6MN8

Crystal Structure of Prolyl-tRNA Synthetase from Onchocerca volvulus with bound Halofuginone and nucleotide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004827	molecular_function	proline-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006433	biological_process	prolyl-tRNA aminoacylation
A	0017101	cellular_component	aminoacyl-tRNA synthetase multienzyme complex
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MG A 601

Chain	Residue
A	VAL172
A	SER293
A	HOH737
A	HOH747
A	HOH782
A	HOH839

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site_id	AC2
Number of Residues	7
Details	binding site for residue MG A 602

Chain	Residue
A	HOH725
A	HOH731
A	HOH750
A	HOH768
A	ANP604
A	2PN606
A	HOH703

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site_id	AC3
Number of Residues	17
Details	binding site for residue HFG A 603

Chain	Residue
A	PHE135
A	GLU138
A	VAL139
A	PRO158
A	THR159
A	GLU161
A	ARG190
A	TRP207
A	THR278
A	HIS280
A	SER309
A	TRP310
A	GLY311
A	ANP604
A	AMP605
A	HOH768
A	HOH819

---

site_id	AC4
Number of Residues	31
Details	binding site for residue ANP A 604

Chain	Residue
A	ARG190
A	GLU192
A	PHE199
A	LEU200
A	ARG201
A	THR202
A	PHE205
A	TRP207
A	GLN275
A	GLY276
A	ALA277
A	THR278
A	GLY311
A	SER313
A	ARG315
A	MG602
A	HFG603
A	AMP605
A	2PN606
A	HOH701
A	HOH702
A	HOH703
A	HOH719
A	HOH725
A	HOH726
A	HOH727
A	HOH731
A	HOH750
A	HOH768
A	HOH795
A	HOH826

---

site_id	AC5
Number of Residues	21
Details	binding site for residue AMP A 605

Chain	Residue
A	ARG190
A	GLU192
A	PHE199
A	LEU200
A	ARG201
A	THR202
A	PHE205
A	TRP207
A	GLN275
A	GLY276
A	ALA277
A	THR278
A	SER313
A	ARG315
A	HFG603
A	ANP604
A	2PN606
A	HOH702
A	HOH703
A	HOH725
A	HOH726

---

site_id	AC6
Number of Residues	14
Details	binding site for residue 2PN A 606

Chain	Residue
A	ARG201
A	GLN275
A	ARG315
A	MG602
A	ANP604
A	AMP605
A	HOH701
A	HOH702
A	HOH703
A	HOH719
A	HOH725
A	HOH731
A	HOH750
A	HOH795

---

site_id	AC7
Number of Residues	2
Details	binding site for residue GLY A 607

Chain	Residue
A	GLU379
A	LEU380

---

site_id	AC8
Number of Residues	3
Details	binding site for residue GLY A 608

Chain	Residue
A	PRO89
A	HOH740
A	ARG88

---

site_id	AC9
Number of Residues	1
Details	binding site for residue GLY A 609

Chain	Residue
A	CYS328

---

site_id	AD1
Number of Residues	4
Details	binding site for residue SER A 610

Chain	Residue
A	GLN122
A	TRP141
A	ARG144
A	ALA153

---

site_id	AD2
Number of Residues	4
Details	binding site for residue SER A 611

Chain	Residue
A	TRP101
A	LEU238
A	ASP440
A	HOH738

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