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6MM7

Catalytic subunit of cAMP-dependent protein kinase A in complex with RyR2 K2879A, S2813D phosphomimetic (2699-2904) crystal form 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000287molecular_functionmagnesium ion binding
A0001669cellular_componentacrosomal vesicle
A0001707biological_processmesoderm formation
A0001843biological_processneural tube closure
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004679molecular_functionAMP-activated protein kinase activity
A0004691molecular_functioncAMP-dependent protein kinase activity
A0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005930cellular_componentaxoneme
A0005952cellular_componentcAMP-dependent protein kinase complex
A0006397biological_processmRNA processing
A0006468biological_processprotein phosphorylation
A0006611biological_processprotein export from nucleus
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0008284biological_processpositive regulation of cell population proliferation
A0010737biological_processprotein kinase A signaling
A0016607cellular_componentnuclear speck
A0018105biological_processpeptidyl-serine phosphorylation
A0019901molecular_functionprotein kinase binding
A0019904molecular_functionprotein domain specific binding
A0030145molecular_functionmanganese ion binding
A0031267molecular_functionsmall GTPase binding
A0031410cellular_componentcytoplasmic vesicle
A0031514cellular_componentmotile cilium
A0031594cellular_componentneuromuscular junction
A0031625molecular_functionubiquitin protein ligase binding
A0032024biological_processpositive regulation of insulin secretion
A0032991cellular_componentprotein-containing complex
A0034237molecular_functionprotein kinase A regulatory subunit binding
A0034605biological_processcellular response to heat
A0036126cellular_componentsperm flagellum
A0043197cellular_componentdendritic spine
A0043457biological_processregulation of cellular respiration
A0044853cellular_componentplasma membrane raft
A0044877molecular_functionprotein-containing complex binding
A0045667biological_processregulation of osteoblast differentiation
A0045722biological_processpositive regulation of gluconeogenesis
A0045879biological_processnegative regulation of smoothened signaling pathway
A0046827biological_processpositive regulation of protein export from nucleus
A0048240biological_processsperm capacitation
A0048471cellular_componentperinuclear region of cytoplasm
A0048792biological_processspontaneous exocytosis of neurotransmitter
A0050804biological_processmodulation of chemical synaptic transmission
A0051447biological_processnegative regulation of meiotic cell cycle
A0051726biological_processregulation of cell cycle
A0051966biological_processregulation of synaptic transmission, glutamatergic
A0061136biological_processregulation of proteasomal protein catabolic process
A0070417biological_processcellular response to cold
A0070613biological_processregulation of protein processing
A0071333biological_processcellular response to glucose stimulus
A0071374biological_processcellular response to parathyroid hormone stimulus
A0071377biological_processcellular response to glucagon stimulus
A0097546cellular_componentciliary base
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099170biological_processpostsynaptic modulation of chemical synaptic transmission
A0106310molecular_functionprotein serine kinase activity
A1904262biological_processnegative regulation of TORC1 signaling
A1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
A1990044biological_processprotein localization to lipid droplet
A2000810biological_processregulation of bicellular tight junction assembly
C0006816biological_processcalcium ion transport
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000287molecular_functionmagnesium ion binding
D0001669cellular_componentacrosomal vesicle
D0001707biological_processmesoderm formation
D0001843biological_processneural tube closure
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0004679molecular_functionAMP-activated protein kinase activity
D0004691molecular_functioncAMP-dependent protein kinase activity
D0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005930cellular_componentaxoneme
D0005952cellular_componentcAMP-dependent protein kinase complex
D0006397biological_processmRNA processing
D0006468biological_processprotein phosphorylation
D0006611biological_processprotein export from nucleus
D0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
D0008284biological_processpositive regulation of cell population proliferation
D0010737biological_processprotein kinase A signaling
D0016607cellular_componentnuclear speck
D0018105biological_processpeptidyl-serine phosphorylation
D0019901molecular_functionprotein kinase binding
D0019904molecular_functionprotein domain specific binding
D0030145molecular_functionmanganese ion binding
D0031267molecular_functionsmall GTPase binding
D0031410cellular_componentcytoplasmic vesicle
D0031514cellular_componentmotile cilium
D0031594cellular_componentneuromuscular junction
D0031625molecular_functionubiquitin protein ligase binding
D0032024biological_processpositive regulation of insulin secretion
D0032991cellular_componentprotein-containing complex
D0034237molecular_functionprotein kinase A regulatory subunit binding
D0034605biological_processcellular response to heat
D0036126cellular_componentsperm flagellum
D0043197cellular_componentdendritic spine
D0043457biological_processregulation of cellular respiration
D0044853cellular_componentplasma membrane raft
D0044877molecular_functionprotein-containing complex binding
D0045667biological_processregulation of osteoblast differentiation
D0045722biological_processpositive regulation of gluconeogenesis
D0045879biological_processnegative regulation of smoothened signaling pathway
D0046827biological_processpositive regulation of protein export from nucleus
D0048240biological_processsperm capacitation
D0048471cellular_componentperinuclear region of cytoplasm
D0048792biological_processspontaneous exocytosis of neurotransmitter
D0050804biological_processmodulation of chemical synaptic transmission
D0051447biological_processnegative regulation of meiotic cell cycle
D0051726biological_processregulation of cell cycle
D0051966biological_processregulation of synaptic transmission, glutamatergic
D0061136biological_processregulation of proteasomal protein catabolic process
D0070417biological_processcellular response to cold
D0070613biological_processregulation of protein processing
D0071333biological_processcellular response to glucose stimulus
D0071374biological_processcellular response to parathyroid hormone stimulus
D0071377biological_processcellular response to glucagon stimulus
D0097546cellular_componentciliary base
D0098793cellular_componentpresynapse
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0099170biological_processpostsynaptic modulation of chemical synaptic transmission
D0106310molecular_functionprotein serine kinase activity
D1904262biological_processnegative regulation of TORC1 signaling
D1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
D1990044biological_processprotein localization to lipid droplet
D2000810biological_processregulation of bicellular tight junction assembly
E0006816biological_processcalcium ion transport
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue FMT A 401
ChainResidue
ALYS83
AGLN84
AILE85
AGLU86
AHOH568
AHOH621

site_idAC2
Number of Residues2
Detailsbinding site for residue FMT A 402
ChainResidue
AHIS142
EHOH3161

site_idAC3
Number of Residues6
Detailsbinding site for residue ACY A 403
ChainResidue
AALA148
ATHR300
AILE305
AHOH577
AHOH647
AARG144

site_idAC4
Number of Residues2
Detailsbinding site for residue FMT A 404
ChainResidue
AHIS131
ATYR146

site_idAC5
Number of Residues3
Detailsbinding site for residue FMT A 405
ChainResidue
AGLY55
AARG56
AILE73

site_idAC6
Number of Residues14
Detailsbinding site for residue ANP A 406
ChainResidue
ALEU49
ATHR51
AGLY52
ASER53
AVAL57
AALA70
ALYS72
AGLU121
ATYR122
AVAL123
AHOH506
AHOH519
AHOH549
AHOH716

site_idAC7
Number of Residues5
Detailsbinding site for residue EDO A 407
ChainResidue
APHE138
ASER139
AHIS142
EALA2783
ETRP2784

site_idAC8
Number of Residues5
Detailsbinding site for residue EDO C 3001
ChainResidue
CPRO2713
CLYS2715
CLEU2782
CARG2787
CILE2788

site_idAC9
Number of Residues6
Detailsbinding site for residue FMT D 401
ChainResidue
DHIS158
DLYS217
DTRP221
DGLY282
DHOH509
DHOH652

site_idAD1
Number of Residues5
Detailsbinding site for residue FMT D 402
ChainResidue
DLYS83
DGLN84
DILE85
DGLU86
DHOH659

site_idAD2
Number of Residues5
Detailsbinding site for residue FMT D 403
ChainResidue
DHIS131
DILE135
DTYR146
DPHE314
DEDO407

site_idAD3
Number of Residues5
Detailsbinding site for residue FMT D 404
ChainResidue
DTHR37
DALA38
DGLN42
DHIS62
DHOH705

site_idAD4
Number of Residues13
Detailsbinding site for residue ANP D 405
ChainResidue
DLEU49
DTHR51
DGLY52
DSER53
DVAL57
DALA70
DLYS72
DGLU121
DVAL123
DASP184
DHOH645
DHOH718
DHOH721

site_idAD5
Number of Residues4
Detailsbinding site for residue CL D 406
ChainResidue
CTRP2786
CARG2904
CHOH3203
DGLU140

site_idAD6
Number of Residues7
Detailsbinding site for residue EDO D 407
ChainResidue
CVAL2705
DILE135
DARG137
DPHE138
DSER139
DHIS142
DFMT403

site_idAD7
Number of Residues5
Detailsbinding site for residue EDO D 408
ChainResidue
DLYS72
DGLU91
DMET120
DTHR183
DHOH547

site_idAD8
Number of Residues7
Detailsbinding site for residue EDO D 409
ChainResidue
DHOH557
DARG144
DTHR299
DTHR300
DILE305
DVAL310
DHOH504

site_idAD9
Number of Residues5
Detailsbinding site for residue EDO D 410
ChainResidue
DTYR69
DGLU107
DHOH505
DHOH625
EHOH3192

site_idAE1
Number of Residues4
Detailsbinding site for residue CL E 3001
ChainResidue
AGLU140
ETRP2786
EMET2842
EARG2904

site_idAE2
Number of Residues4
Detailsbinding site for residue EDO E 3002
ChainResidue
EARG2805
EILE2806
EHOH3112
EHOH3177

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhkesgnh..........YAMK
ChainResidueDetails
ALEU49-LYS72

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI
ChainResidueDetails
ALEU162-ILE174

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079
ChainResidueDetails
CSER2796
CSER2810
ESER2796
ESER2810

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine; by CaMK2D and PKA => ECO:0000269|PubMed:20431056, ECO:0000269|PubMed:21098440, ECO:0007744|PubMed:21183079
ChainResidueDetails
CSER2807
ESER2807
AGLU121
ALYS168
DLEU49
DLYS72
DGLU121
DLYS168

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by CaMK2D => ECO:0000269|PubMed:21098440, ECO:0007744|PubMed:21183079
ChainResidueDetails
CASP2813
EASP2813
DTHR48
DTHR195

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:22323819, ECO:0000305|PubMed:8395513
ChainResidueDetails
ASER139
DSER139

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:22323819, ECO:0000269|PubMed:8395513, ECO:0000269|PubMed:9707564
ChainResidueDetails
ATPO197
DTPO197

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:21866565
ChainResidueDetails
ATYR330
DTYR330

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000305|PubMed:8395513
ChainResidueDetails
ASEP338
DSEP338

219140

PDB entries from 2024-05-01

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