6LK5
MLKL mutant - T357ES358D
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0012501 | biological_process | programmed cell death |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0030054 | cellular_component | cell junction |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0051607 | biological_process | defense response to virus |
| A | 0070207 | biological_process | protein homotrimerization |
| A | 0070266 | biological_process | necroptotic process |
| A | 0097527 | biological_process | necroptotic signaling pathway |
| A | 0097528 | biological_process | execution phase of necroptosis |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | LEU209 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | LYS230 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Target of necrosulfonamide inhibitor => ECO:0000269|PubMed:22265413 |
| Chain | Residue | Details |
| A | CYS86 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976 |
| Chain | Residue | Details |
| A | SER125 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by RIPK3 => ECO:0000269|PubMed:22265413 |
| Chain | Residue | Details |
| A | GLU357 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by RIPK3 => ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:29883610 |
| Chain | Residue | Details |
| A | ASP358 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by RIPK3 => ECO:0000250|UniProtKB:Q9D2Y4 |
| Chain | Residue | Details |
| A | SER360 |
