6LB4
Crystal structure of dimeric RXR-LBD complexed with NEt-3ME and TIF2 co-activator
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue E8L A 501 |
| Chain | Residue |
| A | ILE268 |
| A | ALA327 |
| A | PHE346 |
| A | CYS432 |
| A | HOH620 |
| A | ALA271 |
| A | ALA272 |
| A | GLN275 |
| A | LEU309 |
| A | ILE310 |
| A | PHE313 |
| A | ARG316 |
| A | LEU326 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | ARG334 |
| A | PHE346 |
| A | ASP347 |
| A | THR351 |
| A | HOH623 |
| A | HOH767 |
| A | HOH787 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | VAL320 |
| A | LYS321 |
| A | ASP322 |
| A | GLY323 |
| A | HIS331 |
| A | HOH642 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | PRO378 |
| A | GLU390 |
| A | ARG393 |
| A | GLU394 |
| A | TYR397 |
| A | LYS417 |
| A | HOH607 |
| A | HOH646 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | ARG348 |
| A | ARG426 |
| A | SER427 |
| A | LEU430 |
| A | HOH666 |
| A | HOH700 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Region: {"description":"Required for nuclear export","evidences":[{"source":"PubMed","id":"15509776","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16107141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18800767","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19167885","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ACL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FC6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Motif: {"description":"LXXLL motif 2"} |
| Chain | Residue | Details |
