91 |
| D | TYR92 |
| D | PHE93 |
| L | ASP35 |
| L | LEU37 |
| L | ASP38 |
| L | THR39 |
| L | VAL40 |
| L | GLN66 |
| site_id | AC9 |
| Number of Residues | 25 |
| Details | binding site for Di-peptide XLN D 400 and SER H 36 |
| Chain | Residue |
| C | HIS19 |
| C | GLU68 |
| C | TYR91 |
| C | TYR92 |
| C | PHE93 |
| D | GLU33 |
| D | GLU34 |
| D | GLY35 |
| D | PHE37 |
| D | HIS54 |
| D | PHE55 |
| D | PHE61 |
| D | PRO62 |
| D | GLY63 |
| D | PHE101 |
| D | LYS102 |
| D | ARG103 |
| D | PRO104 |
| D | THR116 |
| D | PHE117 |
| H | ASP35 |
| H | LEU37 |
| H | ASP38 |
| H | THR39 |
| H | VAL40 |
| site_id | AD1 |
| Number of Residues | 25 |
| Details | binding site for Di-peptide XLN D 400 and SER H 36 |
| Chain | Residue |
| C | HIS19 |
| C | GLU68 |
| C | TYR91 |
| C | TYR92 |
| C | PHE93 |
| D | GLU33 |
| D | GLU34 |
| D | GLY35 |
| D | PHE37 |
| D | HIS54 |
| D | PHE55 |
| D | PHE61 |
| D | PRO62 |
| D | GLY63 |
| D | PHE101 |
| D | LYS102 |
| D | ARG103 |
| D | PRO104 |
| D | THR116 |
| D | PHE117 |
| H | ASP35 |
| H | LEU37 |
| H | ASP38 |
| H | THR39 |
| H | VAL40 |
| site_id | AD2 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide XLN D 400 and HIS D 54 |
| Chain | Residue |
| C | HIS19 |
| C | PHE23 |
| C | GLU68 |
| C | TYR91 |
| C | TYR92 |
| C | PHE93 |
| D | PHE50 |
| D | GLY53 |
| D | PHE55 |
| D | PRO56 |
| D | ILE60 |
| D | PHE61 |
| D | PRO62 |
| D | GLY63 |
| D | PHE101 |
| D | LYS102 |
| D | ARG103 |
| D | PRO104 |
| H | SER36 |
| site_id | AD3 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide XLN D 400 and HIS D 54 |
| Chain | Residue |
| C | HIS19 |
| C | PHE23 |
| C | GLU68 |
| C | TYR91 |
| C | TYR92 |
| C | PHE93 |
| D | PHE50 |
| D | GLY53 |
| D | PHE55 |
| D | PRO56 |
| D | ILE60 |
| D | PHE61 |
| D | PRO62 |
| D | GLY63 |
| D | PHE101 |
| D | LYS102 |
| D | ARG103 |
| D | PRO104 |
| H | SER36 |
| site_id | AD4 |
| Number of Residues | 30 |
| Details | binding site for Di-peptide XLN E 400 and SER G 36 |
| Chain | Residue |
| E | GLU33 |
| E | GLU34 |
| E | GLY35 |
| E | PHE37 |
| E | HIS54 |
| E | PRO62 |
| E | GLY63 |
| E | PHE101 |
| E | LYS102 |
| E | ARG103 |
| E | PRO104 |
| E | THR116 |
| E | PHE117 |
| E | HOH507 |
| F | HIS19 |
| F | GLU68 |
| F | TYR91 |
| F | TYR92 |
| F | PHE93 |
| F | ARG122 |
| G | ASP35 |
| G | LEU37 |
| G | ASP38 |
| G | THR39 |
| G | VAL40 |
| I | LYS61 |
| I | THR63 |
| I | THR64 |
| I | ALA67 |
| K | ALA0 |
| site_id | AD5 |
| Number of Residues | 30 |
| Details | binding site for Di-peptide XLN E 400 and SER G 36 |
| Chain | Residue |
| E | GLU33 |
| E | GLU34 |
| E | GLY35 |
| E | PHE37 |
| E | HIS54 |
| E | PRO62 |
| E | GLY63 |
| E | PHE101 |
| E | LYS102 |
| E | ARG103 |
| E | PRO104 |
| E | THR116 |
| E | PHE117 |
| E | HOH507 |
| F | HIS19 |
| F | GLU68 |
| F | TYR91 |
| F | TYR92 |
| F | PHE93 |
| F | ARG122 |
| G | ASP35 |
| G | LEU37 |
| G | ASP38 |
| G | THR39 |
| G | VAL40 |
| I | LYS61 |
| I | THR63 |
| I | THR64 |
| I | ALA67 |
| K | ALA0 |
| site_id | AD6 |
| Number of Residues | 21 |
| Details | binding site for Di-peptide XLN E 400 and HIS E 54 |
| Chain | Residue |
| E | PHE50 |
| E | GLY53 |
| E | PHE55 |
| E | PRO56 |
| E | ILE60 |
| E | PRO62 |
| E | GLY63 |
| E | PHE101 |
| E | LYS102 |
| E | ARG103 |
| E | PRO104 |
| E | HOH507 |
| F | HIS19 |
| F | PHE23 |
| F | GLU68 |
| F | TYR91 |
| F | TYR92 |
| F | PHE93 |
| F | ARG122 |
| G | SER36 |
| K | ALA0 |
| site_id | AD7 |
| Number of Residues | 21 |
| Details | binding site for Di-peptide XLN E 400 and HIS E 54 |
| Chain | Residue |
| E | PHE50 |
| E | GLY53 |
| E | PHE55 |
| E | PRO56 |
| E | ILE60 |
| E | PRO62 |
| E | GLY63 |
| E | PHE101 |
| E | LYS102 |
| E | ARG103 |
| E | PRO104 |
| E | HOH507 |
| F | HIS19 |
| F | PHE23 |
| F | GLU68 |
| F | TYR91 |
| F | TYR92 |
| F | PHE93 |
| F | ARG122 |
| G | SER36 |
| K | ALA0 |
| site_id | AD8 |
| Number of Residues | 22 |
| Details | binding site for Di-peptide XLN F 400 and SER J 36 |
| Chain | Residue |
| E | HIS19 |
| E | GLU68 |
| E | TYR91 |
| E | TYR92 |
| E | PHE93 |
| E | SER148 |
| E | GLU150 |
| F | GLU33 |
| F | GLU34 |
| F | GLY35 |
| F | PHE37 |
| F | HIS54 |
| F | PHE55 |
| F | ILE60 |
| F | GLY63 |
| F | ARG103 |
| F | PRO104 |
| F | THR116 |
| F | PHE117 |
| J | ASP35 |
| J | LEU37 |
| J | HOH501 |
| site_id | AD9 |
| Number of Residues | 18 |
| Details | binding site for Di-peptide XLN F 400 and HIS F 54 |
| Chain | Residue |
| E | HIS19 |
| E | GLU68 |
| E | TYR91 |
| E | TYR92 |
| E | PHE93 |
| E | SER148 |
| E | GLU150 |
| F | PHE50 |
| F | GLY53 |
| F | PHE55 |
| F | PRO56 |
| F | ILE60 |
| F | GLY63 |
| F | ARG103 |
| F | PRO104 |
| J | ASP35 |
| J | SER36 |
| J | HOH501 |
Functional Information from PROSITE/UniProt
| site_id | PS00012 |
| Number of Residues | 16 |
| Details | PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGADSLDTVELVMAL |
| Chain | Residue | Details |
| G | ASP31-LEU46 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"4882207","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 75 |
| Details | Domain: {"description":"Carrier","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
