6MSD

Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome

This is a large structure.
?

Functional Information from GO Data

ChainGOidnamespacecontents
?

Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC14binding site for residue ZN c 401
ChainResidue
cGLU52
cHIS113
cHIS115
cASP126

AC217binding site for residue ATP A 501
ChainResidue
AASP176
AGLY178
APRO218
AGLY219
ATHR220
AGLY221
ALYS222
ATHR223
ALEU224
AILE354
AHIS358
AGLY382
AALA383
AMG502
BASP317
BARG343
BARG346

AC32binding site for residue MG A 502
ChainResidue
ATHR223
AATP501

AC414binding site for residue ATP B 501
ChainResidue
BILE187
BPRO228
BGLY229
BTHR230
BGLY231
BLYS232
BTHR233
BLEU234
BHIS368
BGLY392
BALA393
BLYS396
BMG502
CARG307

AC52binding site for residue MG B 502
ChainResidue
BTHR233
BATP501

AC612binding site for residue ADP C 501
ChainResidue
CMET150
CGLY152
CPRO192
CGLY193
CTHR194
CGLY195
CLYS196
CTHR197
CLEU198
CILE328
CGLY356
CLYS360

AC715binding site for residue ATP D 501
ChainResidue
DILE167
DGLY168
DPRO208
DGLY209
DCYS210
DGLY211
DLYS212
DTHR213
DMET214
DGLY372
DALA373
DASN376
DMG502
EARG291
EARG294

AC82binding site for residue MG D 502
ChainResidue
DTHR213
DATP501

AC918binding site for residue ATP E 401
ChainResidue
EILE135
EGLY136
EPRO176
EGLY177
ETHR178
EGLY179
ELYS180
ETHR181
ELEU182
EGLU234
EASN280
EILE312
EHIS316
EGLY340
EALA341
EMG402
FARG344
FARG347

AD12binding site for residue MG E 402
ChainResidue
ETHR181
EATP401

AD213binding site for residue ADP F 501
ChainResidue
FGLY189
FPRO229
FGLY230
FTHR231
FGLY232
FLYS233
FTHR234
FLEU235
FILE365
FHIS369
FGLY393
FLYS397
FMG502

AD34binding site for residue MG F 502
ChainResidue
FTHR234
FASP286
FGLU287
FADP501

?

Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
ATP_6msd_A_50123ADENOSINE-5'-TRIPHOSPHATE binding site
ChainResidueligand
AASP176-GLY178ATP: ADENOSINE-5'-TRIPHOSPHATE
ACYS180ATP: ADENOSINE-5'-TRIPHOSPHATE
APRO217-LEU224ATP: ADENOSINE-5'-TRIPHOSPHATE
AGLU276ATP: ADENOSINE-5'-TRIPHOSPHATE
AASN322ATP: ADENOSINE-5'-TRIPHOSPHATE
AILE354ATP: ADENOSINE-5'-TRIPHOSPHATE
AILE357-HIS358ATP: ADENOSINE-5'-TRIPHOSPHATE
AGLY382-ALA383ATP: ADENOSINE-5'-TRIPHOSPHATE
AARG386ATP: ADENOSINE-5'-TRIPHOSPHATE
BASP317ATP: ADENOSINE-5'-TRIPHOSPHATE
BARG343ATP: ADENOSINE-5'-TRIPHOSPHATE
BARG346ATP: ADENOSINE-5'-TRIPHOSPHATE

ADP_6msd_F_50124ADENOSINE-5'-DIPHOSPHATE binding site
ChainResidueligand
AARG333ADP: ADENOSINE-5'-DIPHOSPHATE
AARG336ADP: ADENOSINE-5'-DIPHOSPHATE
FASP187-GLY189ADP: ADENOSINE-5'-DIPHOSPHATE
FLEU191ADP: ADENOSINE-5'-DIPHOSPHATE
FPRO228-LEU235ADP: ADENOSINE-5'-DIPHOSPHATE
FARG238ADP: ADENOSINE-5'-DIPHOSPHATE
FASP286-GLU287ADP: ADENOSINE-5'-DIPHOSPHATE
FASN333ADP: ADENOSINE-5'-DIPHOSPHATE
FILE365ADP: ADENOSINE-5'-DIPHOSPHATE
FILE368-HIS369ADP: ADENOSINE-5'-DIPHOSPHATE
FGLY393-ALA394ADP: ADENOSINE-5'-DIPHOSPHATE
FLYS397ADP: ADENOSINE-5'-DIPHOSPHATE

ATP_6msd_B_50122ADENOSINE-5'-TRIPHOSPHATE binding site
ChainResidueligand
BASP186-GLY188ATP: ADENOSINE-5'-TRIPHOSPHATE
BLEU190ATP: ADENOSINE-5'-TRIPHOSPHATE
BPRO227-LEU234ATP: ADENOSINE-5'-TRIPHOSPHATE
BASP285ATP: ADENOSINE-5'-TRIPHOSPHATE
BASN332ATP: ADENOSINE-5'-TRIPHOSPHATE
BILE364ATP: ADENOSINE-5'-TRIPHOSPHATE
BILE367-HIS368ATP: ADENOSINE-5'-TRIPHOSPHATE
BGLY392-ALA393ATP: ADENOSINE-5'-TRIPHOSPHATE
BLYS396ATP: ADENOSINE-5'-TRIPHOSPHATE
CARG307ATP: ADENOSINE-5'-TRIPHOSPHATE
CARG310ATP: ADENOSINE-5'-TRIPHOSPHATE

ADP_6msd_C_50117ADENOSINE-5'-DIPHOSPHATE binding site
ChainResidueligand
CMET150-GLY152ADP: ADENOSINE-5'-DIPHOSPHATE
CLEU154ADP: ADENOSINE-5'-DIPHOSPHATE
CPRO191-LEU198ADP: ADENOSINE-5'-DIPHOSPHATE
CASP249ADP: ADENOSINE-5'-DIPHOSPHATE
CILE328ADP: ADENOSINE-5'-DIPHOSPHATE
CGLY356-ALA357ADP: ADENOSINE-5'-DIPHOSPHATE
CLYS360ADP: ADENOSINE-5'-DIPHOSPHATE

ATP_6msd_D_50125ADENOSINE-5'-TRIPHOSPHATE binding site
ChainResidueligand
DASP166-GLY168ATP: ADENOSINE-5'-TRIPHOSPHATE
DMET170ATP: ADENOSINE-5'-TRIPHOSPHATE
DPRO207-LEU215ATP: ADENOSINE-5'-TRIPHOSPHATE
DASN312ATP: ADENOSINE-5'-TRIPHOSPHATE
DILE344ATP: ADENOSINE-5'-TRIPHOSPHATE
DTHR347-ILE348ATP: ADENOSINE-5'-TRIPHOSPHATE
DGLY372-ALA373ATP: ADENOSINE-5'-TRIPHOSPHATE
DASN376ATP: ADENOSINE-5'-TRIPHOSPHATE
EASP265ATP: ADENOSINE-5'-TRIPHOSPHATE
EALA288ATP: ADENOSINE-5'-TRIPHOSPHATE
EARG291ATP: ADENOSINE-5'-TRIPHOSPHATE
EGLY293-ARG294ATP: ADENOSINE-5'-TRIPHOSPHATE

ATP_6msd_E_40126ADENOSINE-5'-TRIPHOSPHATE binding site
ChainResidueligand
EGLU134-GLY136ATP: ADENOSINE-5'-TRIPHOSPHATE
ELEU138ATP: ADENOSINE-5'-TRIPHOSPHATE
EPRO175-LEU183ATP: ADENOSINE-5'-TRIPHOSPHATE
EGLU234ATP: ADENOSINE-5'-TRIPHOSPHATE
EASN280ATP: ADENOSINE-5'-TRIPHOSPHATE
EILE312ATP: ADENOSINE-5'-TRIPHOSPHATE
EILE315-HIS316ATP: ADENOSINE-5'-TRIPHOSPHATE
EGLY340-ALA341ATP: ADENOSINE-5'-TRIPHOSPHATE
EARG344ATP: ADENOSINE-5'-TRIPHOSPHATE
FASP318-GLY319ATP: ADENOSINE-5'-TRIPHOSPHATE
FALA341ATP: ADENOSINE-5'-TRIPHOSPHATE
FARG344ATP: ADENOSINE-5'-TRIPHOSPHATE
FARG347ATP: ADENOSINE-5'-TRIPHOSPHATE

?

Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
?

Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
?

Catalytic Information from CSA

site_idNumber of ResiduesDetails
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2019 Protein Data Bank Japan