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6MAC

Ternary structure of GDF11 bound to ActRIIB-ECD and Alk5-ECD

Functional Information from GO Data
ChainGOidnamespacecontents
A0005576cellular_componentextracellular region
A0008083molecular_functiongrowth factor activity
C0004675molecular_functiontransmembrane receptor protein serine/threonine kinase activity
C0005524molecular_functionATP binding
C0007178biological_processcell surface receptor protein serine/threonine kinase signaling pathway
C0016020cellular_componentmembrane
K0004675molecular_functiontransmembrane receptor protein serine/threonine kinase activity
K0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00250
Number of Residues16
DetailsTGF_BETA_1 TGF-beta family signature. IiaPkrYkanyCsGqC
ChainResidueDetails
AILE32-CYS47

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

245011

PDB entries from 2025-11-19

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