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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6M04

Structure of the human homo-hexameric LRRC8D channel at 4.36 Angstroms

Functional Information from GO Data
ChainGOidnamespacecontents
A0001678biological_processintracellular glucose homeostasis
A0005225molecular_functionvolume-sensitive anion channel activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0015734biological_processtaurine transmembrane transport
A0015810biological_processaspartate transmembrane transport
A0016020cellular_componentmembrane
A0034214biological_processprotein hexamerization
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0071470biological_processcellular response to osmotic stress
A0098656biological_processmonoatomic anion transmembrane transport
A0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
B0001678biological_processintracellular glucose homeostasis
B0005225molecular_functionvolume-sensitive anion channel activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0015734biological_processtaurine transmembrane transport
B0015810biological_processaspartate transmembrane transport
B0016020cellular_componentmembrane
B0034214biological_processprotein hexamerization
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0071470biological_processcellular response to osmotic stress
B0098656biological_processmonoatomic anion transmembrane transport
B0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
C0001678biological_processintracellular glucose homeostasis
C0005225molecular_functionvolume-sensitive anion channel activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0015734biological_processtaurine transmembrane transport
C0015810biological_processaspartate transmembrane transport
C0016020cellular_componentmembrane
C0034214biological_processprotein hexamerization
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0071470biological_processcellular response to osmotic stress
C0098656biological_processmonoatomic anion transmembrane transport
C0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
D0001678biological_processintracellular glucose homeostasis
D0005225molecular_functionvolume-sensitive anion channel activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0015734biological_processtaurine transmembrane transport
D0015810biological_processaspartate transmembrane transport
D0016020cellular_componentmembrane
D0034214biological_processprotein hexamerization
D0034220biological_processmonoatomic ion transmembrane transport
D0034702cellular_componentmonoatomic ion channel complex
D0071470biological_processcellular response to osmotic stress
D0098656biological_processmonoatomic anion transmembrane transport
D0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
E0001678biological_processintracellular glucose homeostasis
E0005225molecular_functionvolume-sensitive anion channel activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005783cellular_componentendoplasmic reticulum
E0005789cellular_componentendoplasmic reticulum membrane
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0015734biological_processtaurine transmembrane transport
E0015810biological_processaspartate transmembrane transport
E0016020cellular_componentmembrane
E0034214biological_processprotein hexamerization
E0034220biological_processmonoatomic ion transmembrane transport
E0034702cellular_componentmonoatomic ion channel complex
E0071470biological_processcellular response to osmotic stress
E0098656biological_processmonoatomic anion transmembrane transport
E0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
F0001678biological_processintracellular glucose homeostasis
F0005225molecular_functionvolume-sensitive anion channel activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005783cellular_componentendoplasmic reticulum
F0005789cellular_componentendoplasmic reticulum membrane
F0005886cellular_componentplasma membrane
F0006811biological_processmonoatomic ion transport
F0015734biological_processtaurine transmembrane transport
F0015810biological_processaspartate transmembrane transport
F0016020cellular_componentmembrane
F0034214biological_processprotein hexamerization
F0034220biological_processmonoatomic ion transmembrane transport
F0034702cellular_componentmonoatomic ion channel complex
F0071470biological_processcellular response to osmotic stress
F0098656biological_processmonoatomic anion transmembrane transport
F0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues150
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"32415200","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6M04","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues108
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"32415200","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6M04","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues114
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"32415200","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6M04","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues186
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"32415200","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6M04","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues150
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"32415200","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6M04","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues120
DetailsRepeat: {"description":"LRR 1"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues126
DetailsRepeat: {"description":"LRR 2"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues126
DetailsRepeat: {"description":"LRR 3"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues120
DetailsRepeat: {"description":"LRR 4"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues120
DetailsRepeat: {"description":"LRR 5"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues126
DetailsRepeat: {"description":"LRR 6"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues126
DetailsRepeat: {"description":"LRR 7"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues126
DetailsRepeat: {"description":"LRR 8"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues126
DetailsRepeat: {"description":"LRR 9"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues126
DetailsRepeat: {"description":"LRR 10"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues126
DetailsRepeat: {"description":"LRR 11"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues126
DetailsRepeat: {"description":"LRR 12"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues126
DetailsRepeat: {"description":"LRR 13"}
ChainResidueDetails

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PDB entries from 2025-08-27

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