6LKD
in meso full-length rat KMO in complex with a pyrazoyl benzoic acid inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004502 | molecular_function | kynurenine 3-monooxygenase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0006569 | biological_process | L-tryptophan catabolic process |
| A | 0009435 | biological_process | NAD+ biosynthetic process |
| A | 0014049 | biological_process | positive regulation of glutamate secretion |
| A | 0016174 | molecular_function | NAD(P)H oxidase H2O2-forming activity |
| A | 0019674 | biological_process | NAD+ metabolic process |
| A | 0019805 | biological_process | quinolinate biosynthetic process |
| A | 0031966 | cellular_component | mitochondrial membrane |
| A | 0032496 | biological_process | response to lipopolysaccharide |
| A | 0034276 | biological_process | kynurenic acid biosynthetic process |
| A | 0034354 | biological_process | 'de novo' NAD+ biosynthetic process from L-tryptophan |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0071222 | biological_process | cellular response to lipopolysaccharide |
| A | 0071347 | biological_process | cellular response to interleukin-1 |
| A | 0071949 | molecular_function | FAD binding |
| A | 1903296 | biological_process | positive regulation of glutamate secretion, neurotransmission |
| B | 0004502 | molecular_function | kynurenine 3-monooxygenase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005741 | cellular_component | mitochondrial outer membrane |
| B | 0006569 | biological_process | L-tryptophan catabolic process |
| B | 0009435 | biological_process | NAD+ biosynthetic process |
| B | 0014049 | biological_process | positive regulation of glutamate secretion |
| B | 0016174 | molecular_function | NAD(P)H oxidase H2O2-forming activity |
| B | 0019674 | biological_process | NAD+ metabolic process |
| B | 0019805 | biological_process | quinolinate biosynthetic process |
| B | 0031966 | cellular_component | mitochondrial membrane |
| B | 0032496 | biological_process | response to lipopolysaccharide |
| B | 0034276 | biological_process | kynurenic acid biosynthetic process |
| B | 0034354 | biological_process | 'de novo' NAD+ biosynthetic process from L-tryptophan |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0071222 | biological_process | cellular response to lipopolysaccharide |
| B | 0071347 | biological_process | cellular response to interleukin-1 |
| B | 0071949 | molecular_function | FAD binding |
| B | 1903296 | biological_process | positive regulation of glutamate secretion, neurotransmission |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | binding site for residue FAD A 1001 |
| Chain | Residue |
| A | ILE14 |
| A | SER53 |
| A | LEU56 |
| A | ALA57 |
| A | ARG111 |
| A | HIS134 |
| A | LEU136 |
| A | CYS166 |
| A | ASP167 |
| A | THR172 |
| A | TYR194 |
| A | GLY15 |
| A | ASP304 |
| A | PRO311 |
| A | GLY314 |
| A | GLY316 |
| A | MET317 |
| A | ASN318 |
| A | EGO1002 |
| A | CL1004 |
| A | GLY17 |
| A | LEU18 |
| A | VAL19 |
| A | TYR37 |
| A | GLU38 |
| A | ALA39 |
| A | ARG40 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue EGO A 1002 |
| Chain | Residue |
| A | ARG85 |
| A | TYR99 |
| A | LEU213 |
| A | ILE215 |
| A | ILE224 |
| A | PHE238 |
| A | PRO311 |
| A | PHE312 |
| A | ASN363 |
| A | MET367 |
| A | VAL371 |
| A | PHE376 |
| A | GLN379 |
| A | ARG380 |
| A | TYR398 |
| A | FAD1001 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 1003 |
| Chain | Residue |
| A | ARG85 |
| A | PRO98 |
| A | TYR99 |
| A | GLY100 |
| A | LYS384 |
| A | PRO396 |
| A | TYR398 |
| A | THR399 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 1004 |
| Chain | Residue |
| A | PRO311 |
| A | GLY316 |
| A | FAD1001 |
| site_id | AC5 |
| Number of Residues | 28 |
| Details | binding site for residue FAD B 1001 |
| Chain | Residue |
| B | GLY15 |
| B | GLY17 |
| B | LEU18 |
| B | VAL19 |
| B | TYR37 |
| B | GLU38 |
| B | ALA39 |
| B | ARG40 |
| B | SER53 |
| B | LEU56 |
| B | ALA57 |
| B | ARG111 |
| B | HIS134 |
| B | LYS135 |
| B | LEU136 |
| B | CYS166 |
| B | ASP167 |
| B | GLY168 |
| B | THR172 |
| B | ASP304 |
| B | PRO311 |
| B | GLY314 |
| B | GLN315 |
| B | GLY316 |
| B | MET317 |
| B | ASN318 |
| B | EGO1002 |
| B | CL1004 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for residue EGO B 1002 |
| Chain | Residue |
| B | ARG85 |
| B | TYR99 |
| B | LEU213 |
| B | ILE215 |
| B | ILE224 |
| B | PHE238 |
| B | PRO311 |
| B | PHE312 |
| B | ASN363 |
| B | PHE376 |
| B | ARG380 |
| B | TYR398 |
| B | FAD1001 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 1003 |
| Chain | Residue |
| B | LYS384 |
| B | PRO396 |
| B | TYR398 |
| B | THR399 |
| B | ARG85 |
| B | TYR99 |
| B | GLY100 |
| B | ARG380 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 1004 |
| Chain | Residue |
| B | PRO311 |
| B | GLY316 |
| B | FAD1001 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 38 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"HAMAP-Rule","id":"MF_03018","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"O15229","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q84HF5","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
