Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6MRG

FAAH bound to non covalent inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0004040	molecular_function	amidase activity
A	0005515	molecular_function	protein binding
A	0005543	molecular_function	phospholipid binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0006631	biological_process	fatty acid metabolic process
A	0008289	molecular_function	lipid binding
A	0009062	biological_process	fatty acid catabolic process
A	0016020	cellular_component	membrane
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016788	molecular_function	hydrolase activity, acting on ester bonds
A	0017064	molecular_function	fatty acid amide hydrolase activity
A	0031090	cellular_component	organelle membrane
A	0042802	molecular_function	identical protein binding
A	0045907	biological_process	positive regulation of vasoconstriction
A	0047372	molecular_function	acylglycerol lipase activity
A	0052651	biological_process	monoacylglycerol catabolic process
A	0098793	cellular_component	presynapse
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse
A	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
B	0000139	cellular_component	Golgi membrane
B	0004040	molecular_function	amidase activity
B	0005515	molecular_function	protein binding
B	0005543	molecular_function	phospholipid binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005794	cellular_component	Golgi apparatus
B	0006631	biological_process	fatty acid metabolic process
B	0008289	molecular_function	lipid binding
B	0009062	biological_process	fatty acid catabolic process
B	0016020	cellular_component	membrane
B	0016042	biological_process	lipid catabolic process
B	0016787	molecular_function	hydrolase activity
B	0016788	molecular_function	hydrolase activity, acting on ester bonds
B	0017064	molecular_function	fatty acid amide hydrolase activity
B	0031090	cellular_component	organelle membrane
B	0042802	molecular_function	identical protein binding
B	0045907	biological_process	positive regulation of vasoconstriction
B	0047372	molecular_function	acylglycerol lipase activity
B	0052651	biological_process	monoacylglycerol catabolic process
B	0098793	cellular_component	presynapse
B	0098794	cellular_component	postsynapse
B	0098978	cellular_component	glutamatergic synapse
B	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
C	0000139	cellular_component	Golgi membrane
C	0004040	molecular_function	amidase activity
C	0005515	molecular_function	protein binding
C	0005543	molecular_function	phospholipid binding
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005794	cellular_component	Golgi apparatus
C	0006631	biological_process	fatty acid metabolic process
C	0008289	molecular_function	lipid binding
C	0009062	biological_process	fatty acid catabolic process
C	0016020	cellular_component	membrane
C	0016042	biological_process	lipid catabolic process
C	0016787	molecular_function	hydrolase activity
C	0016788	molecular_function	hydrolase activity, acting on ester bonds
C	0017064	molecular_function	fatty acid amide hydrolase activity
C	0031090	cellular_component	organelle membrane
C	0042802	molecular_function	identical protein binding
C	0045907	biological_process	positive regulation of vasoconstriction
C	0047372	molecular_function	acylglycerol lipase activity
C	0052651	biological_process	monoacylglycerol catabolic process
C	0098793	cellular_component	presynapse
C	0098794	cellular_component	postsynapse
C	0098978	cellular_component	glutamatergic synapse
C	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
D	0000139	cellular_component	Golgi membrane
D	0004040	molecular_function	amidase activity
D	0005515	molecular_function	protein binding
D	0005543	molecular_function	phospholipid binding
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005794	cellular_component	Golgi apparatus
D	0006631	biological_process	fatty acid metabolic process
D	0008289	molecular_function	lipid binding
D	0009062	biological_process	fatty acid catabolic process
D	0016020	cellular_component	membrane
D	0016042	biological_process	lipid catabolic process
D	0016787	molecular_function	hydrolase activity
D	0016788	molecular_function	hydrolase activity, acting on ester bonds
D	0017064	molecular_function	fatty acid amide hydrolase activity
D	0031090	cellular_component	organelle membrane
D	0042802	molecular_function	identical protein binding
D	0045907	biological_process	positive regulation of vasoconstriction
D	0047372	molecular_function	acylglycerol lipase activity
D	0052651	biological_process	monoacylglycerol catabolic process
D	0098793	cellular_component	presynapse
D	0098794	cellular_component	postsynapse
D	0098978	cellular_component	glutamatergic synapse
D	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue JXV A 601

Chain	Residue
A	PHE192
A	MET495
A	TRP531
A	SER193
A	TYR194
A	GLY239
A	SER241
A	LEU404
A	ILE407
A	PHE432
A	THR488

site_id	AC2
Number of Residues	8
Details	binding site for residue JXV B 601

Chain	Residue
B	ILE238
B	GLY239
B	SER241
B	LEU404
B	ILE407
B	PHE432
B	THR488
B	TRP531

site_id	AC3
Number of Residues	10
Details	binding site for residue JXV C 601

Chain	Residue
C	PHE192
C	SER193
C	ILE238
C	GLY239
C	PHE381
C	LEU404
C	ILE407
C	MET436
C	THR488
C	TRP531

site_id	AC4
Number of Residues	8
Details	binding site for residue JXV D 601

Chain	Residue
D	ILE238
D	GLY239
D	SER241
D	ILE407
D	PHE432
D	LEU433
D	THR488
D	TRP531

Functional Information from PROSITE/UniProt

site_id	PS00571
Number of Residues	32
Details	AMIDASES Amidases signature. GGSSGGeGAlIGsggsplGlGtDiGgSIRfPS

Chain	Residue	Details
A	GLY215-SER246

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	116
Details	INTRAMEM: INTRAMEM => ECO:0000305

Chain	Residue	Details
A	LEU404-LEU433
B	LEU404-LEU433
C	LEU404-LEU433
D	LEU404-LEU433

site_id	SWS_FT_FI2
Number of Residues	580
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	ASN434-SER579
B	ASN434-SER579
C	ASN434-SER579
D	ASN434-SER579

site_id	SWS_FT_FI3
Number of Residues	8
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
A	LYS142
A	SER217
B	LYS142
B	SER217
C	LYS142
C	SER217
D	LYS142
D	SER217

site_id	SWS_FT_FI4
Number of Residues	4
Details	ACT_SITE: Acyl-ester intermediate

Chain	Residue	Details
A	SER241
B	SER241
C	SER241
D	SER241

site_id	SWS_FT_FI5
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
A	MET191
D	MET191
D	SER217
D	ILE238
A	SER217
A	ILE238
B	MET191
B	SER217
B	ILE238
C	MET191
C	SER217
C	ILE238

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:O00519

Chain	Residue	Details
A	SER241
B	SER241
C	SER241
D	SER241

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
A	LYS142	proton acceptor, proton donor
A	SER217	proton acceptor, proton donor, proton relay
A	SER218	electrostatic stabiliser
A	ILE238	electrostatic stabiliser
A	GLY239	electrostatic stabiliser
A	GLY240	electrostatic stabiliser
A	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

site_id	MCSA2
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
B	LYS142	proton acceptor, proton donor
B	SER217	proton acceptor, proton donor, proton relay
B	SER218	electrostatic stabiliser
B	ILE238	electrostatic stabiliser
B	GLY239	electrostatic stabiliser
B	GLY240	electrostatic stabiliser
B	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

site_id	MCSA3
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
C	LYS142	proton acceptor, proton donor
C	SER217	proton acceptor, proton donor, proton relay
C	SER218	electrostatic stabiliser
C	ILE238	electrostatic stabiliser
C	GLY239	electrostatic stabiliser
C	GLY240	electrostatic stabiliser
C	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

site_id	MCSA4
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
D	LYS142	proton acceptor, proton donor
D	SER217	proton acceptor, proton donor, proton relay
D	SER218	electrostatic stabiliser
D	ILE238	electrostatic stabiliser
D	GLY239	electrostatic stabiliser
D	GLY240	electrostatic stabiliser
D	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)