6MWJ
Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) Burkholderia pseudomallei in complex with ligand HGN-0863
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0008685 | molecular_function | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity |
| A | 0016114 | biological_process | terpenoid biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0008685 | molecular_function | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity |
| B | 0016114 | biological_process | terpenoid biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0008299 | biological_process | isoprenoid biosynthetic process |
| C | 0008685 | molecular_function | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity |
| C | 0016114 | biological_process | terpenoid biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| C | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 200 |
| Chain | Residue |
| A | ASP10 |
| A | HIS12 |
| A | HIS44 |
| A | AZM201 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue AZM A 201 |
| Chain | Residue |
| A | GLY60 |
| A | PHE63 |
| A | ASP65 |
| A | PHE70 |
| A | LEU78 |
| A | ZN200 |
| B | LYS134 |
| A | ASP10 |
| A | HIS12 |
| A | SER37 |
| A | HIS44 |
| A | ILE59 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue DMS A 202 |
| Chain | Residue |
| A | ALA102 |
| A | GLN103 |
| A | PRO105 |
| A | LYS106 |
| A | LEU107 |
| A | LYS134 |
| A | THR135 |
| A | HOH313 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 201 |
| Chain | Residue |
| B | ASP10 |
| B | HIS12 |
| B | HIS44 |
| B | HOH347 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue DMS B 202 |
| Chain | Residue |
| B | ALA102 |
| B | PRO105 |
| B | LYS106 |
| B | LEU107 |
| B | HOH313 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue ZN C 201 |
| Chain | Residue |
| C | ASP10 |
| C | HIS12 |
| C | HIS44 |
| C | HOH309 |
| C | HOH359 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue DMS C 202 |
| Chain | Residue |
| C | ALA102 |
| C | PRO105 |
| C | LYS106 |
| C | LEU107 |
| C | ALA133 |
| C | LYS134 |
Functional Information from PROSITE/UniProt
| site_id | PS01350 |
| Number of Residues | 16 |
| Details | ISPF 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature. SDADVLlHAitDAlfG |
| Chain | Residue | Details |
| A | SER37-GLY52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 35 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00107","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"HAMAP-Rule","id":"MF_00107","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
