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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6MM7

Catalytic subunit of cAMP-dependent protein kinase A in complex with RyR2 K2879A, S2813D phosphomimetic (2699-2904) crystal form 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0001669cellular_componentacrosomal vesicle
A0001707biological_processmesoderm formation
A0001843biological_processneural tube closure
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004691molecular_functioncAMP-dependent protein kinase activity
A0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005811cellular_componentlipid droplet
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005930cellular_componentaxoneme
A0005952cellular_componentcAMP-dependent protein kinase complex
A0006338biological_processchromatin remodeling
A0006397biological_processmRNA processing
A0006468biological_processprotein phosphorylation
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0008284biological_processpositive regulation of cell population proliferation
A0010898biological_processpositive regulation of triglyceride catabolic process
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016607cellular_componentnuclear speck
A0016740molecular_functiontransferase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0018107biological_processpeptidyl-threonine phosphorylation
A0019870molecular_functionpotassium channel inhibitor activity
A0019901molecular_functionprotein kinase binding
A0019904molecular_functionprotein domain specific binding
A0030007biological_processintracellular potassium ion homeostasis
A0030145molecular_functionmanganese ion binding
A0031267molecular_functionsmall GTPase binding
A0031410cellular_componentcytoplasmic vesicle
A0031514cellular_componentmotile cilium
A0031588cellular_componentnucleotide-activated protein kinase complex
A0031594cellular_componentneuromuscular junction
A0031625molecular_functionubiquitin protein ligase binding
A0031669biological_processcellular response to nutrient levels
A0032991cellular_componentprotein-containing complex
A0034237molecular_functionprotein kinase A regulatory subunit binding
A0034605biological_processcellular response to heat
A0036126cellular_componentsperm flagellum
A0038110biological_processinterleukin-2-mediated signaling pathway
A0038202biological_processTORC1 signaling
A0043457biological_processregulation of cellular respiration
A0044853cellular_componentplasma membrane raft
A0044877molecular_functionprotein-containing complex binding
A0045542biological_processpositive regulation of cholesterol biosynthetic process
A0045667biological_processregulation of osteoblast differentiation
A0045722biological_processpositive regulation of gluconeogenesis
A0045820biological_processnegative regulation of glycolytic process
A0045879biological_processnegative regulation of smoothened signaling pathway
A0046777biological_processprotein autophosphorylation
A0046827biological_processpositive regulation of protein export from nucleus
A0048240biological_processsperm capacitation
A0048471cellular_componentperinuclear region of cytoplasm
A0048792biological_processspontaneous exocytosis of neurotransmitter
A0050766biological_processpositive regulation of phagocytosis
A0050804biological_processmodulation of chemical synaptic transmission
A0051447biological_processnegative regulation of meiotic cell cycle
A0051726biological_processregulation of cell cycle
A0051966biological_processregulation of synaptic transmission, glutamatergic
A0061136biological_processregulation of proteasomal protein catabolic process
A0070417biological_processcellular response to cold
A0070507biological_processregulation of microtubule cytoskeleton organization
A0070613biological_processregulation of protein processing
A0071333biological_processcellular response to glucose stimulus
A0071374biological_processcellular response to parathyroid hormone stimulus
A0071377biological_processcellular response to glucagon stimulus
A0097225cellular_componentsperm midpiece
A0097546cellular_componentciliary base
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099170biological_processpostsynaptic modulation of chemical synaptic transmission
A0106310molecular_functionprotein serine kinase activity
A0120186biological_processnegative regulation of protein localization to chromatin
A0140198molecular_functionhistone H1-4S35 kinase activity
A0141156biological_processcAMP/PKA signal transduction
A1904262biological_processnegative regulation of TORC1 signaling
A1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
A1990044biological_processprotein localization to lipid droplet
A2000810biological_processregulation of bicellular tight junction assembly
C0006816biological_processcalcium ion transport
D0000166molecular_functionnucleotide binding
D0000287molecular_functionmagnesium ion binding
D0001669cellular_componentacrosomal vesicle
D0001707biological_processmesoderm formation
D0001843biological_processneural tube closure
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0004691molecular_functioncAMP-dependent protein kinase activity
D0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005811cellular_componentlipid droplet
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005930cellular_componentaxoneme
D0005952cellular_componentcAMP-dependent protein kinase complex
D0006338biological_processchromatin remodeling
D0006397biological_processmRNA processing
D0006468biological_processprotein phosphorylation
D0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
D0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
D0008284biological_processpositive regulation of cell population proliferation
D0010898biological_processpositive regulation of triglyceride catabolic process
D0016020cellular_componentmembrane
D0016301molecular_functionkinase activity
D0016607cellular_componentnuclear speck
D0016740molecular_functiontransferase activity
D0018105biological_processpeptidyl-serine phosphorylation
D0018107biological_processpeptidyl-threonine phosphorylation
D0019870molecular_functionpotassium channel inhibitor activity
D0019901molecular_functionprotein kinase binding
D0019904molecular_functionprotein domain specific binding
D0030007biological_processintracellular potassium ion homeostasis
D0030145molecular_functionmanganese ion binding
D0031267molecular_functionsmall GTPase binding
D0031410cellular_componentcytoplasmic vesicle
D0031514cellular_componentmotile cilium
D0031588cellular_componentnucleotide-activated protein kinase complex
D0031594cellular_componentneuromuscular junction
D0031625molecular_functionubiquitin protein ligase binding
D0031669biological_processcellular response to nutrient levels
D0032991cellular_componentprotein-containing complex
D0034237molecular_functionprotein kinase A regulatory subunit binding
D0034605biological_processcellular response to heat
D0036126cellular_componentsperm flagellum
D0038110biological_processinterleukin-2-mediated signaling pathway
D0038202biological_processTORC1 signaling
D0043457biological_processregulation of cellular respiration
D0044853cellular_componentplasma membrane raft
D0044877molecular_functionprotein-containing complex binding
D0045542biological_processpositive regulation of cholesterol biosynthetic process
D0045667biological_processregulation of osteoblast differentiation
D0045722biological_processpositive regulation of gluconeogenesis
D0045820biological_processnegative regulation of glycolytic process
D0045879biological_processnegative regulation of smoothened signaling pathway
D0046777biological_processprotein autophosphorylation
D0046827biological_processpositive regulation of protein export from nucleus
D0048240biological_processsperm capacitation
D0048471cellular_componentperinuclear region of cytoplasm
D0048792biological_processspontaneous exocytosis of neurotransmitter
D0050766biological_processpositive regulation of phagocytosis
D0050804biological_processmodulation of chemical synaptic transmission
D0051447biological_processnegative regulation of meiotic cell cycle
D0051726biological_processregulation of cell cycle
D0051966biological_processregulation of synaptic transmission, glutamatergic
D0061136biological_processregulation of proteasomal protein catabolic process
D0070417biological_processcellular response to cold
D0070507biological_processregulation of microtubule cytoskeleton organization
D0070613biological_processregulation of protein processing
D0071333biological_processcellular response to glucose stimulus
D0071374biological_processcellular response to parathyroid hormone stimulus
D0071377biological_processcellular response to glucagon stimulus
D0097225cellular_componentsperm midpiece
D0097546cellular_componentciliary base
D0098793cellular_componentpresynapse
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0099170biological_processpostsynaptic modulation of chemical synaptic transmission
D0106310molecular_functionprotein serine kinase activity
D0120186biological_processnegative regulation of protein localization to chromatin
D0140198molecular_functionhistone H1-4S35 kinase activity
D0141156biological_processcAMP/PKA signal transduction
D1904262biological_processnegative regulation of TORC1 signaling
D1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
D1990044biological_processprotein localization to lipid droplet
D2000810biological_processregulation of bicellular tight junction assembly
E0006816biological_processcalcium ion transport
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue FMT A 401
ChainResidue
ALYS83
AGLN84
AILE85
AGLU86
AHOH568
AHOH621
site_idAC2
Number of Residues2
Detailsbinding site for residue FMT A 402
ChainResidue
AHIS142
EHOH3161
site_idAC3
Number of Residues6
Detailsbinding site for residue ACY A 403
ChainResidue
AALA148
ATHR300
AILE305
AHOH577
AHOH647
AARG144
site_idAC4
Number of Residues2
Detailsbinding site for residue FMT A 404
ChainResidue
AHIS131
ATYR146
site_idAC5
Number of Residues3
Detailsbinding site for residue FMT A 405
ChainResidue
AGLY55
AARG56
AILE73
site_idAC6
Number of Residues14
Detailsbinding site for residue ANP A 406
ChainResidue
ALEU49
ATHR51
AGLY52
ASER53
AVAL57
AALA70
ALYS72
AGLU121
ATYR122
AVAL123
AHOH506
AHOH519
AHOH549
AHOH716
site_idAC7
Number of Residues5
Detailsbinding site for residue EDO A 407
ChainResidue
APHE138
ASER139
AHIS142
EALA2783
ETRP2784
site_idAC8
Number of Residues5
Detailsbinding site for residue EDO C 3001
ChainResidue
CPRO2713
CLYS2715
CLEU2782
CARG2787
CILE2788
site_idAC9
Number of Residues6
Detailsbinding site for residue FMT D 401
ChainResidue
DHIS158
DLYS217
DTRP221
DGLY282
DHOH509
DHOH652
site_idAD1
Number of Residues5
Detailsbinding site for residue FMT D 402
ChainResidue
DLYS83
DGLN84
DILE85
DGLU86
DHOH659
site_idAD2
Number of Residues5
Detailsbinding site for residue FMT D 403
ChainResidue
DHIS131
DILE135
DTYR146
DPHE314
DEDO407
site_idAD3
Number of Residues5
Detailsbinding site for residue FMT D 404
ChainResidue
DTHR37
DALA38
DGLN42
DHIS62
DHOH705
site_idAD4
Number of Residues13
Detailsbinding site for residue ANP D 405
ChainResidue
DLEU49
DTHR51
DGLY52
DSER53
DVAL57
DALA70
DLYS72
DGLU121
DVAL123
DASP184
DHOH645
DHOH718
DHOH721
site_idAD5
Number of Residues4
Detailsbinding site for residue CL D 406
ChainResidue
CTRP2786
CARG2904
CHOH3203
DGLU140
site_idAD6
Number of Residues7
Detailsbinding site for residue EDO D 407
ChainResidue
CVAL2705
DILE135
DARG137
DPHE138
DSER139
DHIS142
DFMT403
site_idAD7
Number of Residues5
Detailsbinding site for residue EDO D 408
ChainResidue
DLYS72
DGLU91
DMET120
DTHR183
DHOH547
site_idAD8
Number of Residues7
Detailsbinding site for residue EDO D 409
ChainResidue
DHOH557
DARG144
DTHR299
DTHR300
DILE305
DVAL310
DHOH504
site_idAD9
Number of Residues5
Detailsbinding site for residue EDO D 410
ChainResidue
DTYR69
DGLU107
DHOH505
DHOH625
EHOH3192
site_idAE1
Number of Residues4
Detailsbinding site for residue CL E 3001
ChainResidue
AGLU140
ETRP2786
EMET2842
EARG2904
site_idAE2
Number of Residues4
Detailsbinding site for residue EDO E 3002
ChainResidue
EARG2805
EILE2806
EHOH3112
EHOH3177
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhkesgnh..........YAMK
ChainResidueDetails
ALEU49-LYS72
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI
ChainResidueDetails
ALEU162-ILE174
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"description":"Proton acceptor"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues36
DetailsBinding site: {}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P17612","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22323819","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8395513","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by PDPK1","evidences":[{"source":"PubMed","id":"22323819","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8395513","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9707564","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"21866565","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"8395513","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by CaMK2D and PKA","evidences":[{"source":"PubMed","id":"20431056","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21098440","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by CaMK2D","evidences":[{"source":"PubMed","id":"21098440","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

250059

PDB entries from 2026-03-04

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