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6LKQ

The Structural Basis for Inhibition of Ribosomal Translocation by Viomycin

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
00003735molecular_functionstructural constituent of ribosome
00005840cellular_componentribosome
00006412biological_processtranslation
10003735molecular_functionstructural constituent of ribosome
10005840cellular_componentribosome
10006412biological_processtranslation
10015934cellular_componentlarge ribosomal subunit
20003735molecular_functionstructural constituent of ribosome
20005840cellular_componentribosome
20006412biological_processtranslation
20015934cellular_componentlarge ribosomal subunit
20019843molecular_functionrRNA binding
20022625cellular_componentcytosolic large ribosomal subunit
21990904cellular_componentribonucleoprotein complex
30003735molecular_functionstructural constituent of ribosome
30005840cellular_componentribosome
30006412biological_processtranslation
30019843molecular_functionrRNA binding
40003735molecular_functionstructural constituent of ribosome
40005840cellular_componentribosome
40006412biological_processtranslation
50003735molecular_functionstructural constituent of ribosome
50005840cellular_componentribosome
50006412biological_processtranslation
60003735molecular_functionstructural constituent of ribosome
60005840cellular_componentribosome
60006412biological_processtranslation
80003735molecular_functionstructural constituent of ribosome
80005840cellular_componentribosome
80006412biological_processtranslation
80019843molecular_functionrRNA binding
90003723molecular_functionRNA binding
90003735molecular_functionstructural constituent of ribosome
90005840cellular_componentribosome
90006412biological_processtranslation
A0003735molecular_functionstructural constituent of ribosome
A0005840cellular_componentribosome
A0006412biological_processtranslation
A0015935cellular_componentsmall ribosomal subunit
A0022627cellular_componentcytosolic small ribosomal subunit
A1990904cellular_componentribonucleoprotein complex
B0003676molecular_functionnucleic acid binding
B0003723molecular_functionRNA binding
B0003735molecular_functionstructural constituent of ribosome
B0006412biological_processtranslation
C0003723molecular_functionRNA binding
C0003735molecular_functionstructural constituent of ribosome
C0005840cellular_componentribosome
C0006412biological_processtranslation
C0015935cellular_componentsmall ribosomal subunit
C0019843molecular_functionrRNA binding
C0042274biological_processribosomal small subunit biogenesis
C1990904cellular_componentribonucleoprotein complex
D0003723molecular_functionRNA binding
D0003735molecular_functionstructural constituent of ribosome
D0005840cellular_componentribosome
D0006412biological_processtranslation
D0015935cellular_componentsmall ribosomal subunit
E0003735molecular_functionstructural constituent of ribosome
E0005840cellular_componentribosome
E0006412biological_processtranslation
E0019843molecular_functionrRNA binding
F0003723molecular_functionRNA binding
F0003735molecular_functionstructural constituent of ribosome
F0006412biological_processtranslation
F0015935cellular_componentsmall ribosomal subunit
G0003735molecular_functionstructural constituent of ribosome
G0005840cellular_componentribosome
G0006412biological_processtranslation
H0003735molecular_functionstructural constituent of ribosome
H0005840cellular_componentribosome
H0006412biological_processtranslation
I0003723molecular_functionRNA binding
I0003735molecular_functionstructural constituent of ribosome
I0005840cellular_componentribosome
I0006412biological_processtranslation
J0003735molecular_functionstructural constituent of ribosome
J0005840cellular_componentribosome
J0006412biological_processtranslation
K0003735molecular_functionstructural constituent of ribosome
K0005840cellular_componentribosome
K0006412biological_processtranslation
K0015935cellular_componentsmall ribosomal subunit
L0003676molecular_functionnucleic acid binding
L0003723molecular_functionRNA binding
L0003735molecular_functionstructural constituent of ribosome
L0005840cellular_componentribosome
L0006412biological_processtranslation
M0003735molecular_functionstructural constituent of ribosome
M0005737cellular_componentcytoplasm
M0005840cellular_componentribosome
M0006412biological_processtranslation
M0015935cellular_componentsmall ribosomal subunit
M0019843molecular_functionrRNA binding
M1990904cellular_componentribonucleoprotein complex
N0003735molecular_functionstructural constituent of ribosome
N0005840cellular_componentribosome
N0006412biological_processtranslation
O0003735molecular_functionstructural constituent of ribosome
O0005840cellular_componentribosome
O0006412biological_processtranslation
P0003735molecular_functionstructural constituent of ribosome
P0005840cellular_componentribosome
P0006412biological_processtranslation
Q0003735molecular_functionstructural constituent of ribosome
Q0005840cellular_componentribosome
Q0006412biological_processtranslation
R0003723molecular_functionRNA binding
R0003735molecular_functionstructural constituent of ribosome
R0005840cellular_componentribosome
R0006412biological_processtranslation
R0015935cellular_componentsmall ribosomal subunit
S0003723molecular_functionRNA binding
S0003735molecular_functionstructural constituent of ribosome
S0005840cellular_componentribosome
S0006412biological_processtranslation
T0003735molecular_functionstructural constituent of ribosome
T0005840cellular_componentribosome
T0006412biological_processtranslation
U0003723molecular_functionRNA binding
U0003735molecular_functionstructural constituent of ribosome
U0005840cellular_componentribosome
U0006412biological_processtranslation
U0015934cellular_componentlarge ribosomal subunit
U0016740molecular_functiontransferase activity
V0003735molecular_functionstructural constituent of ribosome
V0005840cellular_componentribosome
V0006412biological_processtranslation
W0003735molecular_functionstructural constituent of ribosome
W0005840cellular_componentribosome
W0006412biological_processtranslation
X0003735molecular_functionstructural constituent of ribosome
X0005840cellular_componentribosome
X0006412biological_processtranslation
Y0003735molecular_functionstructural constituent of ribosome
Y0005840cellular_componentribosome
Y0006412biological_processtranslation
Y0019843molecular_functionrRNA binding
Z0003735molecular_functionstructural constituent of ribosome
Z0005840cellular_componentribosome
Z0006412biological_processtranslation
a0003735molecular_functionstructural constituent of ribosome
a0005840cellular_componentribosome
a0006412biological_processtranslation
a0015934cellular_componentlarge ribosomal subunit
b0003735molecular_functionstructural constituent of ribosome
b0005840cellular_componentribosome
b0006412biological_processtranslation
c0003723molecular_functionRNA binding
c0003735molecular_functionstructural constituent of ribosome
c0005840cellular_componentribosome
c0006412biological_processtranslation
d0003735molecular_functionstructural constituent of ribosome
d0005840cellular_componentribosome
d0006412biological_processtranslation
d0008097molecular_function5S rRNA binding
e0003735molecular_functionstructural constituent of ribosome
e0005840cellular_componentribosome
e0006412biological_processtranslation
f0003735molecular_functionstructural constituent of ribosome
f0005840cellular_componentribosome
f0006412biological_processtranslation
g0003735molecular_functionstructural constituent of ribosome
g0005840cellular_componentribosome
g0006412biological_processtranslation
h0003735molecular_functionstructural constituent of ribosome
h0006412biological_processtranslation
h0015934cellular_componentlarge ribosomal subunit
i0003735molecular_functionstructural constituent of ribosome
i0006412biological_processtranslation
i0015934cellular_componentlarge ribosomal subunit
j0003735molecular_functionstructural constituent of ribosome
j0005840cellular_componentribosome
j0006412biological_processtranslation
k0003735molecular_functionstructural constituent of ribosome
k0005840cellular_componentribosome
k0006412biological_processtranslation
l0003735molecular_functionstructural constituent of ribosome
l0005840cellular_componentribosome
l0006412biological_processtranslation
m0003735molecular_functionstructural constituent of ribosome
m0005840cellular_componentribosome
m0006412biological_processtranslation
n0003735molecular_functionstructural constituent of ribosome
n0006412biological_processtranslation
n0015934cellular_componentlarge ribosomal subunit
o0003735molecular_functionstructural constituent of ribosome
o0005840cellular_componentribosome
o0006412biological_processtranslation
p0003735molecular_functionstructural constituent of ribosome
p0005840cellular_componentribosome
p0006412biological_processtranslation
q0003735molecular_functionstructural constituent of ribosome
q0005840cellular_componentribosome
q0006412biological_processtranslation
r0003735molecular_functionstructural constituent of ribosome
r0005840cellular_componentribosome
r0006412biological_processtranslation
v0003924molecular_functionGTPase activity
v0005525molecular_functionGTP binding
v0005737cellular_componentcytoplasm
v0005829cellular_componentcytosol
v0006412biological_processtranslation
v0006415biological_processtranslational termination
v0006449biological_processregulation of translational termination
v0016149molecular_functiontranslation release factor activity, codon specific
v0016150molecular_functiontranslation release factor activity, codon nonspecific
v0097216molecular_functionguanosine tetraphosphate binding
Functional Information from PDB Data
site_idAC1
Number of Residues13
Detailsbinding site for Ligand residues UAL AA 5 through SER AA 3 bound to SER AA 4
ChainResidue
7KBE1
tC1934
tA1960
tC1961
tC1962
AASER4
BA5OH6
sG1416
sC1484
sU1485
sG1486
tA1932
tG1933

site_idAC2
Number of Residues8
Detailsbinding site for Ligand residues UAL BA 5 through SER BA 3 bound to SER BA 4
ChainResidue
7KBE1
AA5OH6
BASER4
tU1917
tA1918
tG1930
tC1962
tU1963

site_idAC3
Number of Residues9
Detailsbinding site for Viomycin chain y
ChainResidue
KTHR40
sA1408
sG1491
sA1492
sA1493
sG1494
sU1495
sC1496
tC1914

site_idAC4
Number of Residues13
Detailsbinding site for Viomycin chain z
ChainResidue
KLYS42
KLYS43
sU13
sU14
sA16
sC526
sG527
sC912
sA913
sA914
sA915
sU1490
sG1491

site_idAC5
Number of Residues13
Detailsbinding site for Viomycin chain 7
ChainResidue
AASER4
AAUAL5
BAKBE1
BADPP2
sU793
sG1517
tA1919
tC1920
tU1931
tA1932
tG1933
tC1967
tG1968

site_idAC6
Number of Residues14
Detailsbinding site for Viomycin chain BA
ChainResidue
BASN7
BGLY8
BILE9
BARG10
BLEU174
BTYR183
MMET88
sU1060
sG1061
sU1189
sG1190
sA1191
sC1192
sG1193

Functional Information from PROSITE/UniProt
site_idPS00049
Number of Residues27
DetailsRIBOSOMAL_L14 Ribosomal protein L14 signature. AVVVrtkkgvrrp.DGsvirFdgNacVL
ChainResidueDetails
1ALA60-LEU86

site_idPS00052
Number of Residues27
DetailsRIBOSOMAL_S7 Ribosomal protein S7 signature. SeLlakFVnilmvdGKKstaesIVysA
ChainResidueDetails
FSER19-ALA45

site_idPS00053
Number of Residues18
DetailsRIBOSOMAL_S8 Ribosomal protein S8 signature. GiaVVSTSkGVMtdraAR
ChainResidueDetails
GGLY99-ARG116

site_idPS00054
Number of Residues23
DetailsRIBOSOMAL_S11 Ribosomal protein S11 signature. IrALnaA.GFrItnitDvTPiPHN
ChainResidueDetails
JILE96-ASN118

site_idPS00055
Number of Residues8
DetailsRIBOSOMAL_S12 Ribosomal protein S12 signature. KkPNSAlR
ChainResidueDetails
KLYS42-ARG49

site_idPS00056
Number of Residues13
DetailsRIBOSOMAL_S17 Ribosomal protein S17 signature. GDvVeIrEcRPLS
ChainResidueDetails
PGLY55-SER67

site_idPS00057
Number of Residues24
DetailsRIBOSOMAL_S18 Ribosomal protein S18 signature. IDYkd.IatLknYITEs.GKIvpsRI
ChainResidueDetails
QILE20-ILE43

site_idPS00061
Number of Residues29
DetailsADH_SHORT Short-chain dehydrogenases/reductases family signature. PdhkhavialTsiYGVGKTRSkAILaAAG
ChainResidueDetails
LPRO9-GLY37

site_idPS00301
Number of Residues16
DetailsG_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DWmemEKqRGISIttS
ChainResidueDetails
vASP58-SER73

site_idPS00323
Number of Residues25
DetailsRIBOSOMAL_S19 Ribosomal protein S19 signature. NGRqhvpvfVtdemVGhkLGEFapT
ChainResidueDetails
RASN52-THR76

site_idPS00358
Number of Residues17
DetailsRIBOSOMAL_L5 Ribosomal protein L5 signature. LaaISGQkpLiTkARkS
ChainResidueDetails
XLEU56-SER72

site_idPS00359
Number of Residues16
DetailsRIBOSOMAL_L11 Ribosomal protein L11 signature. RsIeGTarSMGlVVeD
ChainResidueDetails
ZARG126-ASP141

site_idPS00360
Number of Residues19
DetailsRIBOSOMAL_S9 Ribosomal protein S9 signature. GGGisGQagAirhGiTRAL
ChainResidueDetails
HGLY68-LEU86

site_idPS00361
Number of Residues16
DetailsRIBOSOMAL_S10 Ribosomal protein S10 signature. AkrtGAqvrGPIpLPT
ChainResidueDetails
IALA29-THR44

site_idPS00362
Number of Residues31
DetailsRIBOSOMAL_S15 Ribosomal protein S15 signature. LqgHFaehKkDhhSrrgLlrMvsqrrkLldY
ChainResidueDetails
NLEU38-TYR68

site_idPS00430
Number of Residues66
DetailsTONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. mireerllkvlraphvsekastameksntivlkvakdatkaeikaavqklfevevevv.........................................................NTLVVKGK
ChainResidueDetails
bMET1-LYS66

site_idPS00464
Number of Residues25
DetailsRIBOSOMAL_L22 Ribosomal protein L22 signature. KriMpRAkGRadrilkrtSHITVvV
ChainResidueDetails
aLYS83-VAL107

site_idPS00467
Number of Residues12
DetailsRIBOSOMAL_L2 Ribosomal protein L2 signature. PtvRGTAmNPvD
ChainResidueDetails
UPRO217-ASP228

site_idPS00474
Number of Residues24
DetailsRIBOSOMAL_L3 Ribosomal protein L3 signature. FadvkkvDvtGtSkGKGfaGtvkR
ChainResidueDetails
VPHE101-ARG124

site_idPS00475
Number of Residues31
DetailsRIBOSOMAL_L15 Ribosomal protein L15 signature. KVILaGeVttp..VtVrglrVTkgAraaIeaaG
ChainResidueDetails
2LYS109-GLY139

site_idPS00525
Number of Residues9
DetailsRIBOSOMAL_L6_1 Ribosomal protein L6 signature 1. PEpYKGKGV
ChainResidueDetails
YPRO153-VAL161

site_idPS00527
Number of Residues23
DetailsRIBOSOMAL_S14 Ribosomal protein S14 signature. R.CrqtgrphgflrkFGLSRiKVR
ChainResidueDetails
MARG62-ARG84

site_idPS00548
Number of Residues35
DetailsRIBOSOMAL_S3 Ribosomal protein S3 signature. ARtewyreGrVplHt..LradIDyntseahTtyGviG
ChainResidueDetails
BALA162-GLY196

site_idPS00579
Number of Residues15
DetailsRIBOSOMAL_L29 Ribosomal protein L29 signature. QSHLLKqVRRDVARV
ChainResidueDetails
gGLN39-VAL53

site_idPS00582
Number of Residues20
DetailsRIBOSOMAL_L33 Ribosomal protein L33 signature. YtTtKNkrtkPekLElkKFD
ChainResidueDetails
jTYR20-ASP39

site_idPS00585
Number of Residues33
DetailsRIBOSOMAL_S5 Ribosomal protein S5 signature. GRifsFtAltVVGDgn.GrVGfGygkar.EVpa.AI
ChainResidueDetails
DGLY27-ILE59

site_idPS00586
Number of Residues12
DetailsRIBOSOMAL_L16_1 Ribosomal protein L16 signature 1. KRqGKIWIRVFP
ChainResidueDetails
3LYS58-PRO69

site_idPS00632
Number of Residues25
DetailsRIBOSOMAL_S4 Ribosomal protein S4 signature. LEgRLdnvVYRmgfGaTraeARqLV
ChainResidueDetails
CLEU93-VAL117

site_idPS00634
Number of Residues33
DetailsRIBOSOMAL_L30 Ribosomal protein L30 signature. TLlgLgLrRigHtVeredtpairgMInaVsfMV
ChainResidueDetails
hTHR22-VAL54

site_idPS00646
Number of Residues14
DetailsRIBOSOMAL_S13_1 Ribosomal protein S13 signature. RGlRHrrGlpVRGQ
ChainResidueDetails
LARG86-GLN99

site_idPS00701
Number of Residues12
DetailsRIBOSOMAL_L16_2 Ribosomal protein L16 signature 2. RMGkGKGnveyW
ChainResidueDetails
3ARG81-TRP92

site_idPS00732
Number of Residues10
DetailsRIBOSOMAL_S16 Ribosomal protein S16 signature. VtIRLARHGA
ChainResidueDetails
OVAL2-ALA11

site_idPS00783
Number of Residues23
DetailsRIBOSOMAL_L13 Ribosomal protein L13 signature. VKGMLPkgpl.GRamfrkLkVYaG
ChainResidueDetails
0VAL105-GLY127

site_idPS00784
Number of Residues20
DetailsRIBOSOMAL_L34 Ribosomal protein L34 signature. KRTFQpsvlkRnrsh.GFraR
ChainResidueDetails
kLYS2-ARG21

site_idPS00828
Number of Residues27
DetailsRIBOSOMAL_L36 Ribosomal protein L36 signature. CrnCkiVkRdgvIrViCsaepKHkQrQ
ChainResidueDetails
mCYS11-GLN37

site_idPS00831
Number of Residues15
DetailsRIBOSOMAL_L27 Ribosomal protein L27 signature. GsIIvRQRGtkfhaG
ChainResidueDetails
eGLY33-GLY47

site_idPS00936
Number of Residues27
DetailsRIBOSOMAL_L35 Ribosomal protein L35 signature. KTVrGAaKRFkktgkggfkhkhanl.RH
ChainResidueDetails
lLYS4-HIS30

site_idPS00937
Number of Residues17
DetailsRIBOSOMAL_L20 Ribosomal protein L20 signature. KrqfRqLWIARINaaaR
ChainResidueDetails
8LYS53-ARG69

site_idPS00963
Number of Residues25
DetailsRIBOSOMAL_S2_2 Ribosomal protein S2 signature 2. PdaLFViDadhEhiaIkEannlGIP
ChainResidueDetails
APRO157-PRO181

site_idPS01015
Number of Residues16
DetailsRIBOSOMAL_L19 Ribosomal protein L19 signature. VkRrGAVR.KAKLYYLR
ChainResidueDetails
6VAL85-ARG100

site_idPS01048
Number of Residues10
DetailsRIBOSOMAL_S6 Ribosomal protein S6 signature. GrRQLAYpIN
ChainResidueDetails
EGLY43-ASN52

site_idPS01108
Number of Residues18
DetailsRIBOSOMAL_L24 Ribosomal protein L24 signature. DDeViVLtGkdKGkr.GkV
ChainResidueDetails
cASP7-VAL24

site_idPS01109
Number of Residues35
DetailsRIBOSOMAL_L10 Ribosomal protein L10 signature. KqaIvaeVSevakgalsaVvaDsrGVTVdKMteLR
ChainResidueDetails
nLYS8-ARG42

site_idPS01167
Number of Residues23
DetailsRIBOSOMAL_L17 Ribosomal protein L17 signature. IkTTlpKaKelrrvvEpLITlAK
ChainResidueDetails
4ILE34-LYS56

site_idPS01169
Number of Residues23
DetailsRIBOSOMAL_L21 Ribosomal protein L21 signature. VkivKfrrRKhyrkqqGHRQwfT
ChainResidueDetails
9VAL72-THR94

site_idPS01181
Number of Residues13
DetailsRIBOSOMAL_S21 Ribosomal protein S21 signature. DvALRRFKRsceK
ChainResidueDetails
TASP12-LYS24

227111

PDB entries from 2024-11-06

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