Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6MG8

Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008158	molecular_function	hedgehog receptor activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue CLR A 1401

Chain	Residue
A	SER192
A	ILE206
A	TYR210
A	PRO211
A	TRP242
A	LEU268
A	VAL273
A	SER317
A	GLN924

site_id	AC2
Number of Residues	7
Details	binding site for residue CLR A 1402

Chain	Residue
A	VAL111
A	TRP115
A	LEU413
A	LEU763
A	TYR999
A	PHE1003
A	TRP1004

site_id	AC3
Number of Residues	5
Details	binding site for residue CLR A 1403

Chain	Residue
A	LEU107
A	SER421
A	VAL428
A	PHE481
A	THR486

site_id	AC4
Number of Residues	3
Details	binding site for residue CLR A 1404

Chain	Residue
A	GLY91
A	LEU473
A	PHE569

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=TM1","evidences":[{"source":"PubMed","id":"30415841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33139559","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MG8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K65","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	607
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"30415841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33139559","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34174188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MG8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=TM2","evidences":[{"source":"PubMed","id":"30415841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33139559","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34174188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MG8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	47
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30415841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33139559","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34174188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MG8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=TM3","evidences":[{"source":"PubMed","id":"30415841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33139559","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34174188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MG8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=TM4","evidences":[{"source":"PubMed","id":"30415841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33139559","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34174188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MG8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=TM5","evidences":[{"source":"PubMed","id":"30415841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33139559","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34174188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MG8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=TM6","evidences":[{"source":"PubMed","id":"30415841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33139559","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34174188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MG8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=TM7","evidences":[{"source":"PubMed","id":"30415841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33139559","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34174188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MG8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=TM8","evidences":[{"source":"PubMed","id":"30415841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33139559","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34174188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MG8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=TM9","evidences":[{"source":"PubMed","id":"30415841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33139559","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34174188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MG8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=TM10","evidences":[{"source":"PubMed","id":"30415841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33139559","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34174188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MG8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=TM11","evidences":[{"source":"PubMed","id":"30415841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33139559","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34174188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MG8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=TM12","evidences":[{"source":"PubMed","id":"30415841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33139559","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34174188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MG8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	160
Details	Domain: {"description":"SSD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00199","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34174188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7V6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	21
Details	Region: {"description":"Pre-TM1","evidences":[{"source":"PubMed","id":"30415841","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	319
Details	Region: {"description":"Extracellular domain 1 (ECD1)","evidences":[{"source":"PubMed","id":"30415841","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	15
Details	Region: {"description":"Pre-TM7","evidences":[{"source":"PubMed","id":"30415841","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	257
Details	Region: {"description":"Extracellular domain 2 (ECD2)","evidences":[{"source":"PubMed","id":"30415841","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"33139559","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34174188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7K65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"33139559","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7K65","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"33139559","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34174188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7K65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)