6MZM

Human TFIID bound to promoter DNA and TFIIA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0005669	cellular_component	transcription factor TFIID complex
A	0006366	biological_process	transcription by RNA polymerase II
A	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
A	0017025	molecular_function	TBP-class protein binding
B	0000086	biological_process	G2/M transition of mitotic cell cycle
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0003682	molecular_function	chromatin binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005669	cellular_component	transcription factor TFIID complex
B	0006282	biological_process	regulation of DNA repair
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0014070	biological_process	response to organic cyclic compound
B	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
B	0033276	cellular_component	transcription factor TFTC complex
B	0042789	biological_process	mRNA transcription by RNA polymerase II
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0051123	biological_process	RNA polymerase II preinitiation complex assembly
B	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
D	0000785	cellular_component	chromatin
D	0001046	molecular_function	core promoter sequence-specific DNA binding
D	0001541	biological_process	ovarian follicle development
D	0001673	cellular_component	male germ cell nucleus
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005667	cellular_component	transcription regulator complex
D	0005669	cellular_component	transcription factor TFIID complex
D	0005829	cellular_component	cytosol
D	0006282	biological_process	regulation of DNA repair
D	0006351	biological_process	DNA-templated transcription
D	0006352	biological_process	DNA-templated transcription initiation
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006366	biological_process	transcription by RNA polymerase II
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
D	0017162	molecular_function	aryl hydrocarbon receptor binding
D	0032991	cellular_component	protein-containing complex
D	0033276	cellular_component	transcription factor TFTC complex
D	0042789	biological_process	mRNA transcription by RNA polymerase II
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0046982	molecular_function	protein heterodimerization activity
D	0051123	biological_process	RNA polymerase II preinitiation complex assembly
D	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
D	0071339	cellular_component	MLL1 complex
G	0000785	cellular_component	chromatin
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005669	cellular_component	transcription factor TFIID complex
G	0005730	cellular_component	nucleolus
G	0006282	biological_process	regulation of DNA repair
G	0006352	biological_process	DNA-templated transcription initiation
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0015629	cellular_component	actin cytoskeleton
G	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
G	0033276	cellular_component	transcription factor TFTC complex
G	0042789	biological_process	mRNA transcription by RNA polymerase II
G	0042802	molecular_function	identical protein binding
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	0051123	biological_process	RNA polymerase II preinitiation complex assembly
G	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
H	0000124	cellular_component	SAGA complex
H	0003677	molecular_function	DNA binding
H	0003713	molecular_function	transcription coactivator activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005669	cellular_component	transcription factor TFIID complex
H	0005829	cellular_component	cytosol
H	0006282	biological_process	regulation of DNA repair
H	0006352	biological_process	DNA-templated transcription initiation
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0006366	biological_process	transcription by RNA polymerase II
H	0006367	biological_process	transcription initiation at RNA polymerase II promoter
H	0006915	biological_process	apoptotic process
H	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
H	0017162	molecular_function	aryl hydrocarbon receptor binding
H	0032991	cellular_component	protein-containing complex
H	0033276	cellular_component	transcription factor TFTC complex
H	0042789	biological_process	mRNA transcription by RNA polymerase II
H	0045786	biological_process	negative regulation of cell cycle
H	0045893	biological_process	positive regulation of DNA-templated transcription
H	0046695	cellular_component	SLIK (SAGA-like) complex
H	0046982	molecular_function	protein heterodimerization activity
H	0051123	biological_process	RNA polymerase II preinitiation complex assembly
H	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
H	0071339	cellular_component	MLL1 complex
I	0000124	cellular_component	SAGA complex
I	0003677	molecular_function	DNA binding
I	0003713	molecular_function	transcription coactivator activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005669	cellular_component	transcription factor TFIID complex
I	0005829	cellular_component	cytosol
I	0006282	biological_process	regulation of DNA repair
I	0006352	biological_process	DNA-templated transcription initiation
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0006366	biological_process	transcription by RNA polymerase II
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0006915	biological_process	apoptotic process
I	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
I	0017162	molecular_function	aryl hydrocarbon receptor binding
I	0032991	cellular_component	protein-containing complex
I	0033276	cellular_component	transcription factor TFTC complex
I	0042789	biological_process	mRNA transcription by RNA polymerase II
I	0045786	biological_process	negative regulation of cell cycle
I	0045893	biological_process	positive regulation of DNA-templated transcription
I	0046695	cellular_component	SLIK (SAGA-like) complex
I	0046982	molecular_function	protein heterodimerization activity
I	0051123	biological_process	RNA polymerase II preinitiation complex assembly
I	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
I	0071339	cellular_component	MLL1 complex
J	0000122	biological_process	negative regulation of transcription by RNA polymerase II
J	0000296	biological_process	spermine transport
J	0000976	molecular_function	transcription cis-regulatory region binding
J	0001097	molecular_function	TFIIH-class transcription factor complex binding
J	0001673	cellular_component	male germ cell nucleus
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005667	cellular_component	transcription regulator complex
J	0005669	cellular_component	transcription factor TFIID complex
J	0005737	cellular_component	cytoplasm
J	0006282	biological_process	regulation of DNA repair
J	0006352	biological_process	DNA-templated transcription initiation
J	0006357	biological_process	regulation of transcription by RNA polymerase II
J	0006366	biological_process	transcription by RNA polymerase II
J	0006367	biological_process	transcription initiation at RNA polymerase II promoter
J	0006469	biological_process	negative regulation of protein kinase activity
J	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
J	0030520	biological_process	estrogen receptor signaling pathway
J	0033276	cellular_component	transcription factor TFTC complex
J	0035035	molecular_function	histone acetyltransferase binding
J	0042789	biological_process	mRNA transcription by RNA polymerase II
J	0042809	molecular_function	nuclear vitamin D receptor binding
J	0045344	biological_process	negative regulation of MHC class I biosynthetic process
J	0045347	biological_process	negative regulation of MHC class II biosynthetic process
J	0045892	biological_process	negative regulation of DNA-templated transcription
J	0045893	biological_process	positive regulation of DNA-templated transcription
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0046966	molecular_function	nuclear thyroid hormone receptor binding
J	0046982	molecular_function	protein heterodimerization activity
J	0051123	biological_process	RNA polymerase II preinitiation complex assembly
J	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
J	0061628	molecular_function	H3K27me3 modified histone binding
J	0071339	cellular_component	MLL1 complex
J	0106140	molecular_function	P-TEFb complex binding
J	0140297	molecular_function	DNA-binding transcription factor binding
K	0001112	biological_process	DNA-templated transcription open complex formation
K	0001833	biological_process	inner cell mass cell proliferation
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005669	cellular_component	transcription factor TFIID complex
K	0005737	cellular_component	cytoplasm
K	0006367	biological_process	transcription initiation at RNA polymerase II promoter
K	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
K	0030154	biological_process	cell differentiation
K	0042789	biological_process	mRNA transcription by RNA polymerase II
K	0045598	biological_process	regulation of fat cell differentiation
K	0046982	molecular_function	protein heterodimerization activity
K	0048471	cellular_component	perinuclear region of cytoplasm
K	0051123	biological_process	RNA polymerase II preinitiation complex assembly
K	0051457	biological_process	maintenance of protein location in nucleus
K	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
L	0000124	cellular_component	SAGA complex
L	0000492	biological_process	box C/D snoRNP assembly
L	0000976	molecular_function	transcription cis-regulatory region binding
L	0002039	molecular_function	p53 binding
L	0003677	molecular_function	DNA binding
L	0003713	molecular_function	transcription coactivator activity
L	0004402	molecular_function	histone acetyltransferase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005669	cellular_component	transcription factor TFIID complex
L	0006282	biological_process	regulation of DNA repair
L	0006338	biological_process	chromatin remodeling
L	0006352	biological_process	DNA-templated transcription initiation
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0006974	biological_process	DNA damage response
L	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
L	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
L	0033276	cellular_component	transcription factor TFTC complex
L	0042789	biological_process	mRNA transcription by RNA polymerase II
L	0043066	biological_process	negative regulation of apoptotic process
L	0043484	biological_process	regulation of RNA splicing
L	0045893	biological_process	positive regulation of DNA-templated transcription
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0046982	molecular_function	protein heterodimerization activity
L	0050821	biological_process	protein stabilization
L	0051117	molecular_function	ATPase binding
L	0051123	biological_process	RNA polymerase II preinitiation complex assembly
L	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
L	0060760	biological_process	positive regulation of response to cytokine stimulus
L	0070555	biological_process	response to interleukin-1
L	0070742	molecular_function	C2H2 zinc finger domain binding
L	0070761	cellular_component	pre-snoRNP complex
L	0071339	cellular_component	MLL1 complex
L	0140297	molecular_function	DNA-binding transcription factor binding
L	1902065	biological_process	response to L-glutamate
L	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
O	0000082	biological_process	G1/S transition of mitotic cell cycle
O	0000124	cellular_component	SAGA complex
O	0001673	cellular_component	male germ cell nucleus
O	0001701	biological_process	in utero embryonic development
O	0001756	biological_process	somitogenesis
O	0001889	biological_process	liver development
O	0001892	biological_process	embryonic placenta development
O	0003677	molecular_function	DNA binding
O	0004402	molecular_function	histone acetyltransferase activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005669	cellular_component	transcription factor TFIID complex
O	0005737	cellular_component	cytoplasm
O	0006282	biological_process	regulation of DNA repair
O	0006338	biological_process	chromatin remodeling
O	0006352	biological_process	DNA-templated transcription initiation
O	0006355	biological_process	regulation of DNA-templated transcription
O	0006357	biological_process	regulation of transcription by RNA polymerase II
O	0006366	biological_process	transcription by RNA polymerase II
O	0006367	biological_process	transcription initiation at RNA polymerase II promoter
O	0006915	biological_process	apoptotic process
O	0010467	biological_process	gene expression
O	0010468	biological_process	regulation of gene expression
O	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
O	0019899	molecular_function	enzyme binding
O	0030331	molecular_function	nuclear estrogen receptor binding
O	0033276	cellular_component	transcription factor TFTC complex
O	0035264	biological_process	multicellular organism growth
O	0036285	biological_process	SAGA complex assembly
O	0042789	biological_process	mRNA transcription by RNA polymerase II
O	0042802	molecular_function	identical protein binding
O	0043484	biological_process	regulation of RNA splicing
O	0045893	biological_process	positive regulation of DNA-templated transcription
O	0048371	biological_process	lateral mesodermal cell differentiation
O	0048471	cellular_component	perinuclear region of cytoplasm
O	0051123	biological_process	RNA polymerase II preinitiation complex assembly
O	0060173	biological_process	limb development
O	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
O	0065003	biological_process	protein-containing complex assembly
O	0070063	molecular_function	RNA polymerase binding
O	0070365	biological_process	hepatocyte differentiation
O	0097550	cellular_component	transcription preinitiation complex
O	1905069	biological_process	allantois development
O	1990841	molecular_function	promoter-specific chromatin binding
R	0000124	cellular_component	SAGA complex
R	0003677	molecular_function	DNA binding
R	0003713	molecular_function	transcription coactivator activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005669	cellular_component	transcription factor TFIID complex
R	0006282	biological_process	regulation of DNA repair
R	0006352	biological_process	DNA-templated transcription initiation
R	0006355	biological_process	regulation of DNA-templated transcription
R	0006357	biological_process	regulation of transcription by RNA polymerase II
R	0006366	biological_process	transcription by RNA polymerase II
R	0006367	biological_process	transcription initiation at RNA polymerase II promoter
R	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
R	0017025	molecular_function	TBP-class protein binding
R	0033276	cellular_component	transcription factor TFTC complex
R	0042789	biological_process	mRNA transcription by RNA polymerase II
R	0043484	biological_process	regulation of RNA splicing
R	0045893	biological_process	positive regulation of DNA-templated transcription
R	0045944	biological_process	positive regulation of transcription by RNA polymerase II
R	0046982	molecular_function	protein heterodimerization activity
R	0051123	biological_process	RNA polymerase II preinitiation complex assembly
R	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
R	0140297	molecular_function	DNA-binding transcription factor binding
T	0000785	cellular_component	chromatin
T	0000791	cellular_component	euchromatin
T	0000976	molecular_function	transcription cis-regulatory region binding
T	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
T	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
T	0000995	molecular_function	RNA polymerase III general transcription initiation factor activity
T	0001046	molecular_function	core promoter sequence-specific DNA binding
T	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
T	0001093	molecular_function	TFIIB-class transcription factor binding
T	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
T	0001188	biological_process	RNA polymerase I preinitiation complex assembly
T	0001673	cellular_component	male germ cell nucleus
T	0001674	cellular_component	female germ cell nucleus
T	0001939	cellular_component	female pronucleus
T	0001940	cellular_component	male pronucleus
T	0003677	molecular_function	DNA binding
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005668	cellular_component	RNA polymerase transcription factor SL1 complex
T	0005669	cellular_component	transcription factor TFIID complex
T	0005672	cellular_component	transcription factor TFIIA complex
T	0005737	cellular_component	cytoplasm
T	0006352	biological_process	DNA-templated transcription initiation
T	0006366	biological_process	transcription by RNA polymerase II
T	0006367	biological_process	transcription initiation at RNA polymerase II promoter
T	0006383	biological_process	transcription by RNA polymerase III
T	0007283	biological_process	spermatogenesis
T	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
T	0017162	molecular_function	aryl hydrocarbon receptor binding
T	0019899	molecular_function	enzyme binding
T	0032991	cellular_component	protein-containing complex
T	0042789	biological_process	mRNA transcription by RNA polymerase II
T	0045120	cellular_component	pronucleus
T	0045893	biological_process	positive regulation of DNA-templated transcription
T	0051123	biological_process	RNA polymerase II preinitiation complex assembly
T	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
T	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
T	0140297	molecular_function	DNA-binding transcription factor binding
W	0005672	cellular_component	transcription factor TFIIA complex
W	0006367	biological_process	transcription initiation at RNA polymerase II promoter
X	0005672	cellular_component	transcription factor TFIIA complex
X	0006367	biological_process	transcription initiation at RNA polymerase II promoter

Functional Information from PROSITE/UniProt

site_id	PS00351
Number of Residues	50
Details	TFIID Transcription factor TFIID repeat signature. YnPkrFaaVImRirePRttaLIFsSGKMvctGAKseeqsrlAarkyarvV

Chain	Residue	Details
T	TYR192-VAL241
T	TYR283-LEU332

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. VATGsaDrTVRLWDV

Chain	Residue	Details
G	VAL642-VAL656
G	LEU684-ILE698
G	LEU726-ALA740

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:27193682, ECO:0007744|PDB:5IYD

Chain	Residue	Details
T	ASN167
T	ARG203
T	LYS218
T	ASN257
T	ARG294

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by TASP1

Chain	Residue	Details
R	SER51
J	SER201
B	SER1198

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by TAF1 => ECO:0000269|PubMed:11278496

Chain	Residue	Details
R	THR59
D	LYS595
D	LYS597
D	LYS605
D	LYS611
D	LYS621
D	LYS631
D	LYS658

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by TAF1 => ECO:0000269|PubMed:11278496, ECO:0007744|PubMed:17081983

Chain	Residue	Details
R	LYS19
L	SER196

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8VI33

Chain	Residue	Details
L	SER155

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
L	SER158

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
L	THR159
I	GLY646

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
L	THR161

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q8VI33

Chain	Residue	Details
L	THR164

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
L	THR178

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
L	SER181

---