Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6MN5

Crystal structure of aminoglycoside acetyltransferase AAC(3)-IVa, H154A mutant, in complex with gentamicin C1A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008080	molecular_function	N-acetyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding
B	0008080	molecular_function	N-acetyltransferase activity
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0046677	biological_process	response to antibiotic
B	0046872	molecular_function	metal ion binding
C	0008080	molecular_function	N-acetyltransferase activity
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0046677	biological_process	response to antibiotic
C	0046872	molecular_function	metal ion binding
D	0008080	molecular_function	N-acetyltransferase activity
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0046677	biological_process	response to antibiotic
D	0046872	molecular_function	metal ion binding
E	0008080	molecular_function	N-acetyltransferase activity
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0046677	biological_process	response to antibiotic
E	0046872	molecular_function	metal ion binding
F	0008080	molecular_function	N-acetyltransferase activity
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0046677	biological_process	response to antibiotic
F	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue LLL A 301

Chain	Residue
A	ASP67
A	GLU185
A	ASP187
A	CYS189
A	CYS190
A	GLU249
A	EDO311

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 302

Chain	Residue
A	CYS247
A	CYS250
A	CYS189
A	HIS241

site_id	AC3
Number of Residues	8
Details	binding site for residue EPE A 303

Chain	Residue
A	GLU4
A	PHE31
A	ARG35
A	PRO36
A	LEU37
A	GLU38
A	GLY40
B	ALA74

site_id	AC4
Number of Residues	7
Details	binding site for residue EPE A 304

Chain	Residue
A	SER30
A	PHE31
A	ARG32
A	ASP81
A	GLY83
A	VAL84
A	HOH418

site_id	AC5
Number of Residues	4
Details	binding site for residue GOL A 305

Chain	Residue
A	PRO80
A	ASP87
A	HOH462
B	THR75

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 306

Chain	Residue
A	ARG91
A	HOH402
A	HOH416
B	ASP39
B	LEU42

site_id	AC7
Number of Residues	2
Details	binding site for residue EDO A 307

Chain	Residue
C	SER204
C	LYS207

site_id	AC8
Number of Residues	6
Details	binding site for residue EDO A 308

Chain	Residue
A	ASP39
A	GLY40
A	PRO41
A	LEU42
A	HOH408
B	ARG91

site_id	AC9
Number of Residues	1
Details	binding site for residue EDO A 309

Chain	Residue
A	ASP39

site_id	AD1
Number of Residues	2
Details	binding site for residue EDO A 310

Chain	Residue
A	ARG97
A	HOH426

site_id	AD2
Number of Residues	2
Details	binding site for residue EDO A 311

Chain	Residue
A	HIS124
A	LLL301

site_id	AD3
Number of Residues	1
Details	binding site for residue EDO A 312

Chain	Residue
A	SER116

site_id	AD4
Number of Residues	2
Details	binding site for residue EDO A 313

Chain	Residue
A	ARG220
A	ASP223

site_id	AD5
Number of Residues	5
Details	binding site for residue EDO A 314

Chain	Residue
A	ARG192
A	ASP235
A	LEU237
A	LEU240
A	ARG254

site_id	AD6
Number of Residues	4
Details	binding site for residue EDO A 315

Chain	Residue
A	LEU119
A	PRO120
A	LEU121
A	SER125

site_id	AD7
Number of Residues	6
Details	binding site for residue EDO A 316

Chain	Residue
A	GLN139
A	LEU205
A	LYS207
A	LEU218
A	ARG220
A	HOH411

site_id	AD8
Number of Residues	9
Details	binding site for residue LLL B 301

Chain	Residue
B	ASP67
B	GLU185
B	ASP187
B	HIS188
B	CYS189
B	CYS190
B	GLU249
B	EDO312
B	HOH401

site_id	AD9
Number of Residues	4
Details	binding site for residue ZN B 302

Chain	Residue
B	CYS189
B	HIS241
B	CYS247
B	CYS250

site_id	AE1
Number of Residues	9
Details	binding site for residue EPE B 303

Chain	Residue
A	ALA74
B	GLU4
B	PHE31
B	ARG35
B	PRO36
B	LEU37
B	GLU38
B	GLY40
B	HOH463

site_id	AE2
Number of Residues	6
Details	binding site for residue EPE B 304

Chain	Residue
B	SER30
B	PHE31
B	ARG32
B	ASP81
B	GLY83
B	VAL84

site_id	AE3
Number of Residues	4
Details	binding site for residue GOL B 305

Chain	Residue
B	PRO73
B	LYS96
B	ARG97
B	EDO306

site_id	AE4
Number of Residues	2
Details	binding site for residue EDO B 306

Chain	Residue
B	GOL305
B	GLU112

site_id	AE5
Number of Residues	5
Details	binding site for residue EDO B 307

Chain	Residue
B	ARG192
B	ASP235
B	LEU237
B	LEU240
B	ARG254

site_id	AE6
Number of Residues	3
Details	binding site for residue EDO B 308

Chain	Residue
A	PRO93
B	ASP39
B	GLU46

site_id	AE7
Number of Residues	2
Details	binding site for residue EDO B 309

Chain	Residue
B	LYS7
B	GLU46

site_id	AE8
Number of Residues	2
Details	binding site for residue EDO B 310

Chain	Residue
B	ARG49
B	PRO54

site_id	AE9
Number of Residues	5
Details	binding site for residue EDO B 311

Chain	Residue
A	GLN113
B	LEU52
B	GLY53
B	PRO54
B	GLY55

site_id	AF1
Number of Residues	2
Details	binding site for residue EDO B 312

Chain	Residue
B	HIS124
B	LLL301

site_id	AF2
Number of Residues	2
Details	binding site for residue EDO B 313

Chain	Residue
B	THR20
B	PRO21

site_id	AF3
Number of Residues	5
Details	binding site for residue PE3 B 314

Chain	Residue
B	ASP197
B	LYS201
B	GLU208
B	ARG217
B	HOH442

site_id	AF4
Number of Residues	7
Details	binding site for residue LLL C 301

Chain	Residue
C	ASP67
C	GLU185
C	ASP187
C	CYS189
C	CYS190
C	GLU249
C	EDO308

site_id	AF5
Number of Residues	4
Details	binding site for residue ZN C 302

Chain	Residue
C	CYS189
C	HIS241
C	CYS247
C	CYS250

site_id	AF6
Number of Residues	6
Details	binding site for residue EPE C 303

Chain	Residue
C	SER30
C	PHE31
C	ARG32
C	ASP81
C	GLY83
C	VAL84

site_id	AF7
Number of Residues	8
Details	binding site for residue EPE C 304

Chain	Residue
C	GLU4
C	PHE31
C	ARG35
C	PRO36
C	LEU37
C	GLU38
C	GLY40
F	ALA74

site_id	AF8
Number of Residues	5
Details	binding site for residue GOL C 305

Chain	Residue
C	ASP39
C	GLY40
C	PRO41
C	LEU42
F	ARG91

site_id	AF9
Number of Residues	2
Details	binding site for residue EDO C 306

Chain	Residue
C	ARG217
C	HOH422

site_id	AG1
Number of Residues	3
Details	binding site for residue EDO C 307

Chain	Residue
B	GLU208
C	GLU9
C	HOH404

site_id	AG2
Number of Residues	4
Details	binding site for residue EDO C 308

Chain	Residue
C	TRP63
C	PHE102
C	HIS124
C	LLL301

site_id	AG3
Number of Residues	3
Details	binding site for residue EDO C 309

Chain	Residue
C	LYS7
C	ALA50
C	HOH441

site_id	AG4
Number of Residues	2
Details	binding site for residue EDO C 311

Chain	Residue
C	ASN94
F	GLU46

site_id	AG5
Number of Residues	6
Details	binding site for residue EDO C 312

Chain	Residue
C	ASP235
C	LEU237
C	LEU240
C	HIS241
C	PRO242
C	ARG254

site_id	AG6
Number of Residues	1
Details	binding site for residue EDO C 313

Chain	Residue
C	TRP63

site_id	AG7
Number of Residues	6
Details	binding site for residue EDO C 314

Chain	Residue
C	GLN139
C	LEU205
C	LYS207
C	LEU218
C	ARG220
C	HOH435

site_id	AG8
Number of Residues	2
Details	binding site for residue PE3 C 315

Chain	Residue
C	ARG132
C	HIS134

site_id	AG9
Number of Residues	8
Details	binding site for residue LLL D 301

Chain	Residue
D	ASP67
D	GLU185
D	ASP187
D	CYS189
D	CYS190
D	GLU249
D	EDO311
D	HOH430

site_id	AH1
Number of Residues	4
Details	binding site for residue ZN D 302

Chain	Residue
D	CYS189
D	HIS241
D	CYS247
D	CYS250

site_id	AH2
Number of Residues	8
Details	binding site for residue EPE D 303

Chain	Residue
D	GLU4
D	PHE31
D	ARG35
D	PRO36
D	LEU37
D	GLU38
D	GLY40
E	ALA74

site_id	AH3
Number of Residues	6
Details	binding site for residue EPE D 304

Chain	Residue
D	SER30
D	PHE31
D	ARG32
D	ASP81
D	GLY83
D	VAL84

site_id	AH4
Number of Residues	3
Details	binding site for residue GOL D 305

Chain	Residue
D	PRO73
D	LYS96
D	ARG97

site_id	AH5
Number of Residues	3
Details	binding site for residue EDO D 307

Chain	Residue
D	PRO80
D	GLY83
D	ASP87

site_id	AH6
Number of Residues	4
Details	binding site for residue EDO D 308

Chain	Residue
C	PRO54
D	ASN16
D	GLY18
D	LYS207

site_id	AH7
Number of Residues	6
Details	binding site for residue EDO D 309

Chain	Residue
D	ASP39
D	GLY40
D	PRO41
D	LEU42
D	HOH425
E	ARG91

site_id	AH8
Number of Residues	3
Details	binding site for residue EDO D 310

Chain	Residue
D	GLU46
D	HOH415
E	PRO93

site_id	AH9
Number of Residues	4
Details	binding site for residue EDO D 311

Chain	Residue
D	TRP63
D	PHE102
D	HIS124
D	LLL301

site_id	AI1
Number of Residues	2
Details	binding site for residue EDO D 312

Chain	Residue
C	ALA51
D	ASN16

site_id	AI2
Number of Residues	3
Details	binding site for residue EDO D 313

Chain	Residue
D	TRP63
D	GLY65
D	THR79

site_id	AI3
Number of Residues	1
Details	binding site for residue EDO D 314

Chain	Residue
D	GLU202

site_id	AI4
Number of Residues	5
Details	binding site for residue PE3 D 315

Chain	Residue
D	ASP197
D	ARG198
D	LYS201
D	GLU208
D	ARG217

site_id	AI5
Number of Residues	10
Details	binding site for residue LLL E 301

Chain	Residue
E	GLY65
E	ASP67
E	ARG168
E	TYR183
E	GLU185
E	HIS188
E	CYS189
E	CYS190
E	GLU249
E	EDO308

site_id	AI6
Number of Residues	4
Details	binding site for residue ZN E 302

Chain	Residue
E	CYS189
E	HIS241
E	CYS247
E	CYS250

site_id	AI7
Number of Residues	8
Details	binding site for residue EPE E 303

Chain	Residue
D	ALA74
E	GLU4
E	PHE31
E	ARG35
E	PRO36
E	LEU37
E	GLU38
E	GLY40

site_id	AI8
Number of Residues	6
Details	binding site for residue EPE E 304

Chain	Residue
E	PHE31
E	ARG32
E	PRO80
E	ASP81
E	GLY83
E	VAL84

site_id	AI9
Number of Residues	1
Details	binding site for residue EDO E 305

Chain	Residue
E	ARG97

site_id	AJ1
Number of Residues	2
Details	binding site for residue EDO E 306

Chain	Residue
E	GLN-1
F	GLN2

site_id	AJ2
Number of Residues	3
Details	binding site for residue EDO E 307

Chain	Residue
E	LYS7
E	GLU38
E	ASP39

site_id	AJ3
Number of Residues	3
Details	binding site for residue EDO E 308

Chain	Residue
E	PRO123
E	HIS124
E	LLL301

site_id	AJ4
Number of Residues	8
Details	binding site for residue LLL F 301

Chain	Residue
F	GLY65
F	ASP67
F	TYR183
F	GLU185
F	ASP187
F	CYS189
F	CYS190
F	HOH405

site_id	AJ5
Number of Residues	4
Details	binding site for residue ZN F 302

Chain	Residue
F	CYS189
F	HIS241
F	CYS247
F	CYS250

site_id	AJ6
Number of Residues	9
Details	binding site for residue EPE F 303

Chain	Residue
C	ALA74
F	GLU4
F	PHE31
F	ARG35
F	PRO36
F	LEU37
F	GLU38
F	GLY40
F	HOH409

site_id	AJ7
Number of Residues	6
Details	binding site for residue EPE F 304

Chain	Residue
F	SER30
F	PHE31
F	ARG32
F	ASP81
F	GLY83
F	VAL84

site_id	AJ8
Number of Residues	2
Details	binding site for residue EDO F 305

Chain	Residue
F	ASN16
F	GLY18

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)