6MSD

Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome

This is a large structure.
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Functional Information from GO Data

ChainGOidnamespacecontents
B0005829cellular_componentcytosol
B0016020cellular_componentmembrane
B0005654cellular_componentnucleoplasm
B0005634cellular_componentnucleus
B0022624cellular_componentproteasome accessory complex
B0000502cellular_componentproteasome complex
B0008540cellular_componentproteasome regulatory particle, base subcomplex
B0005524molecular_functionATP binding
B0016887molecular_functionATPase activity
B0036402molecular_functionproteasome-activating ATPase activity
B0003723molecular_functionRNA binding
B0017025molecular_functionTBP-class protein binding
B0031145biological_processanaphase-promoting complex-dependent catabolic process
B0002479biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
B0038095biological_processFc-epsilon receptor signaling pathway
B0070498biological_processinterleukin-1-mediated signaling pathway
B0000165biological_processMAPK cascade
B0090090biological_processnegative regulation of canonical Wnt signaling pathway
B0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
B1901215biological_processnegative regulation of neuron death
B0038061biological_processNIK/NF-kappaB signaling
B0090263biological_processpositive regulation of canonical Wnt signaling pathway
B0043687biological_processpost-translational protein modification
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0016579biological_processprotein deubiquitination
B0006457biological_processprotein folding
B0000209biological_processprotein polyubiquitination
B0006521biological_processregulation of cellular amino acid metabolic process
B1902036biological_processregulation of hematopoietic stem cell differentiation
B1901990biological_processregulation of mitotic cell cycle phase transition
B0043488biological_processregulation of mRNA stability
B0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
B0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B0002223biological_processstimulatory C-type lectin receptor signaling pathway
B0050852biological_processT cell receptor signaling pathway
B0055085biological_processtransmembrane transport
B0033209biological_processtumor necrosis factor-mediated signaling pathway
B0060071biological_processWnt signaling pathway, planar cell polarity pathway
F0005829cellular_componentcytosol
F0005576cellular_componentextracellular region
F1904813cellular_componentficolin-1-rich granule lumen
F0016020cellular_componentmembrane
F0005654cellular_componentnucleoplasm
F0005634cellular_componentnucleus
F0000932cellular_componentP-body
F0022624cellular_componentproteasome accessory complex
F0000502cellular_componentproteasome complex
F0008540cellular_componentproteasome regulatory particle, base subcomplex
F0034774cellular_componentsecretory granule lumen
F0005524molecular_functionATP binding
F0016887molecular_functionATPase activity
F0042802molecular_functionidentical protein binding
F0031145biological_processanaphase-promoting complex-dependent catabolic process
F0002479biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
F0001824biological_processblastocyst development
F0038095biological_processFc-epsilon receptor signaling pathway
F0070498biological_processinterleukin-1-mediated signaling pathway
F0000165biological_processMAPK cascade
F0043921biological_processmodulation by host of viral transcription
F0090090biological_processnegative regulation of canonical Wnt signaling pathway
F0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
F0043312biological_processneutrophil degranulation
F0038061biological_processNIK/NF-kappaB signaling
F0090263biological_processpositive regulation of canonical Wnt signaling pathway
F0045899biological_processpositive regulation of RNA polymerase II transcriptional preinitiation complex assembly
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F0043687biological_processpost-translational protein modification
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0016579biological_processprotein deubiquitination
F0000209biological_processprotein polyubiquitination
F0006521biological_processregulation of cellular amino acid metabolic process
F1902036biological_processregulation of hematopoietic stem cell differentiation
F1901990biological_processregulation of mitotic cell cycle phase transition
F0043488biological_processregulation of mRNA stability
F0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
F0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
F0002223biological_processstimulatory C-type lectin receptor signaling pathway
F0050852biological_processT cell receptor signaling pathway
F0055085biological_processtransmembrane transport
F0033209biological_processtumor necrosis factor-mediated signaling pathway
F0016032biological_processviral process
F0060071biological_processWnt signaling pathway, planar cell polarity pathway
D0005829cellular_componentcytosol
D0031597cellular_componentcytosolic proteasome complex
D0016234cellular_componentinclusion body
D0016020cellular_componentmembrane
D0005654cellular_componentnucleoplasm
D0005634cellular_componentnucleus
D0022624cellular_componentproteasome accessory complex
D0000502cellular_componentproteasome complex
D0008540cellular_componentproteasome regulatory particle, base subcomplex
D0045202cellular_componentsynapse
D0005524molecular_functionATP binding
D0016887molecular_functionATPase activity
D0036402molecular_functionproteasome-activating ATPase activity
D0031145biological_processanaphase-promoting complex-dependent catabolic process
D0002479biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
D0001824biological_processblastocyst development
D0038095biological_processFc-epsilon receptor signaling pathway
D0070498biological_processinterleukin-1-mediated signaling pathway
D0000165biological_processMAPK cascade
D0090090biological_processnegative regulation of canonical Wnt signaling pathway
D0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
D0038061biological_processNIK/NF-kappaB signaling
D0090263biological_processpositive regulation of canonical Wnt signaling pathway
D0045899biological_processpositive regulation of RNA polymerase II transcriptional preinitiation complex assembly
D0043687biological_processpost-translational protein modification
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0016579biological_processprotein deubiquitination
D0000209biological_processprotein polyubiquitination
D0006508biological_processproteolysis
D0006521biological_processregulation of cellular amino acid metabolic process
D1902036biological_processregulation of hematopoietic stem cell differentiation
D1901990biological_processregulation of mitotic cell cycle phase transition
D0043488biological_processregulation of mRNA stability
D0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
D0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D0002223biological_processstimulatory C-type lectin receptor signaling pathway
D0050852biological_processT cell receptor signaling pathway
D0055085biological_processtransmembrane transport
D0033209biological_processtumor necrosis factor-mediated signaling pathway
D0060071biological_processWnt signaling pathway, planar cell polarity pathway
A0005737cellular_componentcytoplasm
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0005829cellular_componentcytosol
A0043197cellular_componentdendritic spine
A0005576cellular_componentextracellular region
A1904813cellular_componentficolin-1-rich granule lumen
A0016020cellular_componentmembrane
A0005654cellular_componentnucleoplasm
A0005634cellular_componentnucleus
A0000932cellular_componentP-body
A0022624cellular_componentproteasome accessory complex
A0000502cellular_componentproteasome complex
A0008540cellular_componentproteasome regulatory particle, base subcomplex
A0034774cellular_componentsecretory granule lumen
A0005524molecular_functionATP binding
A0016887molecular_functionATPase activity
A0036402molecular_functionproteasome-activating ATPase activity
A0017025molecular_functionTBP-class protein binding
A0031145biological_processanaphase-promoting complex-dependent catabolic process
A0002479biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
A0038095biological_processFc-epsilon receptor signaling pathway
A0070498biological_processinterleukin-1-mediated signaling pathway
A0000165biological_processMAPK cascade
A0090090biological_processnegative regulation of canonical Wnt signaling pathway
A0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
A0043312biological_processneutrophil degranulation
A0038061biological_processNIK/NF-kappaB signaling
A0001649biological_processosteoblast differentiation
A0090263biological_processpositive regulation of canonical Wnt signaling pathway
A0045899biological_processpositive regulation of RNA polymerase II transcriptional preinitiation complex assembly
A0043687biological_processpost-translational protein modification
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0016579biological_processprotein deubiquitination
A0000209biological_processprotein polyubiquitination
A0006521biological_processregulation of cellular amino acid metabolic process
A1902036biological_processregulation of hematopoietic stem cell differentiation
A1901990biological_processregulation of mitotic cell cycle phase transition
A0043488biological_processregulation of mRNA stability
A0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
A0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A0002223biological_processstimulatory C-type lectin receptor signaling pathway
A0050852biological_processT cell receptor signaling pathway
A0055085biological_processtransmembrane transport
A0033209biological_processtumor necrosis factor-mediated signaling pathway
A0006511biological_processubiquitin-dependent protein catabolic process
A0060071biological_processWnt signaling pathway, planar cell polarity pathway
C0072562cellular_componentblood microparticle
C0005737cellular_componentcytoplasm
C0031410cellular_componentcytoplasmic vesicle
C0005829cellular_componentcytosol
C0031597cellular_componentcytosolic proteasome complex
C0070062cellular_componentextracellular exosome
C0016234cellular_componentinclusion body
C0016020cellular_componentmembrane
C0031595cellular_componentnuclear proteasome complex
C0005654cellular_componentnucleoplasm
C0005634cellular_componentnucleus
C0098794cellular_componentpostsynapse
C0022624cellular_componentproteasome accessory complex
C0000502cellular_componentproteasome complex
C0008540cellular_componentproteasome regulatory particle, base subcomplex
C0005524molecular_functionATP binding
C0016887molecular_functionATPase activity
C0017025molecular_functionTBP-class protein binding
C0031531molecular_functionthyrotropin-releasing hormone receptor binding
C0008134molecular_functiontranscription factor binding
C0031145biological_processanaphase-promoting complex-dependent catabolic process
C0002479biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
C0038095biological_processFc-epsilon receptor signaling pathway
C0070498biological_processinterleukin-1-mediated signaling pathway
C0000165biological_processMAPK cascade
C0050804biological_processmodulation of chemical synaptic transmission
C0090090biological_processnegative regulation of canonical Wnt signaling pathway
C0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
C0043069biological_processnegative regulation of programmed cell death
C0045892biological_processnegative regulation of transcription, DNA-templated
C0038061biological_processNIK/NF-kappaB signaling
C0090263biological_processpositive regulation of canonical Wnt signaling pathway
C0090261biological_processpositive regulation of inclusion body assembly
C0045899biological_processpositive regulation of RNA polymerase II transcriptional preinitiation complex assembly
C0045893biological_processpositive regulation of transcription, DNA-templated
C0043687biological_processpost-translational protein modification
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0016579biological_processprotein deubiquitination
C0000209biological_processprotein polyubiquitination
C0006521biological_processregulation of cellular amino acid metabolic process
C1902036biological_processregulation of hematopoietic stem cell differentiation
C1901990biological_processregulation of mitotic cell cycle phase transition
C0043488biological_processregulation of mRNA stability
C0006357biological_processregulation of transcription by RNA polymerase II
C0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
C0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C0002223biological_processstimulatory C-type lectin receptor signaling pathway
C0050852biological_processT cell receptor signaling pathway
C0055085biological_processtransmembrane transport
C0033209biological_processtumor necrosis factor-mediated signaling pathway
C0060071biological_processWnt signaling pathway, planar cell polarity pathway
L0005813cellular_componentcentrosome
L0005737cellular_componentcytoplasm
L0005829cellular_componentcytosol
L0070062cellular_componentextracellular exosome
L0005654cellular_componentnucleoplasm
L0005634cellular_componentnucleus
L0005844cellular_componentpolysome
L0000502cellular_componentproteasome complex
L0005839cellular_componentproteasome core complex
L0019773cellular_componentproteasome core complex, alpha-subunit complex
L0004175molecular_functionendopeptidase activity
L0001530molecular_functionlipopolysaccharide binding
L0003723molecular_functionRNA binding
L0004298molecular_functionthreonine-type endopeptidase activity
L0031145biological_processanaphase-promoting complex-dependent catabolic process
L0002479biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
L0038095biological_processFc-epsilon receptor signaling pathway
L0070498biological_processinterleukin-1-mediated signaling pathway
L0000165biological_processMAPK cascade
L0090090biological_processnegative regulation of canonical Wnt signaling pathway
L0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
L0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
L0038061biological_processNIK/NF-kappaB signaling
L0090263biological_processpositive regulation of canonical Wnt signaling pathway
L0043687biological_processpost-translational protein modification
L0010498biological_processproteasomal protein catabolic process
L0010499biological_processproteasomal ubiquitin-independent protein catabolic process
L0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
L0016579biological_processprotein deubiquitination
L0000209biological_processprotein polyubiquitination
L0006521biological_processregulation of cellular amino acid metabolic process
L1902036biological_processregulation of hematopoietic stem cell differentiation
L1901990biological_processregulation of mitotic cell cycle phase transition
L0043488biological_processregulation of mRNA stability
L0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
L0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
L0002223biological_processstimulatory C-type lectin receptor signaling pathway
L0050852biological_processT cell receptor signaling pathway
L0055085biological_processtransmembrane transport
L0033209biological_processtumor necrosis factor-mediated signaling pathway
L0060071biological_processWnt signaling pathway, planar cell polarity pathway
l0005813cellular_componentcentrosome
l0005737cellular_componentcytoplasm
l0005829cellular_componentcytosol
l0070062cellular_componentextracellular exosome
l0005654cellular_componentnucleoplasm
l0005634cellular_componentnucleus
l0005844cellular_componentpolysome
l0000502cellular_componentproteasome complex
l0005839cellular_componentproteasome core complex
l0019773cellular_componentproteasome core complex, alpha-subunit complex
l0004175molecular_functionendopeptidase activity
l0001530molecular_functionlipopolysaccharide binding
l0003723molecular_functionRNA binding
l0004298molecular_functionthreonine-type endopeptidase activity
l0031145biological_processanaphase-promoting complex-dependent catabolic process
l0002479biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
l0038095biological_processFc-epsilon receptor signaling pathway
l0070498biological_processinterleukin-1-mediated signaling pathway
l0000165biological_processMAPK cascade
l0090090biological_processnegative regulation of canonical Wnt signaling pathway
l0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
l0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
l0038061biological_processNIK/NF-kappaB signaling
l0090263biological_processpositive regulation of canonical Wnt signaling pathway
l0043687biological_processpost-translational protein modification
l0010498biological_processproteasomal protein catabolic process
l0010499biological_processproteasomal ubiquitin-independent protein catabolic process
l0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
l0016579biological_processprotein deubiquitination
l0000209biological_processprotein polyubiquitination
l0006521biological_processregulation of cellular amino acid metabolic process
l1902036biological_processregulation of hematopoietic stem cell differentiation
l1901990biological_processregulation of mitotic cell cycle phase transition
l0043488biological_processregulation of mRNA stability
l0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
l0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
l0002223biological_processstimulatory C-type lectin receptor signaling pathway
l0050852biological_processT cell receptor signaling pathway
l0055085biological_processtransmembrane transport
l0033209biological_processtumor necrosis factor-mediated signaling pathway
l0060071biological_processWnt signaling pathway, planar cell polarity pathway
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0070062cellular_componentextracellular exosome
H0005576cellular_componentextracellular region
H1904813cellular_componentficolin-1-rich granule lumen
H0005654cellular_componentnucleoplasm
H0005634cellular_componentnucleus
H0000932cellular_componentP-body
H0000502cellular_componentproteasome complex
H0005839cellular_componentproteasome core complex
H0019773cellular_componentproteasome core complex, alpha-subunit complex
H0034774cellular_componentsecretory granule lumen
H0004175molecular_functionendopeptidase activity
H0004298molecular_functionthreonine-type endopeptidase activity
H0031145biological_processanaphase-promoting complex-dependent catabolic process
H0002479biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
H0038095biological_processFc-epsilon receptor signaling pathway
H0070498biological_processinterleukin-1-mediated signaling pathway
H0000165biological_processMAPK cascade
H0090090biological_processnegative regulation of canonical Wnt signaling pathway
H0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
H0043312biological_processneutrophil degranulation
H0038061biological_processNIK/NF-kappaB signaling
H0090263biological_processpositive regulation of canonical Wnt signaling pathway
H0043687biological_processpost-translational protein modification
H0010498biological_processproteasomal protein catabolic process
H0010499biological_processproteasomal ubiquitin-independent protein catabolic process
H0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
H0016579biological_processprotein deubiquitination
H0000209biological_processprotein polyubiquitination
H0006521biological_processregulation of cellular amino acid metabolic process
H1902036biological_processregulation of hematopoietic stem cell differentiation
H1901990biological_processregulation of mitotic cell cycle phase transition
H0043488biological_processregulation of mRNA stability
H0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
H0009615biological_processresponse to virus
H0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
H0002223biological_processstimulatory C-type lectin receptor signaling pathway
H0050852biological_processT cell receptor signaling pathway
H0055085biological_processtransmembrane transport
H0033209biological_processtumor necrosis factor-mediated signaling pathway
H0060071biological_processWnt signaling pathway, planar cell polarity pathway
h0005737cellular_componentcytoplasm
h0005829cellular_componentcytosol
h0070062cellular_componentextracellular exosome
h0005576cellular_componentextracellular region
h1904813cellular_componentficolin-1-rich granule lumen
h0005654cellular_componentnucleoplasm
h0005634cellular_componentnucleus
h0000932cellular_componentP-body
h0000502cellular_componentproteasome complex
h0005839cellular_componentproteasome core complex
h0019773cellular_componentproteasome core complex, alpha-subunit complex
h0034774cellular_componentsecretory granule lumen
h0004175molecular_functionendopeptidase activity
h0004298molecular_functionthreonine-type endopeptidase activity
h0031145biological_processanaphase-promoting complex-dependent catabolic process
h0002479biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
h0038095biological_processFc-epsilon receptor signaling pathway
h0070498biological_processinterleukin-1-mediated signaling pathway
h0000165biological_processMAPK cascade
h0090090biological_processnegative regulation of canonical Wnt signaling pathway
h0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
h0043312biological_processneutrophil degranulation
h0038061biological_processNIK/NF-kappaB signaling
h0090263biological_processpositive regulation of canonical Wnt signaling pathway
h0043687biological_processpost-translational protein modification
h0010498biological_processproteasomal protein catabolic process
h0010499biological_processproteasomal ubiquitin-independent protein catabolic process
h0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
h0016579biological_processprotein deubiquitination
h0000209biological_processprotein polyubiquitination
h0006521biological_processregulation of cellular amino acid metabolic process
h1902036biological_processregulation of hematopoietic stem cell differentiation
h1901990biological_processregulation of mitotic cell cycle phase transition
h0043488biological_processregulation of mRNA stability
h0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
h0009615biological_processresponse to virus
h0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
h0002223biological_processstimulatory C-type lectin receptor signaling pathway
h0050852biological_processT cell receptor signaling pathway
h0055085biological_processtransmembrane transport
h0033209biological_processtumor necrosis factor-mediated signaling pathway
h0060071biological_processWnt signaling pathway, planar cell polarity pathway
M0005737cellular_componentcytoplasm
M0005829cellular_componentcytosol
M0070062cellular_componentextracellular exosome
M0005654cellular_componentnucleoplasm
M0005634cellular_componentnucleus
M0000502cellular_componentproteasome complex
M0005839cellular_componentproteasome core complex
M0019773cellular_componentproteasome core complex, alpha-subunit complex
M0045202cellular_componentsynapse
M0004175molecular_functionendopeptidase activity
M0004298molecular_functionthreonine-type endopeptidase activity
M0031625molecular_functionubiquitin protein ligase binding
M0031145biological_processanaphase-promoting complex-dependent catabolic process
M0002479biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
M0038095biological_processFc-epsilon receptor signaling pathway
M0070498biological_processinterleukin-1-mediated signaling pathway
M0000165biological_processMAPK cascade
M0090090biological_processnegative regulation of canonical Wnt signaling pathway
M0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
M0038061biological_processNIK/NF-kappaB signaling
M0090263biological_processpositive regulation of canonical Wnt signaling pathway
M0043687biological_processpost-translational protein modification
M0010498biological_processproteasomal protein catabolic process
M0010499biological_processproteasomal ubiquitin-independent protein catabolic process
M0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
M0016579biological_processprotein deubiquitination
M0000209biological_processprotein polyubiquitination
M0006521biological_processregulation of cellular amino acid metabolic process
M0052548biological_processregulation of endopeptidase activity
M1902036biological_processregulation of hematopoietic stem cell differentiation
M1901990biological_processregulation of mitotic cell cycle phase transition
M0043488biological_processregulation of mRNA stability
M0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
M0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
M0002223biological_processstimulatory C-type lectin receptor signaling pathway
M0050852biological_processT cell receptor signaling pathway
M0055085biological_processtransmembrane transport
M0033209biological_processtumor necrosis factor-mediated signaling pathway
M0016032biological_processviral process
M0060071biological_processWnt signaling pathway, planar cell polarity pathway
m0005737cellular_componentcytoplasm
m0005829cellular_componentcytosol
m0070062cellular_componentextracellular exosome
m0005654cellular_componentnucleoplasm
m0005634cellular_componentnucleus
m0000502cellular_componentproteasome complex
m0005839cellular_componentproteasome core complex
m0019773cellular_componentproteasome core complex, alpha-subunit complex
m0045202cellular_componentsynapse
m0004175molecular_functionendopeptidase activity
m0004298molecular_functionthreonine-type endopeptidase activity
m0031625molecular_functionubiquitin protein ligase binding
m0031145biological_processanaphase-promoting complex-dependent catabolic process
m0002479biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
m0038095biological_processFc-epsilon receptor signaling pathway
m0070498biological_processinterleukin-1-mediated signaling pathway
m0000165biological_processMAPK cascade
m0090090biological_processnegative regulation of canonical Wnt signaling pathway
m0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
m0038061biological_processNIK/NF-kappaB signaling
m0090263biological_processpositive regulation of canonical Wnt signaling pathway
m0043687biological_processpost-translational protein modification
m0010498biological_processproteasomal protein catabolic process
m0010499biological_processproteasomal ubiquitin-independent protein catabolic process
m0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
m0016579biological_processprotein deubiquitination
m0000209biological_processprotein polyubiquitination
m0006521biological_processregulation of cellular amino acid metabolic process
m0052548biological_processregulation of endopeptidase activity
m1902036biological_processregulation of hematopoietic stem cell differentiation
m1901990biological_processregulation of mitotic cell cycle phase transition
m0043488biological_processregulation of mRNA stability
m0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
m0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
m0002223biological_processstimulatory C-type lectin receptor signaling pathway
m0050852biological_processT cell receptor signaling pathway
m0055085biological_processtransmembrane transport
m0033209biological_processtumor necrosis factor-mediated signaling pathway
m0016032biological_processviral process
m0060071biological_processWnt signaling pathway, planar cell polarity pathway
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0070062cellular_componentextracellular exosome
I0043231cellular_componentintracellular membrane-bounded organelle
I0005654cellular_componentnucleoplasm
I0005634cellular_componentnucleus
I0000932cellular_componentP-body
I0000502cellular_componentproteasome complex
I0005839cellular_componentproteasome core complex
I0019773cellular_componentproteasome core complex, alpha-subunit complex
I0004175molecular_functionendopeptidase activity
I0004298molecular_functionthreonine-type endopeptidase activity
I0031145biological_processanaphase-promoting complex-dependent catabolic process
I0002479biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
I0038095biological_processFc-epsilon receptor signaling pathway
I0070498biological_processinterleukin-1-mediated signaling pathway
I0000165biological_processMAPK cascade
I0090090biological_processnegative regulation of canonical Wnt signaling pathway
I0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
I0038061biological_processNIK/NF-kappaB signaling
I0090263biological_processpositive regulation of canonical Wnt signaling pathway
I0043687biological_processpost-translational protein modification
I0010498biological_processproteasomal protein catabolic process
I0010499biological_processproteasomal ubiquitin-independent protein catabolic process
I0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
I0016579biological_processprotein deubiquitination
I0000209biological_processprotein polyubiquitination
I0006521biological_processregulation of cellular amino acid metabolic process
I1902036biological_processregulation of hematopoietic stem cell differentiation
I1901990biological_processregulation of mitotic cell cycle phase transition
I0043488biological_processregulation of mRNA stability
I0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
I0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
I0002223biological_processstimulatory C-type lectin receptor signaling pathway
I0050852biological_processT cell receptor signaling pathway
I0055085biological_processtransmembrane transport
I0033209biological_processtumor necrosis factor-mediated signaling pathway
I0016032biological_processviral process
I0060071biological_processWnt signaling pathway, planar cell polarity pathway
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c0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
c0045471biological_processresponse to ethanol
c0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
c0002223biological_processstimulatory C-type lectin receptor signaling pathway
c0050852biological_processT cell receptor signaling pathway
c0055085biological_processtransmembrane transport
c0033209biological_processtumor necrosis factor-mediated signaling pathway
c0006511biological_processubiquitin-dependent protein catabolic process
c0060071biological_processWnt signaling pathway, planar cell polarity pathway
U0035578cellular_componentazurophil granule lumen
U0005829cellular_componentcytosol
U0005576cellular_componentextracellular region
U0016020cellular_componentmembrane
U0005654cellular_componentnucleoplasm
U0005634cellular_componentnucleus
U0022624cellular_componentproteasome accessory complex
U0000502cellular_componentproteasome complex
U0005838cellular_componentproteasome regulatory particle
U0008540cellular_componentproteasome regulatory particle, base subcomplex
U0034515cellular_componentproteasome storage granule
U0030234molecular_functionenzyme regulator activity
U0031625molecular_functionubiquitin protein ligase binding
U0031145biological_processanaphase-promoting complex-dependent catabolic process
U0002479biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
U0038095biological_processFc-epsilon receptor signaling pathway
U0070498biological_processinterleukin-1-mediated signaling pathway
U0000165biological_processMAPK cascade
U0090090biological_processnegative regulation of canonical Wnt signaling pathway
U0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
U0043312biological_processneutrophil degranulation
U0038061biological_processNIK/NF-kappaB signaling
U0090263biological_processpositive regulation of canonical Wnt signaling pathway
U0043687biological_processpost-translational protein modification
U0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
U0016579biological_processprotein deubiquitination
U0000209biological_processprotein polyubiquitination
U0006521biological_processregulation of cellular amino acid metabolic process
U1902036biological_processregulation of hematopoietic stem cell differentiation
U1901990biological_processregulation of mitotic cell cycle phase transition
U0043488biological_processregulation of mRNA stability
U0042176biological_processregulation of protein catabolic process
U0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
U0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
U0002223biological_processstimulatory C-type lectin receptor signaling pathway
U0050852biological_processT cell receptor signaling pathway
U0055085biological_processtransmembrane transport
U0033209biological_processtumor necrosis factor-mediated signaling pathway
U0060071biological_processWnt signaling pathway, planar cell polarity pathway
f0005829cellular_componentcytosol
f0070062cellular_componentextracellular exosome
f0005576cellular_componentextracellular region
f1904813cellular_componentficolin-1-rich granule lumen
f0016020cellular_componentmembrane
f0005654cellular_componentnucleoplasm
f0005634cellular_componentnucleus
f0022624cellular_componentproteasome accessory complex
f0000502cellular_componentproteasome complex
f0005838cellular_componentproteasome regulatory particle
f0008540cellular_componentproteasome regulatory particle, base subcomplex
f0034515cellular_componentproteasome storage granule
f0034774cellular_componentsecretory granule lumen
f0030234molecular_functionenzyme regulator activity
f0031145biological_processanaphase-promoting complex-dependent catabolic process
f0002479biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
f0038095biological_processFc-epsilon receptor signaling pathway
f0070498biological_processinterleukin-1-mediated signaling pathway
f0000165biological_processMAPK cascade
f0090090biological_processnegative regulation of canonical Wnt signaling pathway
f0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
f0043312biological_processneutrophil degranulation
f0038061biological_processNIK/NF-kappaB signaling
f0090263biological_processpositive regulation of canonical Wnt signaling pathway
f0043687biological_processpost-translational protein modification
f0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
f0016579biological_processprotein deubiquitination
f0000209biological_processprotein polyubiquitination
f0006521biological_processregulation of cellular amino acid metabolic process
f1902036biological_processregulation of hematopoietic stem cell differentiation
f1901990biological_processregulation of mitotic cell cycle phase transition
f0043488biological_processregulation of mRNA stability
f0042176biological_processregulation of protein catabolic process
f0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
f0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
f0002223biological_processstimulatory C-type lectin receptor signaling pathway
f0050852biological_processT cell receptor signaling pathway
f0055085biological_processtransmembrane transport
f0033209biological_processtumor necrosis factor-mediated signaling pathway
f0060071biological_processWnt signaling pathway, planar cell polarity pathway
V0005829cellular_componentcytosol
V0070062cellular_componentextracellular exosome
V0005576cellular_componentextracellular region
V1904813cellular_componentficolin-1-rich granule lumen
V0016020cellular_componentmembrane
V0005654cellular_componentnucleoplasm
V0005634cellular_componentnucleus
V0022624cellular_componentproteasome accessory complex
V0000502cellular_componentproteasome complex
V0008541cellular_componentproteasome regulatory particle, lid subcomplex
V0034774cellular_componentsecretory granule lumen
V0030234molecular_functionenzyme regulator activity
V0031145biological_processanaphase-promoting complex-dependent catabolic process
V0002479biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
V0038095biological_processFc-epsilon receptor signaling pathway
V0070498biological_processinterleukin-1-mediated signaling pathway
V0000165biological_processMAPK cascade
V0090090biological_processnegative regulation of canonical Wnt signaling pathway
V0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
V0043312biological_processneutrophil degranulation
V0038061biological_processNIK/NF-kappaB signaling
V0090263biological_processpositive regulation of canonical Wnt signaling pathway
V0043687biological_processpost-translational protein modification
V0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
V0016579biological_processprotein deubiquitination
V0000209biological_processprotein polyubiquitination
V0006521biological_processregulation of cellular amino acid metabolic process
V1902036biological_processregulation of hematopoietic stem cell differentiation
V1901990biological_processregulation of mitotic cell cycle phase transition
V0043488biological_processregulation of mRNA stability
V0042176biological_processregulation of protein catabolic process
V0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
V0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
V0002223biological_processstimulatory C-type lectin receptor signaling pathway
V0050852biological_processT cell receptor signaling pathway
V0055085biological_processtransmembrane transport
V0033209biological_processtumor necrosis factor-mediated signaling pathway
V0006511biological_processubiquitin-dependent protein catabolic process
V0060071biological_processWnt signaling pathway, planar cell polarity pathway
b0005829cellular_componentcytosol
b0005654cellular_componentnucleoplasm
b0005634cellular_componentnucleus
b0022624cellular_componentproteasome accessory complex
b0000502cellular_componentproteasome complex
b0008540cellular_componentproteasome regulatory particle, base subcomplex
b0042802molecular_functionidentical protein binding
b0031593molecular_functionpolyubiquitin modification-dependent protein binding
b0003723molecular_functionRNA binding
b0031145biological_processanaphase-promoting complex-dependent catabolic process
b0002479biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
b0038095biological_processFc-epsilon receptor signaling pathway
b0070498biological_processinterleukin-1-mediated signaling pathway
b0000165biological_processMAPK cascade
b0090090biological_processnegative regulation of canonical Wnt signaling pathway
b0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
b0038061biological_processNIK/NF-kappaB signaling
b0090263biological_processpositive regulation of canonical Wnt signaling pathway
b0043687biological_processpost-translational protein modification
b0043248biological_processproteasome assembly
b0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
b0016579biological_processprotein deubiquitination
b0000209biological_processprotein polyubiquitination
b0006521biological_processregulation of cellular amino acid metabolic process
b1902036biological_processregulation of hematopoietic stem cell differentiation
b1901990biological_processregulation of mitotic cell cycle phase transition
b0043488biological_processregulation of mRNA stability
b0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
b0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
b0002223biological_processstimulatory C-type lectin receptor signaling pathway
b0050852biological_processT cell receptor signaling pathway
b0055085biological_processtransmembrane transport
b0033209biological_processtumor necrosis factor-mediated signaling pathway
b0060071biological_processWnt signaling pathway, planar cell polarity pathway
Y0005829cellular_componentcytosol
Y0005576cellular_componentextracellular region
Y1904813cellular_componentficolin-1-rich granule lumen
Y0005654cellular_componentnucleoplasm
Y0022624cellular_componentproteasome accessory complex
Y0000502cellular_componentproteasome complex
Y0005838cellular_componentproteasome regulatory particle
Y0034774cellular_componentsecretory granule lumen
Y0016887molecular_functionATPase activity
Y0030234molecular_functionenzyme regulator activity
Y0031145biological_processanaphase-promoting complex-dependent catabolic process
Y0002479biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
Y0038095biological_processFc-epsilon receptor signaling pathway
Y0070498biological_processinterleukin-1-mediated signaling pathway
Y0000165biological_processMAPK cascade
Y0090090biological_processnegative regulation of canonical Wnt signaling pathway
Y0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
Y0043312biological_processneutrophil degranulation
Y0038061biological_processNIK/NF-kappaB signaling
Y0090263biological_processpositive regulation of canonical Wnt signaling pathway
Y0043687biological_processpost-translational protein modification
Y0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Y0016579biological_processprotein deubiquitination
Y0000209biological_processprotein polyubiquitination
Y0006508biological_processproteolysis
Y0006521biological_processregulation of cellular amino acid metabolic process
Y1902036biological_processregulation of hematopoietic stem cell differentiation
Y1901990biological_processregulation of mitotic cell cycle phase transition
Y0043488biological_processregulation of mRNA stability
Y0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
Y0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Y0002223biological_processstimulatory C-type lectin receptor signaling pathway
Y0050852biological_processT cell receptor signaling pathway
Y0055085biological_processtransmembrane transport
Y0033209biological_processtumor necrosis factor-mediated signaling pathway
Y0060071biological_processWnt signaling pathway, planar cell polarity pathway
Z0005829cellular_componentcytosol
Z0070062cellular_componentextracellular exosome
Z0005576cellular_componentextracellular region
Z1904813cellular_componentficolin-1-rich granule lumen
Z0016020cellular_componentmembrane
Z0005654cellular_componentnucleoplasm
Z0005634cellular_componentnucleus
Z0000502cellular_componentproteasome complex
Z0005838cellular_componentproteasome regulatory particle
Z0034774cellular_componentsecretory granule lumen
Z0042803molecular_functionprotein homodimerization activity
Z0031145biological_processanaphase-promoting complex-dependent catabolic process
Z0002479biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
Z0038095biological_processFc-epsilon receptor signaling pathway
Z0070498biological_processinterleukin-1-mediated signaling pathway
Z0000165biological_processMAPK cascade
Z0090090biological_processnegative regulation of canonical Wnt signaling pathway
Z0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
Z0043312biological_processneutrophil degranulation
Z0038061biological_processNIK/NF-kappaB signaling
Z0090263biological_processpositive regulation of canonical Wnt signaling pathway
Z0043687biological_processpost-translational protein modification
Z0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Z0016579biological_processprotein deubiquitination
Z0000209biological_processprotein polyubiquitination
Z0006521biological_processregulation of cellular amino acid metabolic process
Z1902036biological_processregulation of hematopoietic stem cell differentiation
Z1901990biological_processregulation of mitotic cell cycle phase transition
Z0043488biological_processregulation of mRNA stability
Z0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
Z0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Z0002223biological_processstimulatory C-type lectin receptor signaling pathway
Z0050852biological_processT cell receptor signaling pathway
Z0055085biological_processtransmembrane transport
Z0033209biological_processtumor necrosis factor-mediated signaling pathway
Z0060071biological_processWnt signaling pathway, planar cell polarity pathway
d0005829cellular_componentcytosol
d0005654cellular_componentnucleoplasm
d0005634cellular_componentnucleus
d0022624cellular_componentproteasome accessory complex
d0000502cellular_componentproteasome complex
d0005838cellular_componentproteasome regulatory particle
d0008541cellular_componentproteasome regulatory particle, lid subcomplex
d0031145biological_processanaphase-promoting complex-dependent catabolic process
d0002479biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
d0038095biological_processFc-epsilon receptor signaling pathway
d0070498biological_processinterleukin-1-mediated signaling pathway
d0000165biological_processMAPK cascade
d0090090biological_processnegative regulation of canonical Wnt signaling pathway
d0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
d0038061biological_processNIK/NF-kappaB signaling
d0090263biological_processpositive regulation of canonical Wnt signaling pathway
d0043687biological_processpost-translational protein modification
d0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
d0016579biological_processprotein deubiquitination
d0000209biological_processprotein polyubiquitination
d0006521biological_processregulation of cellular amino acid metabolic process
d1902036biological_processregulation of hematopoietic stem cell differentiation
d1901990biological_processregulation of mitotic cell cycle phase transition
d0043488biological_processregulation of mRNA stability
d0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
d0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
d0002223biological_processstimulatory C-type lectin receptor signaling pathway
d0050852biological_processT cell receptor signaling pathway
d0055085biological_processtransmembrane transport
d0033209biological_processtumor necrosis factor-mediated signaling pathway
d0060071biological_processWnt signaling pathway, planar cell polarity pathway
e0005829cellular_componentcytosol
e0005654cellular_componentnucleoplasm
e0000502cellular_componentproteasome complex
e0008541cellular_componentproteasome regulatory particle, lid subcomplex
e0031145biological_processanaphase-promoting complex-dependent catabolic process
e0002479biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
e0038095biological_processFc-epsilon receptor signaling pathway
e0070498biological_processinterleukin-1-mediated signaling pathway
e0000165biological_processMAPK cascade
e0006406biological_processmRNA export from nucleus
e0090090biological_processnegative regulation of canonical Wnt signaling pathway
e0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
e0038061biological_processNIK/NF-kappaB signaling
e0090263biological_processpositive regulation of canonical Wnt signaling pathway
e0043687biological_processpost-translational protein modification
e0043248biological_processproteasome assembly
e0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
e0016579biological_processprotein deubiquitination
e0000209biological_processprotein polyubiquitination
e0006521biological_processregulation of cellular amino acid metabolic process
e1902036biological_processregulation of hematopoietic stem cell differentiation
e1901990biological_processregulation of mitotic cell cycle phase transition
e0043488biological_processregulation of mRNA stability
e0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
e0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
e0002223biological_processstimulatory C-type lectin receptor signaling pathway
e0050852biological_processT cell receptor signaling pathway
e0055085biological_processtransmembrane transport
e0033209biological_processtumor necrosis factor-mediated signaling pathway
e0060071biological_processWnt signaling pathway, planar cell polarity pathway
u0005737cellular_componentcytoplasm
u0005829cellular_componentcytosol
u0030666cellular_componentendocytic vesicle membrane
u0005789cellular_componentendoplasmic reticulum membrane
u0010008cellular_componentendosome membrane
u0070062cellular_componentextracellular exosome
u0005615cellular_componentextracellular space
u0043657cellular_componenthost cell
u0005741cellular_componentmitochondrial outer membrane
u0005739cellular_componentmitochondrion
u0043005cellular_componentneuron projection
u0043025cellular_componentneuronal cell body
u0005654cellular_componentnucleoplasm
u0005634cellular_componentnucleus
u0005886cellular_componentplasma membrane
u0031982cellular_componentvesicle
u0031386molecular_functionprotein tag
u0031625molecular_functionubiquitin protein ligase binding
u0000187biological_processactivation of MAPK activity
u0031145biological_processanaphase-promoting complex-dependent catabolic process
u0044267biological_processcellular protein metabolic process
u0019221biological_processcytokine-mediated signaling pathway
u0042769biological_processDNA damage response, detection of DNA damage
u0016197biological_processendosomal transport
u0097009biological_processenergy homeostasis
u0070987biological_processerror-free translesion synthesis
u0042276biological_processerror-prone translesion synthesis
u0060613biological_processfat pad development
u0008585biological_processfemale gonad development
u0007144biological_processfemale meiosis I
u0070911biological_processglobal genome nucleotide-excision repair
u0021888biological_processhypothalamus gonadotrophin-releasing hormone neuron development
u0007249biological_processI-kappaB kinase/NF-kappaB signaling
u0070498biological_processinterleukin-1-mediated signaling pathway
u0036297biological_processinterstrand cross-link repair
u0075733biological_processintracellular transport of virus
u0007254biological_processJNK cascade
u0007141biological_processmale meiosis I
u0061024biological_processmembrane organization
u0047497biological_processmitochondrion transport along microtubule
u0019941biological_processmodification-dependent protein catabolic process
u0002755biological_processMyD88-dependent toll-like receptor signaling pathway
u0002756biological_processMyD88-independent toll-like receptor signaling pathway
u0043066biological_processnegative regulation of apoptotic process
u0000122biological_processnegative regulation of transcription by RNA polymerase II
u0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
u0048812biological_processneuron projection morphogenesis
u0070423biological_processnucleotide-binding oligomerization domain containing signaling pathway
u0000715biological_processnucleotide-excision repair, DNA damage recognition
u0000717biological_processnucleotide-excision repair, DNA duplex unwinding
u0006297biological_processnucleotide-excision repair, DNA gap filling
u0033683biological_processnucleotide-excision repair, DNA incision
u0006296biological_processnucleotide-excision repair, DNA incision, 5'-to lesion
u0006294biological_processnucleotide-excision repair, preincision complex assembly
u0043065biological_processpositive regulation of apoptotic process
u1902255biological_processpositive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
u0051092biological_processpositive regulation of NF-kappaB transcription factor activity
u1902527biological_processpositive regulation of protein monoubiquitination
u0031398biological_processpositive regulation of protein ubiquitination
u0045944biological_processpositive regulation of transcription by RNA polymerase II
u0016579biological_processprotein deubiquitination
u0000209biological_processprotein polyubiquitination
u0006625biological_processprotein targeting to peroxisome
u0016567biological_processprotein ubiquitination
u0051881biological_processregulation of mitochondrial membrane potential
u0043488biological_processregulation of mRNA stability
u1901214biological_processregulation of neuron death
u0061136biological_processregulation of proteasomal protein catabolic process
u0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
u0072520biological_processseminiferous tubule development
u0051403biological_processstress-activated MAPK cascade
u0006283biological_processtranscription-coupled nucleotide-excision repair
u0007179biological_processtransforming growth factor beta receptor signaling pathway
u0019985biological_processtranslesion synthesis
u0055085biological_processtransmembrane transport
u0035666biological_processTRIF-dependent toll-like receptor signaling pathway
u0019058biological_processviral life cycle
u0019068biological_processvirion assembly
u0016055biological_processWnt signaling pathway
w0005737cellular_componentcytoplasm
w0005829cellular_componentcytosol
w0030666cellular_componentendocytic vesicle membrane
w0005789cellular_componentendoplasmic reticulum membrane
w0010008cellular_componentendosome membrane
w0070062cellular_componentextracellular exosome
w0005615cellular_componentextracellular space
w0043657cellular_componenthost cell
w0005741cellular_componentmitochondrial outer membrane
w0005739cellular_componentmitochondrion
w0043005cellular_componentneuron projection
w0043025cellular_componentneuronal cell body
w0005654cellular_componentnucleoplasm
w0005634cellular_componentnucleus
w0005886cellular_componentplasma membrane
w0031982cellular_componentvesicle
w0031386molecular_functionprotein tag
w0031625molecular_functionubiquitin protein ligase binding
w0000187biological_processactivation of MAPK activity
w0031145biological_processanaphase-promoting complex-dependent catabolic process
w0044267biological_processcellular protein metabolic process
w0019221biological_processcytokine-mediated signaling pathway
w0042769biological_processDNA damage response, detection of DNA damage
w0016197biological_processendosomal transport
w0097009biological_processenergy homeostasis
w0070987biological_processerror-free translesion synthesis
w0042276biological_processerror-prone translesion synthesis
w0060613biological_processfat pad development
w0008585biological_processfemale gonad development
w0007144biological_processfemale meiosis I
w0070911biological_processglobal genome nucleotide-excision repair
w0021888biological_processhypothalamus gonadotrophin-releasing hormone neuron development
w0007249biological_processI-kappaB kinase/NF-kappaB signaling
w0070498biological_processinterleukin-1-mediated signaling pathway
w0036297biological_processinterstrand cross-link repair
w0075733biological_processintracellular transport of virus
w0007254biological_processJNK cascade
w0007141biological_processmale meiosis I
w0061024biological_processmembrane organization
w0047497biological_processmitochondrion transport along microtubule
w0019941biological_processmodification-dependent protein catabolic process
w0002755biological_processMyD88-dependent toll-like receptor signaling pathway
w0002756biological_processMyD88-independent toll-like receptor signaling pathway
w0043066biological_processnegative regulation of apoptotic process
w0000122biological_processnegative regulation of transcription by RNA polymerase II
w0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
w0048812biological_processneuron projection morphogenesis
w0070423biological_processnucleotide-binding oligomerization domain containing signaling pathway
w0000715biological_processnucleotide-excision repair, DNA damage recognition
w0000717biological_processnucleotide-excision repair, DNA duplex unwinding
w0006297biological_processnucleotide-excision repair, DNA gap filling
w0033683biological_processnucleotide-excision repair, DNA incision
w0006296biological_processnucleotide-excision repair, DNA incision, 5'-to lesion
w0006294biological_processnucleotide-excision repair, preincision complex assembly
w0043065biological_processpositive regulation of apoptotic process
w1902255biological_processpositive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
w0051092biological_processpositive regulation of NF-kappaB transcription factor activity
w1902527biological_processpositive regulation of protein monoubiquitination
w0031398biological_processpositive regulation of protein ubiquitination
w0045944biological_processpositive regulation of transcription by RNA polymerase II
w0016579biological_processprotein deubiquitination
w0000209biological_processprotein polyubiquitination
w0006625biological_processprotein targeting to peroxisome
w0016567biological_processprotein ubiquitination
w0051881biological_processregulation of mitochondrial membrane potential
w0043488biological_processregulation of mRNA stability
w1901214biological_processregulation of neuron death
w0061136biological_processregulation of proteasomal protein catabolic process
w0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
w0072520biological_processseminiferous tubule development
w0051403biological_processstress-activated MAPK cascade
w0006283biological_processtranscription-coupled nucleotide-excision repair
w0007179biological_processtransforming growth factor beta receptor signaling pathway
w0019985biological_processtranslesion synthesis
w0055085biological_processtransmembrane transport
w0035666biological_processTRIF-dependent toll-like receptor signaling pathway
w0019058biological_processviral life cycle
w0019068biological_processvirion assembly
w0016055biological_processWnt signaling pathway
?

Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC14binding site for residue ZN c 401
ChainResidue
cGLU52
cHIS113
cHIS115
cASP126

AC217binding site for residue ATP A 501
ChainResidue
AASP176
AGLY178
APRO218
AGLY219
ATHR220
AGLY221
ALYS222
ATHR223
ALEU224
AILE354
AHIS358
AGLY382
AALA383
AMG502
BASP317
BARG343
BARG346

AC32binding site for residue MG A 502
ChainResidue
ATHR223
AATP501

AC414binding site for residue ATP B 501
ChainResidue
BILE187
BPRO228
BGLY229
BTHR230
BGLY231
BLYS232
BTHR233
BLEU234
BHIS368
BGLY392
BALA393
BLYS396
BMG502
CARG307

AC52binding site for residue MG B 502
ChainResidue
BTHR233
BATP501

AC612binding site for residue ADP C 501
ChainResidue
CMET150
CGLY152
CPRO192
CGLY193
CTHR194
CGLY195
CLYS196
CTHR197
CLEU198
CILE328
CGLY356
CLYS360

AC715binding site for residue ATP D 501
ChainResidue
DILE167
DGLY168
DPRO208
DGLY209
DCYS210
DGLY211
DLYS212
DTHR213
DMET214
DGLY372
DALA373
DASN376
DMG502
EARG291
EARG294

AC82binding site for residue MG D 502
ChainResidue
DTHR213
DATP501

AC918binding site for residue ATP E 401
ChainResidue
EILE135
EGLY136
EPRO176
EGLY177
ETHR178
EGLY179
ELYS180
ETHR181
ELEU182
EGLU234
EASN280
EILE312
EHIS316
EGLY340
EALA341
EMG402
FARG344
FARG347

AD12binding site for residue MG E 402
ChainResidue
ETHR181
EATP401

AD213binding site for residue ADP F 501
ChainResidue
FGLY189
FPRO229
FGLY230
FTHR231
FGLY232
FLYS233
FTHR234
FLEU235
FILE365
FHIS369
FGLY393
FLYS397
FMG502

AD34binding site for residue MG F 502
ChainResidue
FTHR234
FASP286
FGLU287
FADP501

?

Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
ATP_6msd_A_50123ADENOSINE-5'-TRIPHOSPHATE binding site
ChainResidueligand
AASP176-GLY178ATP: ADENOSINE-5'-TRIPHOSPHATE
ACYS180ATP: ADENOSINE-5'-TRIPHOSPHATE
APRO217-LEU224ATP: ADENOSINE-5'-TRIPHOSPHATE
AGLU276ATP: ADENOSINE-5'-TRIPHOSPHATE
AASN322ATP: ADENOSINE-5'-TRIPHOSPHATE
AILE354ATP: ADENOSINE-5'-TRIPHOSPHATE
AILE357-HIS358ATP: ADENOSINE-5'-TRIPHOSPHATE
AGLY382-ALA383ATP: ADENOSINE-5'-TRIPHOSPHATE
AARG386ATP: ADENOSINE-5'-TRIPHOSPHATE
BASP317ATP: ADENOSINE-5'-TRIPHOSPHATE
BARG343ATP: ADENOSINE-5'-TRIPHOSPHATE
BARG346ATP: ADENOSINE-5'-TRIPHOSPHATE

ADP_6msd_F_50124ADENOSINE-5'-DIPHOSPHATE binding site
ChainResidueligand
AARG333ADP: ADENOSINE-5'-DIPHOSPHATE
AARG336ADP: ADENOSINE-5'-DIPHOSPHATE
FASP187-GLY189ADP: ADENOSINE-5'-DIPHOSPHATE
FLEU191ADP: ADENOSINE-5'-DIPHOSPHATE
FPRO228-LEU235ADP: ADENOSINE-5'-DIPHOSPHATE
FARG238ADP: ADENOSINE-5'-DIPHOSPHATE
FASP286-GLU287ADP: ADENOSINE-5'-DIPHOSPHATE
FASN333ADP: ADENOSINE-5'-DIPHOSPHATE
FILE365ADP: ADENOSINE-5'-DIPHOSPHATE
FILE368-HIS369ADP: ADENOSINE-5'-DIPHOSPHATE
FGLY393-ALA394ADP: ADENOSINE-5'-DIPHOSPHATE
FLYS397ADP: ADENOSINE-5'-DIPHOSPHATE

ATP_6msd_B_50122ADENOSINE-5'-TRIPHOSPHATE binding site
ChainResidueligand
BASP186-GLY188ATP: ADENOSINE-5'-TRIPHOSPHATE
BLEU190ATP: ADENOSINE-5'-TRIPHOSPHATE
BPRO227-LEU234ATP: ADENOSINE-5'-TRIPHOSPHATE
BASP285ATP: ADENOSINE-5'-TRIPHOSPHATE
BASN332ATP: ADENOSINE-5'-TRIPHOSPHATE
BILE364ATP: ADENOSINE-5'-TRIPHOSPHATE
BILE367-HIS368ATP: ADENOSINE-5'-TRIPHOSPHATE
BGLY392-ALA393ATP: ADENOSINE-5'-TRIPHOSPHATE
BLYS396ATP: ADENOSINE-5'-TRIPHOSPHATE
CARG307ATP: ADENOSINE-5'-TRIPHOSPHATE
CARG310ATP: ADENOSINE-5'-TRIPHOSPHATE

ADP_6msd_C_50117ADENOSINE-5'-DIPHOSPHATE binding site
ChainResidueligand
CMET150-GLY152ADP: ADENOSINE-5'-DIPHOSPHATE
CLEU154ADP: ADENOSINE-5'-DIPHOSPHATE
CPRO191-LEU198ADP: ADENOSINE-5'-DIPHOSPHATE
CASP249ADP: ADENOSINE-5'-DIPHOSPHATE
CILE328ADP: ADENOSINE-5'-DIPHOSPHATE
CGLY356-ALA357ADP: ADENOSINE-5'-DIPHOSPHATE
CLYS360ADP: ADENOSINE-5'-DIPHOSPHATE

ATP_6msd_D_50125ADENOSINE-5'-TRIPHOSPHATE binding site
ChainResidueligand
DASP166-GLY168ATP: ADENOSINE-5'-TRIPHOSPHATE
DMET170ATP: ADENOSINE-5'-TRIPHOSPHATE
DPRO207-LEU215ATP: ADENOSINE-5'-TRIPHOSPHATE
DASN312ATP: ADENOSINE-5'-TRIPHOSPHATE
DILE344ATP: ADENOSINE-5'-TRIPHOSPHATE
DTHR347-ILE348ATP: ADENOSINE-5'-TRIPHOSPHATE
DGLY372-ALA373ATP: ADENOSINE-5'-TRIPHOSPHATE
DASN376ATP: ADENOSINE-5'-TRIPHOSPHATE
EASP265ATP: ADENOSINE-5'-TRIPHOSPHATE
EALA288ATP: ADENOSINE-5'-TRIPHOSPHATE
EARG291ATP: ADENOSINE-5'-TRIPHOSPHATE
EGLY293-ARG294ATP: ADENOSINE-5'-TRIPHOSPHATE

ATP_6msd_E_40126ADENOSINE-5'-TRIPHOSPHATE binding site
ChainResidueligand
EGLU134-GLY136ATP: ADENOSINE-5'-TRIPHOSPHATE
ELEU138ATP: ADENOSINE-5'-TRIPHOSPHATE
EPRO175-LEU183ATP: ADENOSINE-5'-TRIPHOSPHATE
EGLU234ATP: ADENOSINE-5'-TRIPHOSPHATE
EASN280ATP: ADENOSINE-5'-TRIPHOSPHATE
EILE312ATP: ADENOSINE-5'-TRIPHOSPHATE
EILE315-HIS316ATP: ADENOSINE-5'-TRIPHOSPHATE
EGLY340-ALA341ATP: ADENOSINE-5'-TRIPHOSPHATE
EARG344ATP: ADENOSINE-5'-TRIPHOSPHATE
FASP318-GLY319ATP: ADENOSINE-5'-TRIPHOSPHATE
FALA341ATP: ADENOSINE-5'-TRIPHOSPHATE
FARG344ATP: ADENOSINE-5'-TRIPHOSPHATE
FARG347ATP: ADENOSINE-5'-TRIPHOSPHATE

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
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Catalytic Information from CSA

site_idNumber of ResiduesDetails