Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6MRG

FAAH bound to non covalent inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0004040	molecular_function	amidase activity
A	0005515	molecular_function	protein binding
A	0005543	molecular_function	phospholipid binding
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0008289	molecular_function	lipid binding
A	0009062	biological_process	fatty acid catabolic process
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016788	molecular_function	hydrolase activity, acting on ester bonds
A	0017064	molecular_function	fatty acid amide hydrolase activity
A	0031090	cellular_component	organelle membrane
A	0035902	biological_process	response to immobilization stress
A	0042802	molecular_function	identical protein binding
A	0045471	biological_process	response to ethanol
A	0045907	biological_process	positive regulation of vasoconstriction
A	0047372	molecular_function	monoacylglycerol lipase activity
A	0052651	biological_process	monoacylglycerol catabolic process
A	0098793	cellular_component	presynapse
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse
A	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
B	0000139	cellular_component	Golgi membrane
B	0004040	molecular_function	amidase activity
B	0005515	molecular_function	protein binding
B	0005543	molecular_function	phospholipid binding
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0008289	molecular_function	lipid binding
B	0009062	biological_process	fatty acid catabolic process
B	0016042	biological_process	lipid catabolic process
B	0016787	molecular_function	hydrolase activity
B	0016788	molecular_function	hydrolase activity, acting on ester bonds
B	0017064	molecular_function	fatty acid amide hydrolase activity
B	0031090	cellular_component	organelle membrane
B	0035902	biological_process	response to immobilization stress
B	0042802	molecular_function	identical protein binding
B	0045471	biological_process	response to ethanol
B	0045907	biological_process	positive regulation of vasoconstriction
B	0047372	molecular_function	monoacylglycerol lipase activity
B	0052651	biological_process	monoacylglycerol catabolic process
B	0098793	cellular_component	presynapse
B	0098794	cellular_component	postsynapse
B	0098978	cellular_component	glutamatergic synapse
B	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
C	0000139	cellular_component	Golgi membrane
C	0004040	molecular_function	amidase activity
C	0005515	molecular_function	protein binding
C	0005543	molecular_function	phospholipid binding
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0008289	molecular_function	lipid binding
C	0009062	biological_process	fatty acid catabolic process
C	0016042	biological_process	lipid catabolic process
C	0016787	molecular_function	hydrolase activity
C	0016788	molecular_function	hydrolase activity, acting on ester bonds
C	0017064	molecular_function	fatty acid amide hydrolase activity
C	0031090	cellular_component	organelle membrane
C	0035902	biological_process	response to immobilization stress
C	0042802	molecular_function	identical protein binding
C	0045471	biological_process	response to ethanol
C	0045907	biological_process	positive regulation of vasoconstriction
C	0047372	molecular_function	monoacylglycerol lipase activity
C	0052651	biological_process	monoacylglycerol catabolic process
C	0098793	cellular_component	presynapse
C	0098794	cellular_component	postsynapse
C	0098978	cellular_component	glutamatergic synapse
C	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
D	0000139	cellular_component	Golgi membrane
D	0004040	molecular_function	amidase activity
D	0005515	molecular_function	protein binding
D	0005543	molecular_function	phospholipid binding
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0008289	molecular_function	lipid binding
D	0009062	biological_process	fatty acid catabolic process
D	0016042	biological_process	lipid catabolic process
D	0016787	molecular_function	hydrolase activity
D	0016788	molecular_function	hydrolase activity, acting on ester bonds
D	0017064	molecular_function	fatty acid amide hydrolase activity
D	0031090	cellular_component	organelle membrane
D	0035902	biological_process	response to immobilization stress
D	0042802	molecular_function	identical protein binding
D	0045471	biological_process	response to ethanol
D	0045907	biological_process	positive regulation of vasoconstriction
D	0047372	molecular_function	monoacylglycerol lipase activity
D	0052651	biological_process	monoacylglycerol catabolic process
D	0098793	cellular_component	presynapse
D	0098794	cellular_component	postsynapse
D	0098978	cellular_component	glutamatergic synapse
D	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue JXV A 601

Chain	Residue
A	PHE192
A	MET495
A	TRP531
A	SER193
A	TYR194
A	GLY239
A	SER241
A	LEU404
A	ILE407
A	PHE432
A	THR488

site_id	AC2
Number of Residues	8
Details	binding site for residue JXV B 601

Chain	Residue
B	ILE238
B	GLY239
B	SER241
B	LEU404
B	ILE407
B	PHE432
B	THR488
B	TRP531

site_id	AC3
Number of Residues	10
Details	binding site for residue JXV C 601

Chain	Residue
C	PHE192
C	SER193
C	ILE238
C	GLY239
C	PHE381
C	LEU404
C	ILE407
C	MET436
C	THR488
C	TRP531

site_id	AC4
Number of Residues	8
Details	binding site for residue JXV D 601

Chain	Residue
D	ILE238
D	GLY239
D	SER241
D	ILE407
D	PHE432
D	LEU433
D	THR488
D	TRP531

Functional Information from PROSITE/UniProt

site_id	PS00571
Number of Residues	32
Details	AMIDASES Amidases signature. GGSSGGeGAlIGsggsplGlGtDiGgSIRfPS

Chain	Residue	Details
A	GLY215-SER246

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	116
Details	Intramembrane: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Acyl-ester intermediate"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	20
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O00519","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
A	LYS142	proton acceptor, proton donor
A	SER217	proton acceptor, proton donor, proton relay
A	SER218	electrostatic stabiliser
A	ILE238	electrostatic stabiliser
A	GLY239	electrostatic stabiliser
A	GLY240	electrostatic stabiliser
A	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

site_id	MCSA2
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
B	LYS142	proton acceptor, proton donor
B	SER217	proton acceptor, proton donor, proton relay
B	SER218	electrostatic stabiliser
B	ILE238	electrostatic stabiliser
B	GLY239	electrostatic stabiliser
B	GLY240	electrostatic stabiliser
B	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

site_id	MCSA3
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
C	LYS142	proton acceptor, proton donor
C	SER217	proton acceptor, proton donor, proton relay
C	SER218	electrostatic stabiliser
C	ILE238	electrostatic stabiliser
C	GLY239	electrostatic stabiliser
C	GLY240	electrostatic stabiliser
C	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

site_id	MCSA4
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
D	LYS142	proton acceptor, proton donor
D	SER217	proton acceptor, proton donor, proton relay
D	SER218	electrostatic stabiliser
D	ILE238	electrostatic stabiliser
D	GLY239	electrostatic stabiliser
D	GLY240	electrostatic stabiliser
D	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)